MARIA CANDIDA PINHEIRO BARACAT REZENDE
Projetos de Pesquisa
Unidades Organizacionais
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
9 resultados
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Agora exibindo 1 - 9 de 9
bookPart Análogos do hormônio liberador de gonadotrofina(2014) JúNIOR, José Maria Soares; AMARAL, Vínicius Cestari do; BARACAT, Maria Cândida Pinheiro; SIMõES, Ricardo dos Santos; BARACAT, Edmund ChadabookPart Biologia molecular do leiomioma uterino - aspectos moleculares(2014) BOZZINI, Nilo; BORSARI, Rodrigo; JúNIOR, José Maria Soares; BARACAT, Maria Cândida Pinheiro; BARACAT, Edmund ChadabookPart Aspectos moleculares da síndrome dos ovários policísticos(2014) MACIEL, Gustavo Arantes Rosa; BARACAT, Maria Cândida Pinheiro; MARCONDES, Rodrigo Rodrigues; JúNIOR, José Maria Soares; BARACAT, Edmund ChadabookPart Hormônio liberador de gonadotrofina(2014) CARVALHO, Kátia Candido; AMARAL, Vinícius Cestari do; BARACAT, Maria Cândida Pinheiro; JúNIOR, José Maria Soares; BARACAT, Edmund ChadabookPart Carcinogênese mamária induzida em animais(2014) JúNIOR, José Maria Soares; SIMõES, Ricardo dos Santos; BARACAT, Maria Cândida Pinheiro; FILASSI, José Roberto; BARACAT, Edmund ChadabookPart Bases moleculares de ação do estrogênio(2014) JúNIOR, José Maria Soares; SALOMãO, Antônio Jorge; CARBONEL, Adriana Aparecida Ferraz; BARACAT, Maria Cândida Pinheiro; BARACAT, Edmund ChadabookPart Estro permanente - modelo experimental(2014) JúNIOR, José Maria Soares; BARACAT, Maria Cândida Pinheiro; SIMõES, Manuel de Jesus; SIMõES, Ricardo dos Santos; BARACAT, Edmund Chada- Immunohistochemical evaluation of proliferation, apoptosis and steroidogenic enzymes in the ovary of rats with polycystic ovary(2014) LOMBARDI, Leonardo Augusto; SIMOES, Ricardo Santos; MAGANHIN, Carla Cristina; BARACAT, Maria Candida Pinheiro; SILVA-SASSO, Gisela Rodrigues; FLORENCIO-SILVA, Rinaldo; SOARES JR., Jose Maria; BARACAT, Edmund ChadaObjective: to evaluate the immunohistochemical expression of proliferative, apoptotic and steroidogenic enzyme markers in the ovaries of rats with polycystic ovary syndrome (PCOS). Methods: twenty rats were divided into two groups: GCtrl - estrous phase, and PCOS - with polycystic ovaries. The GCtrl animals were subjected to a lighting period from 7 am to 7 pm, while the animals with PCOS group remained with continuous lighting for 60 days. Subsequently, the animals were anesthetized, the ovaries were removed and fixed in 10% formaldehyde, prior to paraffin embedding. Sections were stained using H.E. or subjected to immunohistochemical methods for the detection of Ki-67, cleaved caspase-3, CYP11A1, CYP17A1 and CYP19A1. The results were analyzed using Student's t-test (p < 0,05). Results: morphological results showed evidence of interstitial cells originating from the inner theca cells of degenerating ovarian cysts in PCOS. Immunoexpression of Ki-67 was higher in the granulosa cells in GCtrl, and the theca interna cells in PCOS, while cleaved caspase-3 was higher in granulosa cells of ovarian cysts from PCOS and in the theca interna cells of GCtrl. Immunoreactivity of CYP11A1 in the theca interna, granulosa and interstitial cells was similar between the two groups, while CYP17A1 and CYP19A1 were higher in the granulosa and interstitial cells in the PCOS group. Conclusion: the results indicate that the interstitial cells are derived from the theca interna and that enzymatic changes occur in the theca interna and interstitial cells in ovaries of rats with PCOS, responsible for the high levels of androgens and estradiol.
bookPart Pólipo endometrial(2014) PINHEIRO, Walter da Silva; JúNIOR, José Maria Soares; BARACAT, Maria Cândida Pinheiro; BARACAT, Edmund Chada