OLIVIA MEIRA DIAS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
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conferenceObject Recurrence of Sarcoid Granulomas in Lung Re-Transplant Recipient(2019) PROVENCI, B.; SERRA, J. P. C.; JESUS, R. M.; DIAS, O. M.; COSTA, A. N.- A textural approach for quantitative CT in chronic hypersensitivity pneumonitis (cHP)(2019) PENNATI, Francesca; DIAS, Olivia; ANTONIAZZA, Alessio; BERETTA, Davide; ALIBONI, Lorenzo; BALDI, Bruno Guedes; SAWAMURA, Marcio; CHATE, Rodrigo Caruso; CARVALHO, Carlos Roberto Ribeiro De; ALBUQUERQUE, Andre; ALIVERTI, Andrea
- Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis(2019) DIAS, Olivia Meira; BALDI, Bruno Guedes; CHATE, Rodrigo Caruso; CARVALHO, Carlos Roberto Ribeiro de; DELLACA, Raffaele L.; MILESI, Ilaria; ALBUQUERQUE, Andre Luis Pereira deObjective: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by the inhalation of specific organic antigens or low-molecular weight substances in genetically susceptible individuals. Although small airway involvement is prominent in patients with chronic HP, conventional pulmonary function tests (PFTs) are relatively insensitive to identify it. Thus, the authors aimed to evaluate resistance (R5) and reactance (X5) values at 5 Hz on inspiration, expiration, and whole breath, as well as small airway resistance (R5-19) values using a forced oscillation technique (FOT) in patients with chronic HP, and their responses after bronchodilator. In addition, R5 and X5 values according to the presence or absence of mosaic attenuation on computed tomography (CT) were compared. Methods: PFTs with plethysmography, diffusing capacity of the lungs for carbon monoxide (DLco) and FOT measurements were performed pre-bronchodilator and post-bronchodilator. High-resolution CT was performed at the same visit, and classified according to the presence or absence of mosaic attenuation. R5 and X5 values were then compared according to the presence or absence of mosaic attenuation on CT. Results: Twenty-eight patients with chronic HP (57.1% female; mean age, 56 +/- 11.5 years; mean forced vital capacity 57 +/- 17% predicted) were evaluated. All patients had low X5 values, reflecting lower lung compliance, and only three (8%) demonstrated elevated R5 (whole-breath) values. No patients exhibited bronchodilator response in R5, X5 and R5_19 values. In patients who exhibited greater extension of mosaic attenuation (n =11), R5 and X5 values could not discriminate those with a greater presence of these areas on CT. Conclusions: The results suggest that FOT does not help to additionally characterise concomitant small airway involvement in patients with chronic fibrotic HP who demonstrate restrictive ventilatory pattern in conventional PFTs. Nevertheless, FOT appeared to better characterise decreased lung compliance due to fibrosis through X5. Bronchodilator therapy did not appear to induce an acute response in chronic HP patients with restrictive disease. The precise role of FOT in subacute HP and obstructive chronic HP, therefore, must be evaluated.
conferenceObject An Unusual Pleural Effusion in a Patient with Heart Failure(2019) TAKIZAWA, D. B.; COLARES, P. F.; COSTA, F. M. da; BALDI, B. G.; DIAS, O. M.- Natural history of incidental sporadic or tuberous sclerosis complex associated lymphangioleiomyomatosis(2019) MARCO, Fabiano Di; TERRANEO, Silvia; DIAS, Olivia Olivia Meira; IMERI, Gianluca; CENTANNI, Stefano; GIULIANI, Lisa; LESMA, Elena; PALUMBO, Giuseppina; WANDERLEY, Mark; CARVALHO, Carlos Roberto Ribeiro; BALDI, Bruno Guedes
- Concentration of Serum Vascular Endothelial Growth Factor (VEGF-D) and Its Correlation with Functional and Clinical Parameters in Patients with Lymphangioleiomyomatosis from a Brazilian Reference Center(2019) AMARAL, Alexandre Franco; OLIVEIRA, Martina Rodrigues de; DIAS, Olivia Meira; ARIMURA, Fabio Eiji; FREITAS, Carolina Salim Goncalves; ACENCIO, Milena Marques Pagliarelli; ALVARENGA, Vanessa Adelia de; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro; BALDI, Bruno Guedes; SCLEROSIS, Tuberous; BALBO, Bruno Eduardo Pedroso; WATANABE, Elieser Hitoshi; SAMORANO, Luciana Paula; ONUCHIC, Luiz Fernando; RIVITTI-MACHADO, Maria Cecilia da Matta; MANREZA, Maria Luiza Giraldes de; CORDEIRO, Mauricio Dener; TAKAHASHI, Patricia; OLIVEIRA, Zilda Najjar Prado deIntroductionSerum vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that is considered a valuable tool in the diagnosis of lymphangioleiomyomatosis (LAM). Previous studies have reported a wide variability in VEGF-D serum levels in LAM patients and it seems to be associated with pulmonary impairment and lymphatic involvement.MethodsWe conducted a cross-sectional study from 2009 to 2017 that evaluated VEGF-D serum levels in a cohort of LAM patients who were never treated with mTOR inhibitors and compared them to healthy age-matched volunteers. Clinical and functional parameters were assessed and correlated with their respective serum VEGF-D levels.ResultsOne hundred and four patients were included in the analysis. Serum VEGF-D levels were higher in LAM patients compared to healthy controls: 796 (404-1588) versus 162 (117-232)pg/mL, respectively (p<0.001). Patients with tuberous sclerosis complex-LAM, TSC-LAM (20%), had higher levels of VEGF-D when compared to patients with sporadic LAM (80%) [1005 (641-2732) vs. 772 (370-1383), p=0.05]. Serum VEGF-D levels were weakly correlated with DLCO (r=-0.26, p=0.001) and lymphatic involvement was more frequent in those with serum VEGF-D levels equal or above 800pg/mL (35% vs. 13%, p=0.02).ConclusionsIn LAM, serum VEGF-D is weakly associated with lung function impairment and strongly associated with lymphatic involvement. VEGF-D is validated for use in Brazilian patients with LAM whose characteristics must be accounted for when evaluating their serum VEGF-D levels.
- Convolutional neural network (CNN) for interstitial lung disease (ILD) patterns recognition(2019) ALIBONI, Lorenzo; PENNATI, Francesca; DIAS, Olivia; BALDI, Bruno; SAWAMURA, Marcio; CHATE, Rodrigo; CARVALHO, Carlos Roberto De; ALIVERTI, Andrea