ANA LUCIA DE SA PINTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Macro- and microvascular endothelial dysfunction and impaired shear rate in women with rheumatoid arthritis(2022) PECANHA, T.; MEIRELES, K.; PINTO, A. J.; REZENDE, D. A. N.; MAZZOLANI, B. C.; SMAIRA, F. I.; BONFIGLIOLI, K.; SA-PINTO, A. L.; LIMA, F. R.; FORJAZ, C.; GUALANO, B.; ROSCHEL, H.- Acute and post-acute COVID-19 presentations in athletes: a systematic review and meta-analysis(2022) LEMES, Italo Ribeiro; SMAIRA, Fabiana Infante; RIBEIRO, Willian J. D.; FAVERO, Natalia Koenig; MATOS, Luciana Diniz Nagem Janot; PINTO, Ana Lucia de Sa; DOLAN, Eimear; GUALANO, BrunoObjective To describe acute/postacute COVID-19 presentations in athletes. Design Systematic review and meta-analysis. Data sources The search was conducted in four databases (MEDLINE, EMBASE, SCOPUS, SPORTDiscus) and restricted to studies published from 2019 to 6 January 2022. Eligibility criteria for selecting studies Studies were required to (1) include professional, amateur or collegiate/university athletes with COVID-19; (2) present data on acute/postacute COVID-19 symptoms and (3) have an observational design. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal tools. Results 43 studies with 11 518 athletes were included. For acute presentation, the pooled event rates for asymptomatic and severe COVID-19 were 25.5% (95% CI: 21.1% to 30.5%) and 1.3% (95% CI: 0.7% to 2.3%), respectively. For postacute presentations, the pooled estimate of persistent symptoms was 8.3% (95% CI: 3.8% to 17.0%). Pooled estimate for myocardial involvement was 5.0% (95% CI: 2.5% to 9.8%) in athletes undergoing any cardiac testing, and 2.5% (95% CI: 1.0% to 5.8%) in athletes undergoing MRI, although clinical symptoms were not characterised. None of the studies with a control group (eg, non-infected athletes) could confirm a causal relationship between COVID-19 and myocardial involvement. Conclusion This broad characterisation of COVID-19 presentations in athletes indicates that similar to 94% exhibited mild or no acute symptoms. The available evidence did not confirm a causal relationship between COVID-19 and myocardial involvement. A small proportion of athletes experienced persistent symptoms while recovering from infection, which were mostly mild in nature, but could affect return-to-play decisions and timing.
- High SARS-CoV-2 infection rate after resuming professional football in Sao Paulo, Brazil(2022) GUALANO, Bruno; BRITO, Gisele Mendes; PINTO, Ana Jessica; LEMES, Italo Ribeiro; MATOS, Luciana Diniz Nagem Janot; PINTO, Ana Lucia de Sa; LOTURCO, IrineuObjective To examine the SARS-CoV-2 infection rate in a cohort of 6500 professional athletes and staff during the 2020 football (soccer) season in Sao Paulo, Brazil. Methods This retrospective cohort study included 4269 players (87% male, age: 21.7 +/- 4.2 years) and 2231 staff (87% male, age: 42.6 +/- 11.9 years) from 122 teams (women: n=16) involved in eight leagues (women: n=2), which took place in Sao Paulo, Brazil. Between 4 July 2020 and 21 December 2020, swab samples were collected weekly (n=29 507) and tested for SARS-Cov-2 via reverse transcription-PCR by an accredited laboratory commissioned by the Sao Paulo Football Federation. We contacted the medical staff of each team with positive cases to collect information on disease severity. Results Among 662 PCR-confirmed cases, 501 were athletes and 161 were staff. The new infection rate was 11.7% and 7.2% for athletes and staff, respectively. Athletes were more susceptible to infection than staff (OR: 1.71, 95% CI: 1.42, 2.06, p<0.001), although with lower chance for moderate to severe disease (OR: 0.06, 95% CI: 0.01, 0.54, p=0.012). Six teams had >= 20 individuals testing positive for SARS-CoV-2, whereas 19 teams had >= 10 confirmed cases. Twenty-five mass outbreaks were identified (>= 5 infections within a team in a 2-week period). The prevalence of SARS-CoV-2 infections was similar in athletes and staff as the general population in Sao Paulo. Conclusion Despite weekly testing and other preventive measures, we found a high SARS-CoV-2 infection rate in athletes and staff after resuming football, which coincides with the high prevalence of infection in the community during the same period. These data may assist policy-makers and sports federations for determining if and when it is safe to resume competitions.
- Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases? (vol 16, pg 667, 2017)(2022) PINTO, Ana Jessica; ROSCHEL, Hamilton; PINTO, Ana Luciade Sa; LIMA, Fernanda Rodrigues; PEREIRA, Rosa Maria Rodrigues; SILVA, Clovis Artur; BONFA, Eloisa; GUALANO, Bruno