ANA LUCIA DE SA PINTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
- Creatine Supplementation in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial(2013) ALVES, Christiano R. R.; SANTIAGO, Bianca M.; LIMA, Fernanda R.; OTADUY, Maria C. G.; CALICH, Ana Luisa; TRITTO, Aline C. C.; PINTO, Ana Lucia de Sa; ROSCHEL, Hamilton; LEITE, Claudia C.; BENATTI, Fabiana B.; BONFA, Eloisa; GUALANO, BrunoObjective. To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients. Methods. A 16-week, randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Fibromyalgia patients were randomly assigned to receive either creatine monohydrate or placebo in a double-blind manner. The patients were evaluated at baseline and after 16 weeks. Muscle function, aerobic conditioning, cognitive function, quality of sleep, quality of life, kidney function, and adverse events were assessed. Muscle phosphorylcreatine content was measured through P-31 magnetic resonance spectroscopy. Results. After the intervention, the creatine group presented higher muscle phosphorylcreatine content when compared with the placebo group (+80.3% versus -2.7%; P = 0.04). Furthermore, the creatine group presented greater muscle strength than the placebo group in the leg press and chest press exercises (+9.8% and +1.2% for creatine versus -0.5% and -7.2% for placebo, respectively; P = 0.02 and P = 0.002, respectively). Isometric strength was greater in the creatine group than in the placebo group (+6.4% versus -3.2%; P = 0.007). However, no general changes were observed in aerobic conditioning, pain, cognitive function, quality of sleep, and quality of life. Food intake remained unaltered and no side effects were reported. Conclusion. Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower- and upper-body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.
bookPart Recomendações das atividades físicas e esportivas(2013) PINTO, Ana Lucia de Sá; PERONDI, Maria Beatriz MoliternoconferenceObject Efficacy and Safety Of Low-Intensity Resistance Training Combined With Vascular Occlusion In Polymyositis and Dermatomyositis(2013) MATTAR, Melina; PERANDINI, Luiz A.; DASSOUKI, Thalita; SHINJO, Samuel K.; GUALANO, Bruno; ROSCHEL, Hamilton; LIMA, Fernanda R.; PINTO, Ana Lucia S.- Impaired aerobic exercise capacity and cardiac autonomic control in primary antiphospholipid syndrome(2013) GARCIA, C. B.; PERANDINI, L. A.; SEGURO, L. P. C.; GUALANO, B.; ROSCHEL, H.; BONFA, E.; BORBA, E. F.; SA-PINTO, A. L.Primary antiphospholipid syndrome (PAPS) is associated with increased risk of cardiovascular disease and mortality. Aerobic capacity and cardiac autonomic control are also associated with these risks. The aim of our study was to assess aerobic capacity and cardiac autonomic control in PAPS patients. Thirteen women with PAPS and 13 healthy controls matched for age, gender, and body mass index were enrolled for the study. Both groups were sedentary and were not under chronotropic, antidepressants and hypolipemiant drugs. All subjects performed a treadmill-graded maximal exercise. Aerobic capacity was assessed by peak oxygen uptake (VO(2)peak), time at anaerobic ventilatory threshold (VAT) and respiratory compensation point (RCP) and time-to-exhaustion, whereas cardiac autonomic control was assessed by chronotropic reserve (CR) and heart rate recovery at the first and second minutes after graded exercise (HRR1min and HRR2min, respectively). All aerobic capacity indexes were reduced more in PAPS patients than in healthy subjects: VO(2)peak (30.2 +/- 4.7 vs 34.6 +/- 4.3ml.kg(-1).min(-1), p=0.021), time at VAT (3.0 +/- 1.5 vs 5.0 +/- 2.0min, p=0.016), time at RCP (6.5 +/- 2.0 vs 8.0 +/- 2.0min, p=0.050), time-to-exhaustion (8.5 +/- 2.0 vs 11.0 +/- 2.5min, p=0.010). HRR1min (22 +/- 9 vs 30 +/- 7 bpm, p=0.032) and HRR2min (33 +/- 9 vs 46 +/- 8bpm, p=0.002) were delayed in PAPS patients compared to healthy controls but CR was not significantly different (p=0.272). In conclusion, an impaired aerobic capacity and cardiac autonomic control was identified in PAPS.
- Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study(2013) ALVES, Christiano Robles Rodrigues; MEREGE FILHO, Carlos Alberto Abujabra; BENATTI, Fabiana Braga; BRUCKI, Sonia; PEREIRA, Rosa Maria R.; PINTO, Ana Lucia de Sa; LIMA, Fernanda Rodrigues; ROSCHEL, Hamilton; GUALANO, BrunoPurpose: To assess the effects of creatine supplementation, associated or not with strength training, upon emotional and cognitive measures in older woman. Methods: This is a 24-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one of the following groups (n=14 each): 1) placebo, 2) creatine supplementation, 3) placebo associated with strength training or 4) creatine supplementation associated with strength training. According to their allocation, the participants were given creatine (4 x 5 g/d for 5 days followed by 5 g/d) or placebo (dextrose at the same dosage) and were strength trained or not. Cognitive function, assessed by a comprehensive battery of tests involving memory, selective attention, and inhibitory control, and emotional measures, assessed by the Geriatric Depression Scale, were evaluated at baseline, after 12 and 24 weeks of the intervention. Muscle strength and food intake were evaluated at baseline and after 24 weeks. Results: After the 24-week intervention, both training groups (ingesting creatine supplementation and placebo) had significant reductions on the Geriatric Depression Scale scores when compared with the non-trained placebo group (p = 0.001 and p = 0.01, respectively) and the non-trained creatine group (p < 0.001 for both comparison). However, no significant differences were observed between the non-trained placebo and creatine (p = 0.60) groups, or between the trained placebo and creatine groups (p = 0.83). Both trained groups, irrespective of creatine supplementation, had better muscle strength performance than the non-trained groups. Neither strength training nor creatine supplementation altered any parameter of cognitive performance. Food intake remained unchanged. Conclusion: Creatine supplementation did not promote any significant change in cognitive function and emotional parameters in apparently healthy older individuals. In addition, strength training per se improved emotional state and muscle strength, but not cognition, with no additive effects of creatine supplementation.
- Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial(2013) PRADO, Danilo M. L.; BENATTI, Fabiana B.; SA-PINTO, Ana L. de; HAYASHI, Ana P.; GUALANO, Bruno; PEREIRA, Rosa M. R.; SALLUM, Adriana M. E.; BONFA, Eloisa; SILVA, Clovis A.; ROSCHEL, HamiltonIntroduction: Exercise training has emerged as a promising therapeutic strategy to counteract physical dysfunction in adult systemic lupus erythematosus. However, no longitudinal studies have evaluated the effects of an exercise training program in childhood-onset systemic lupus erythematosus (C-SLE) patients. The objective was to evaluate the safety and the efficacy of a supervised aerobic training program in improving the cardiorespiratory capacity in C-SLE patients. Methods: Nineteen physically inactive C-SLE patients were randomly assigned into two groups: trained (TR, n = 10, supervised moderate-intensity aerobic exercise program) and non-trained (NT, n = 9). Gender-,body mass index (BMI)- and age-matched healthy children were recruited as controls (C, n = 10) for baseline (PRE) measurements only. C-SLE patients were assessed at PRE and after 12 weeks of training (POST). Main measurements included exercise tolerance and cardiorespiratory measurements in response to a maximal exercise (that is, peak VO2, chronotropic reserve (CR), and the heart rate recovery (Delta HRR) (that is, the difference between HR at peak exercise and at both the first (Delta HRR1) and second (Delta HRR2) minutes of recovery after exercise). Results: The C-SLE NT patients did not present changes in any of the cardiorespiratory parameters at POST (P > 0.05). In contrast, the exercise training program was effective in promoting significant increases in time-to-exhaustion (P = 0.01; ES = 1.07), peak speed (P = 0.01; ES = 1.08), peak VO2 (P = 0.04; ES = 0.86), CR (P = 0.06; ES = 0.83), and in Delta HRR1 and Delta HRR2 (P = 0.003; ES = 1.29 and P = 0.0008; ES = 1.36, respectively) in the C-SLE TR when compared with the NT group. Moreover, cardiorespiratory parameters were comparable between C-SLE TR patients and C subjects after the exercise training intervention, as evidenced by the ANOVA analysis (P > 0.05, TR vs. C). SLEDAI-2K scores remained stable throughout the study. Conclusion: A 3-month aerobic exercise training was safe and capable of ameliorating the cardiorespiratory capacity and the autonomic function in C-SLE patients.
conferenceObject Exercise Training in Childhood-Onset Systemic Lupus Erythematosus: A Controlled Randomized Trial(2013) ROSCHEL, Hamilton; PRADO, Danilo M. L.; BENATTI, Fabiana B.; SA-PINTO, Ana L.; HAYASHI, Ana P.; PEREIRA, Rosa M. R.; SALLUM, Adriana M. E.; BONFA, Eloisa; SILVA, Clovis A.; GUALANO, BrunoconferenceObject Fat Mass and Resistin: Predictive Factors For Anti-TNF Therapy Response In Ankylosing Spondylitis Patients(2013) SAAD, Carla G. S.; ABREU, Andressa Silva; RIBEIRO, Ana Cristina Medeiros; MORAES, Julio C. B.; PERANDINI, Luiz A.; DASSOUKI, Thalita; PEREIRA, Rosa M. R.; BONFA, Eloisa; PINTO, Ana Lucia S.conferenceObject Inactive Systemic Lupus Erythematosus: Cytokines and Soluble Tumor Necrosis Factor Receptors Response To Moderate/Intense Exercise(2013) PERANDINI, Luiz A.; SALES-DE-OLIVEIRA, Diego; MELLO, Suzana B. V.; CAMARA, Niels O.; LIMA, Fernanda R.; BORBA, Eduardo F.; BONFA, Eloisa; SA-PINTO, Ana Lucia; ROSCHEL, Hamilton; GUALANO, BrunoconferenceObject Benefitial Effects Of a Simple Stretching Exercise Program For Patients With Ankylosing Spondylitis: A Randomized Controlled Trial(2013) GALLINARO, Andrea L.; SAAD, Carla G. S.; GOLDENSTEIN-SCHAINBERG, Claudia; SAMPAIO-BARROS, Percival D.; MORAES, Julio C. B.; ROSCHEL, Hamilton; PINTO, Ana Lucia S.; GONCALVES, Celio R.