LEANDRO RYUCHI IUAMOTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado, Hospital das Clínicas, Faculdade de Medicina
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Study of Burkholderia Cepacia Complex Strains in Lung Transplant Patients: Analysis of Genomovar and Mortality Impact(2014) CARRARO, D. S.; CAMPOS, S. V.; OLIVEIRA-BRAGA, K. A.; IUAMOTO, L. R.; CARRARO, R. M.; OLIVEIRA, L. C.; ROSSI, F.; SABINO, E. C.; PEGO-FERNANDES, P. M.
- Parameters involved and viability of immunosuppression on islet allotransplantation procedure in rodents(2014) IUAMOTO, Leandro R.; MEYER, Alberto; CHAIB, Eleazar; D'ALBUQUERQUE, Luiz ACINTRODUCTION: Autoimmunity and rejection after transplantation must still be overcome in the technical development of islet transplantation for the treatment of type 1 diabetes. It is therefore necessary to inhibit rejection of islet grafts while maintaining the graft's ability to secrete insulin. Although the use of immunosuppressants reduces the acute rejection rate in transplant patients, long-term side effects must be prevented. OBJECTIVES: The aim of the present study is to organize and analyze the parameters of immunosuppression involved in experimental attempts of allotransplantation in rodents. METHODOLOGY: This review was performed using the Pubmed database to search for published articles containing the keywords ""rodent islet transplantation"". The inclusion criteria involved allotransplantation with rodents' islets and the reference lists of the publications retrieved that were eligible. The exclusion criteria involved isotransplantation, autotransplantation, and xenotransplantation such as transplantation in other species. RESULTS: Twenty studies related to allotransplantation were selected for this systematic review based on immunosuppression. CONCLUSION: New immunosuppressive drugs increased the survival rates of allotransplantation in rodents by reducing the side effects. The advances in immunosuppression raise the possibility of overcoming autoimmunity and rejection after allotransplantation.
bookPart Breve história da cirurgia cardiovascular no Brasil e no mundo(2014) LIGUORI, Gabriel Romero; KANAS, Alexandre Fligelman; IUAMOTO, Leandro Ryuchi; MARQUES, Laís Costa; VELOSO, Patrícia Maquinêz; JATENE, Marcelo Biscegli- Review of experimental attempts of islet allotransplantation in rodents: Parameters involved and viability of the procedure(2014) IUAMOTO, Leandro Ryuchi; MEYER, Alberto; CHAIB, Eleazar; D'ALBUQUERQUE, Luiz Augusto CarneiroThe purpose of the present study was to organize the parameters involved in experimental allotransplantation in rodents to elaborate the most suitable model to supply the scarcity of islet donors. We used the PubMed database to systematically search for published articles containing the keywords ""rodent islet transplantation"" to review. We included studies that involved allotransplantation experiments with rodents' islets, and we reviewed the reference lists from the eligible publications that were retrieved. We excluded articles related to isotransplantation, autotransplantation and xenotransplantation, i.e., transplantation in other species. A total of 25 studies related to allotransplantation were selected for systematic review based on their relevance and updated data. Allotransplantation in rodents is promising and continues to develop. Survival rates of allografts have increased with the discovery of new immunosuppressive drugs and the use of different graft sites. These successes suggest that islet transplantation is a promising method to overcome the scarcity of islet donors and advance the treatment options for type 1 diabetes.