OLIVIA MEIRA DIAS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
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article 25 Citação(ões) na Scopus CLINICAL COURSE AND CHARACTERISATION OF LYMPHANGIOLEIOMYOMATOSIS IN A BRAZILIAN REFERENCE CENTRE(2014) BALDI, B. Guedes; SALIM, C.; FREITAS, G.; ARAUJO, M. Sponholz; DIAS, O. Meira; PEREIRA, D. A. Silva; PIMENTA, S. Pinheiro; KAIRALLA, R. A.; CARVALHO, C. R. RibeiroBackground and objective: Lymphangioleiomyomatosis (LAM) is a rare disease that promotes pulmonary cystic destruction and impairs pulmonary function. We aim to describe features and clinical course of LAM patients from Brazil. Methods: We described the clinical and functional features, performance in six minute walk test (6MWT), management details, survival and clinical course of 84 LAM patients followed in a Brazilian reference centre. Results: All subjects were women, the average age at onset of symptoms was 38 years, and the average at diagnosis was 42 years. The major symptoms during the course of the disease were dyspnoea and pneumothorax. The patients experienced impaired quality of life, with worse scores in the physical and emotional domains. The most common abnormalities in pulmonary function tests were an obstructive pattern and reduced diffusion capacity, whereas a quarter of the patients had normal spirometric results. In the 6MWT, although patients had preserved exercise capacity, more than half of the patients had significant desaturation. Hormonal blockage and doxycycline were the most common treatment modalities employed in our patients. The survival probability from diagnosis was 90% at 5 years, whereas the mean annual rate of decline in FEV1 was 60 +/- 78 mL. Conclusions: Clinical and functional features of the LAM patients from our centre are similar to those from other countries. Our sample showed preserved exercise capacity, with desaturation in the 6MWT, and impaired quality of life. Survival was similar, whereas the annual rate of decline of FEV1 was slightly lower than in recent studies.conferenceObject Evaluation and correlations of the extension of pulmonary cysts in lymphangioleiomyomatosis(2013) ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; BALDI, Bruno Guedes; TELES, Gustavo Borges da Silva; PIMENTA, Suzana Pinheiro; PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; COSTA, Andre Nathan; KAWANO-DOURADO, Leticia; KAWASSAKI, Alexandre; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro- What if my lung-dominant connective tissue disease (LD-CTD) patient eventually met criteria for a definite CTD: The role of prognosis!(2015) PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; ARAUJO, Mariana Sponholz; KAWANO-DOURADO, Leticia; FREITAS, Carolina Salim; KAWASSAKI, Alexandre De Melo; GRATZIOU, Bruno; CARVALHO, Carlos R. R.; KAIRALLA, Ronaldo Adib
conferenceObject Interstitial Lung Disease As A Marker Of Systemic Autoimmunity: Repeated Autoantibody Measure Can Uncover An Occult Connective Tissue Disease(2014) PEREIRA, D. A. S.; BALDI, B. G.; KAWASSAKI, A. M.; KAWANO-DOURADO, L.; DIAS, O. M.; FREITAS, C. S. G.; ARAUJO, M. S.; KAIRALLA, R. A.; CARVALHO, C. R. R.conferenceObject It's Not Sarcoidosis Unless The Lung Says So(2015) HOLANDA, D. V. D.; PAIVA, M.; PEREIRA, D. A. S.; DIAS, O. M.; HEIDEN, G. I.; FREITAS, C. S. G.; BALDI, B. G.; KAIRALLA, R. A.- Concentration of Serum Vascular Endothelial Growth Factor (VEGF-D) and Its Correlation with Functional and Clinical Parameters in Patients with Lymphangioleiomyomatosis from a Brazilian Reference Center(2019) AMARAL, Alexandre Franco; OLIVEIRA, Martina Rodrigues de; DIAS, Olivia Meira; ARIMURA, Fabio Eiji; FREITAS, Carolina Salim Goncalves; ACENCIO, Milena Marques Pagliarelli; ALVARENGA, Vanessa Adelia de; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro; BALDI, Bruno Guedes; SCLEROSIS, Tuberous; BALBO, Bruno Eduardo Pedroso; WATANABE, Elieser Hitoshi; SAMORANO, Luciana Paula; ONUCHIC, Luiz Fernando; RIVITTI-MACHADO, Maria Cecilia da Matta; MANREZA, Maria Luiza Giraldes de; CORDEIRO, Mauricio Dener; TAKAHASHI, Patricia; OLIVEIRA, Zilda Najjar Prado deIntroductionSerum vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that is considered a valuable tool in the diagnosis of lymphangioleiomyomatosis (LAM). Previous studies have reported a wide variability in VEGF-D serum levels in LAM patients and it seems to be associated with pulmonary impairment and lymphatic involvement.MethodsWe conducted a cross-sectional study from 2009 to 2017 that evaluated VEGF-D serum levels in a cohort of LAM patients who were never treated with mTOR inhibitors and compared them to healthy age-matched volunteers. Clinical and functional parameters were assessed and correlated with their respective serum VEGF-D levels.ResultsOne hundred and four patients were included in the analysis. Serum VEGF-D levels were higher in LAM patients compared to healthy controls: 796 (404-1588) versus 162 (117-232)pg/mL, respectively (p<0.001). Patients with tuberous sclerosis complex-LAM, TSC-LAM (20%), had higher levels of VEGF-D when compared to patients with sporadic LAM (80%) [1005 (641-2732) vs. 772 (370-1383), p=0.05]. Serum VEGF-D levels were weakly correlated with DLCO (r=-0.26, p=0.001) and lymphatic involvement was more frequent in those with serum VEGF-D levels equal or above 800pg/mL (35% vs. 13%, p=0.02).ConclusionsIn LAM, serum VEGF-D is weakly associated with lung function impairment and strongly associated with lymphatic involvement. VEGF-D is validated for use in Brazilian patients with LAM whose characteristics must be accounted for when evaluating their serum VEGF-D levels.
conferenceObject Retrospective Cohort Of Neurosarcoidosis Patients From A Reference Center In Brazil: The Underestimation Of A Relevant Feature(2014) FELISBINO, M. B.; PEREIRA, D. A. S.; COSTA, A. N.; ARAUJO, M. S.; KAWASSAKI, A. M.; FREITAS, C. S.; KAWANO-DOURADO, L.; DIAS, O. M.; BALDI, B. G.; KAIRALLA, R. A.- Association of Pulmonary Cysts and Nodules in a Young Female Patient(2016) DIAS, Olivia Meira; NASCIMENTO, Ellen Caroline Toledo do; CARVALHO, Carlos Roberto Ribeiro; ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; KAIRALLA, Ronaldo Adib; DOLHNIKOFF, Marisa; BALDI, Bruno GuedesA 27-year-old female patient was referred to our outpatient clinic with a 1-year history of shortness of breath when walking fast on level ground or when climbing stairs. Symptoms worsened after a second episode of spontaneous left pneumothorax, when a chest tube was placed in another hospital for complete lung expansion. During this hospitalization, an open lung biopsy was performed. There was no history of rhinorrhea, nasal congestion, cough, hemoptysis, wheezing, or expectoration.
conferenceObject A Retrospective Cohort Study Comparing Autoantibody Positive Idiopathic Interstitial Pneumonia Patients With And Without Extrathoracic Features Of Connective Tissue Disease(2014) PEREIRA, D. A. S.; ALMEIDA, G. E.; FREITAS, C. S.; DIAS, O. M.; ARAUJO, M. S.; KAWANO-DOURADO, L.; KAWASSAKI, A. M.; BALDI, B. G.; CARVALHO, C. R. R.; KAIRALLA, R. A.conferenceObject Survival And Decline In Lung Function In Patients With Lymphangioleiomyomatosis From A Brazilian Reference Center(2013) BALDI, B. G.; ARAUJO, M. S.; FREITAS, C. S. G.; PIMENTA, S. P.; DIAS, O. M.; PEREIRA, D. A. S.; KAIRALLA, R. A.; CARVALHO, C. R.