OLIVIA MEIRA DIAS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
- Colagenose pulmão dominante em pacientes com doença pulmonar intersticial: prevalência, estabilidade funcional e manifestações extratorácicas comuns(2015) PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; ALMEIDA, Guilherme Eler de; ARAUJO, Mariana Sponholz; KAWANO-DOURADO, Leticia Barbosa; BALDI, Bruno Guedes; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto RibeiroObjective: To describe the characteristics of a cohort of patients with lung-dominant connective tissue disease (LD-CTD). Methods: This was a retrospective study of patients with interstitial lung disease (ILD), positive antinuclear antibody (ANA) results (>= 1/320), with or without specific autoantibodies, and at least one clinical feature suggestive of connective tissue disease (CO). Results: Of the 1,998 patients screened, 52 initially met the criteria for a diagnosis of LD-CTD: 37% were male; the mean age at diagnosis was 56 years; and the median follow-up period was 48 months. During follow-up, 8 patients met the criteria for a definitive diagnosis of a CTD. The remaining 44 patients comprised the LD-CTD group, in which the most prevalent extrathoracic features were arthralgia, gastroesophageal reflux disease, and Raynaud's phenomenon. The most prevalent autoantibodies in this group were ANA (89%) and anti-SSA (anti-Ro, 27%). The mean baseline and final FVC was 69.5% and 74.0% of the predicted values, respectively (p > 0.05). Nonspecific interstitial pneumonia and usual interstitial pneumonia patterns were found in 45% and 9% of HRCT scans, respectively; 36% of the scans were unclassifiable. A similar prevalence was noted in histological samples. Diffuse esophageal dilatation was identified in 52% of HRCT scans. Nailfold capillaroscopy was performed in 22 patients; 17 showed a scleroderma pattern. Conclusions: In our LD-CTD group, there was predominance of females and the patients showed mild spirometric abnormalities at diagnosis, with differing underlying ILD patterns that were mostly unclassifiable on HRCT and by histology. We found functional stability on follow-up. Esophageal dilatation on HRCT and scleroderma pattern on nailfold capillaroscopy were frequent findings and might come to serve as diagnostic criteria.
conferenceObject High Resolution Computer Tomography Analysis Of A Cohort Of Mixed Connective Tissue Disease (mctd) Patients: 10 Years Of Follow-Up(2013) KAWANO-DOURADO, L.; DIAS, O. M.; KAY, F.; GRIPP, T.; GOMES, P.; CALEIRO, M.; KAIRALLA, R.; CARVALHO, C. R. R.conferenceObject Evaluation and correlations of the extension of pulmonary cysts in lymphangioleiomyomatosis(2013) ARAUJO, Mariana Sponholz; FREITAS, Carolina Salim Goncalves; BALDI, Bruno Guedes; TELES, Gustavo Borges da Silva; PIMENTA, Suzana Pinheiro; PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; COSTA, Andre Nathan; KAWANO-DOURADO, Leticia; KAWASSAKI, Alexandre; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto RibeiroconferenceObject 10-Year Follow-Up Of Pulmonary Function In Mixed Connective Tissue Disease(2013) KAWANO-DOURADO, L.; DIAS, O. M.; KAY, F. U.; GRIPP, T. E. H.; GOMES, P. S.; CALEIRO, M. C.; FULLER, R.; KAIRALLA, R. A.; CARVALHO, C. R. R.- What if my lung-dominant connective tissue disease (LD-CTD) patient eventually met criteria for a definite CTD: The role of prognosis!(2015) PEREIRA, Daniel Antunes Silva; DIAS, Olivia Meira; ARAUJO, Mariana Sponholz; KAWANO-DOURADO, Leticia; FREITAS, Carolina Salim; KAWASSAKI, Alexandre De Melo; GRATZIOU, Bruno; CARVALHO, Carlos R. R.; KAIRALLA, Ronaldo Adib
article 27 Citação(ões) na Scopus Pulmonary involvement in long-term mixed connective tissue disease: functional trends and imaging findings after 10 years(2015) KAWANO-DOURADO, L.; BALDI, B. G.; KAY, F. U.; DIAS, O. M.; GRIPP, T. E. H.; GOMES, P. S.; FULLER, R.; CALEIRO, M. T. C.; KAIRALLA, R. A.; CARVALHO, C. R. R.Objective Interstitial lung disease (ILD) is highly prevalent in patients with mixed connective tissue disease (MCTD). However, little is known about the long-term progression of ILD in MCTD. The aims of this study were to describe pulmonary function test (PFT) and high-resolution computed tomography (HRCT) results in long-term MCTD patients, to measure changes in PFT and HRCT results over a 10-year period, and to ascertain correlations in functional and imaging data. Methods In this retrospective cohort study, comparison between baseline and follow-up PFT and HRCT data was performed for 39 unselected consecutive MCTD patients. Results At baseline, 51% of the patients had abnormal PFTs. Forced vital capacity (FVC) was slightly reduced at baseline (77% of predicted), but remained stable after 10 years. A relative decrease of 15% in the diffusion capacity for carbon monoxide (DLco) was detected (from 84% to 71% of predicted, p<0.001). The median lower lobes ILD-HRCT score progressed from 7.5% at baseline to 11.2% at follow-up (p=0.02), and findings of traction bronchiolectasis and honeycombing increased (p<0.05). A moderate negative correlation was observed between functional parameters and quantification of image findings. Conclusion Functional and radiologic alterations suggestive of ILD in long-term MCTD patients are prevalent, mild, and progressed slightly over time. The most sensitive parameters for detecting subtle progression of ILD in MCTD patients are trends in DLco, quantification of lower-lobes disease by HRCT (lower-lobes %ILD-HRCT score), and qualitative analysis of HRCT imaging.conferenceObject Interstitial Lung Disease As A Marker Of Systemic Autoimmunity: Repeated Autoantibody Measure Can Uncover An Occult Connective Tissue Disease(2014) PEREIRA, D. A. S.; BALDI, B. G.; KAWASSAKI, A. M.; KAWANO-DOURADO, L.; DIAS, O. M.; FREITAS, C. S. G.; ARAUJO, M. S.; KAIRALLA, R. A.; CARVALHO, C. R. R.conferenceObject Features Of A Brazilian Cohort Of Patients With Lung-Dominant Connective Tissue Disease (ld-CTd)(2013) PEREIRA, D. A. S.; DIAS, O. M.; ALMEIDA, G. E.; ARAUJO, M. S.; KAWANO-DOURADO, L.; KAIRALLA, R. A.; CARVALHO, C. R. R.; BALDI, B. G.- Scattered Lung Cysts as the Main Radiographic Finding of Constrictive Bronchiolitis(2012) KAWANO-DOURADO, Leticia; BALDI, Bruno G.; DIAS, Olivia M.; BERNARDI, Fabiola D. C.; CARVALHO, Carlos R. R.; DOLHNIKOFF, Marisa; KAIRALLA, Ronald A.
conferenceObject Pulmonary Involvement In Mixed Connective Tissue Disease: Slow Progression After 10 Years Of Follow-Up(2013) KAWANO-DOURADO, Leticia; DIAS, Olivia M.; KAY, Fernando U.; GRIPP, Thais E. H.; GOMES, Paula S.; FULLER, Ricardo; BALDI, Bruno G.; KAIRALLA, Ronaldo A.; CARVALHO, Carlos R. R.; CALEIRO, M. Teresa C.