MARIETA CABRAL AMARAL DA CUNHA

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LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Respiratory System ×

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  • conferenceObject
    Clinical, demographic and functional evaluation of patients with hypersensitivity pneumonitis and their comparison based on current diagnostic criteria
    (2023) BRIDI, Guilherme Das Posses; SILVA, Bianca Freire Da; CUNHA, Marieta Cabral Amaral Da; QUEIROZ, Douglas Silva; ALVES- JR., Jose Leonidas; SALGE, Joao Marcos; CARVALHO, Celso R. F. De; KAIRALLA, Ronaldo Adib; SOUZA, Rogerio De; BALDI, Bruno Guedes
  • conferenceObject
    Aging predictive factors for oxygenation response and mortality in COVID-19 and acute respiratory distress syndrome (ARDS) patients exposed to prone position: A multicenter cohort study
    (2023) CABRAL, Marieta; CUNHA, Amaral; LUNARDI, Adriana C.; SCHARDONG, Jociane; RIGHI, Natiele C.; SANT'ANNA, Guadalupe N.; ISENSEE, Larissa P.; XAVIER, Rafaela F.; POMPEU, Jose E.; WEIGERT, Ranata M.; MATTE, Darlan L.; CARDOSO, Rozana A.; ABRAS, Ana C. V.; SILVA, Antonio M. V.; DORNELES, Camila C.; WERLE, Roberta W.; STARKE, Ana C.; PLENTZ, Rodrigo D. M.; FERREIRA, Juliana C.; CARVALHO, Celso R. F.
  • conferenceObject
    Prone positioning in patients with COVID-19 under invasive mechanical ventilation and acute respiratory distress syndrome: a multicenter cohort study
    (2021) CUNHA, Marieta Cabral Amaral; PLENTZ, Rodrigo Della Mea; SANT'ANNA, Guadalupe Nery De; LUNARDI, Adriana Claudia; ISENSEE, Larissa Padrao; XAVIER, Rafaella Fagundes; SCHARDONG, Jociane; RIGHI, Natiele Camponogara; FERREIRA, Juliana Carvalho; CARVALHO, Celso Ricardo Fernandes
  • article 7 Citação(ões) na Scopus
    Impact of prone positioning on patients with COVID-19 and ARDS on invasive mechanical ventilation: a multicenter cohort study
    (2022) CUNHA, Marieta C. A.; SCHARDONG, Jociane; RIGHI, Natiele Camponogara; LUNARDI, Adriana Claudia; SANT'ANNA, Guadalupe Nery de; ISENSEE, Larissa Padrao; XAVIER, Rafaella Fagundes; BRAMBATTI, Kaciane Roberta; POMPEU, Jose Eduardo; FRANCIO, Fabiano; FARIA, Luiza Martins; CARDOSO, Rozana Astolfi; SILVA, Antonio Marcos Vargas da; DORNELES, Camila de Christo; WERLE, Roberta Weber; FERREIRA, Juliana Carvalho; PLENTZ, Rodrigo Della Mea; CARVALHO, Celso R. F.
    Objective: To identify factors that lead to a positive oxygenation response and predictive factors of mortality after prone positioning. Methods: This was a retrospective, multicenter, cohort study involving seven hospitals in Brazil. Inclusion criteria were being > 18 years of age with a suspected or confirmed diagnosis of COVID-19, being on invasive mechanical ventilation, having a PaO2/FIO2 ratio < 150 mmHg, and being submitted to prone positioning. After the first prone positioning session, a 20 mmHg improvement in the PaO2/FIO2 ratio was defined as a positive response. Results: The study involved 574 patients, 412 (72%) of whom responded positively to the first prone positioning session. Multiple logistic regression showed that responders had lower Simplified Acute Physiology Score III (SAPS III)/SOFA scores and lower D-dimer levels (p = 0.01; p = 0.04; and p = 0.04, respectively). It was suggested that initial SAPS III and initial PaO2/FIO2 were predictors of oxygenation response. The mortality rate was 69.3%. Increased risk of mortality was associated with age (OR = 1.04 [95 CI: 1.01-1.06]), time to first prone positioning session (OR = 1.18 [95 CI: 1.06-1.31]), number of sessions (OR = 1.31 [95% CI: 1.00-1.72]), proportion of pulmonary impairment (OR = 1.55 [95% CI: 1.02-2.35]), and immunosuppression (OR = 3.83 [95% CI: 1.35-10.86]). Conclusions: Our results show that most patients in our sample had a positive oxygenation response after the first prone positioning session. However, the mortality rate was high, probably due to the health status and the number of comorbidities of the patients, as well as the severity of their disease. Our results also suggest that SAPS III and the initial PaO2 /FIO2 predict the oxygenation response; in addition, age, time to first prone positioning, number of sessions, pulmonary impairment, and immunosuppression can predict mortality.
  • conferenceObject
    Effects of an online behaviour change intervention to promote physical activity in adults with asthma: preliminary data of a randomized controlled trial
    (2023) OLIVEIRA, Joice Mara; PEDROSO, Ariele; CORREIA, Natielly Soares; MELO, Denner Ildemar Feitosa; BIDOIA, Caroline Sydloski; PITTA, Fabio; KARLOH, Manuela; MATIAS, Thiago Sousa; LIMA, Fabiano Francisco; CUNHA, Marieta Cabral Amaral Da; CARVALHO, Celso R. F.; FURLANETTO, Karina Couto