MARILENE ALICIA SOUZA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
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- The expression of the estrogen receptor in obese patients with high breast density (HBD)(2014) SOUZA, Marilene Alicia; FONSECA, Angela de Maggio da; BAGNOLI, Vicente Renato; BARROS, Nestor de; NEVES, Erica Mendonca das; MORAES, Sandra Dircinha Teixeira de Araujo; HORTENSE, Victor Hugo Souza; SOARES, Jose Maria; BARACAT, Edmund ChadaObjective: Obesity has been associated with increased risk for breast cancer (BC) mortality. Verifying in women with high breast density (HBD) post-menopausal, the frequency of polymorphisnns of estrogen receptor (ER)alpha-Pvull, ER alpha-Xbal and if they influence the body mass index (BMI). Methods: Study with 308 women with HBD post-menopause divided into two groups according to BMI: 1st group = BMI <25 kg/m(2), 2nd group = BMI >= 25 kg/m(2). It was characterized in the clinical history: menarche, menopause, parity, family history of BC, smoking and alcohol intake. Results: Allele and genotype frequencies for the ER alpha-397-Pvull and ER alpha-351-Xbal: P =43.99%, p =56.01%, pp =32.14%, Pp =47.73%, PP =X =20.13% and X=41.56%, x=58.44%; xx = 33.44%; Xx =50.00%; XX =16.56%, respectively. Both Pvull and Xbal influenced BMI. When Xbal is mutated the tendency is toward higher BMI (0.039), and women with lower BMI were more frequent in Pvull genotype (p = 0.002). More frequent risk factors for BC: menarche before the age of 12 years (35.38%), nulliparity or 1st child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%). Conclusion: Variations in the ER alpha gene affected the BMI in women with HBD, who already are at increased risk for BC.
- Polymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopause(2013) SOUZA, Marilene Alicia; FONSECA, Angela Maggio; BAGNOLI, Vicente R.; BARROS, Nestor de; FRANZOLIN, Solange O. B.; CARVALHO, Katia C.; SOARES- JR., Jose Maria; BARACAT, Edmund C.The association of genetic polymorphism in the estrogen receptor alpha (ER alpha) gene and risk for diseases including breast cancer (BC) has been the subject of great interest. Objective: Checking on women with high breast density after menopause, the frequency of the Pvull and Xbal polymorphisms of the ER alpha gene and the correlation between them and the known risk factors for breast cancer. Method: Observational study with 308 women between 45 and 65 years old with high breast density, without hormonal therapy, menstruation for a year or more, breast and ovarian cancer history. It was characterized in clinical history and physical examination: menarche, menopause, parity, family history of BC, smoking, alcohol intake and body mass index. Results: The allelic and genotypic frequencies for ER alpha-Pvull and Xbal: p = 43.99%; p = 56.01%; pp = 32.14%; Pp = 47.73% and PP = 20.13%; X = 41.56%; x = 58.44%; xx = 33.44%; Xx = 50.00% and XX = 16.56%, respectively. The most frequent risk factors for BC: menarche before 12 years old (35.38%), nulliparity or first child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%). Conclusion: Allelic and genotypic distribution similar to literature. The risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms.