IOLANDA DE FATIMA LOPES CALVO TIBERIO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
90 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 90
- Effects of melatonin in an Asthma-COPD overlap model(2023) RIBEIRO, Cristiane; SCHEFFER, Vitorio; CAMARGO, Leandro; FUKUZAKI, Silvia; ALMEIDA, Francine; RIGHETTI, Renato; TIBERIO, Iolanda; LEICK, Edna
- Stress amplifies lung tissue mechanics, inflammation and oxidative stress induced by chronic inflammation(2012) REIS, Fabiana G.; MARQUES, Ricardo H.; STARLING, Claudia M.; ALMEIDA-REIS, Rafael; VIEIRA, Rodolfo P.; CABIDO, Claudia T.; SILVA, Luiz Fernando F.; LANCAS, Tatiana; DOLHNIKOFF, Marisa; MARTINS, Milton A.; LEICK-MALDONADO, Edna A.; PRADO, CarlaM.; TIBERIO, Iolanda F. L. C.Background: Mechanisms linking behavioral stress and inflammation are poorly understood, mainly in distal lung tissue. Objective: We have investigated whether the forced swim stress (FS) could modulate lung tissue mechanics, iNOS, cytokines, oxidative stress activation, eosinophilic recruitment, and remodeling in guinea pigs (GP) with chronic pulmonary inflammation. Methods: The GP were exposed to ovalbumin or saline aerosols (2x/wk/4wks, OVA, and SAL). Twenty-four hours after the 4th inhalation, the GP were submitted to the FS protocol (5x/wk/2wks, SAL-S, and OVA-S). Seventy-two hours after the 7th inhalation, lung strips were cut and tissue resistance (Rt) and elastance (Et) were obtained (at baseline and after OVA and Ach challenge). Strips were submitted to histopathological evaluation. Results: The adrenals' weight, the serum cortisol, and the catecholamines were measured. There was an increase in IL-2, IL-5, IL-13, IFN-gamma, iNOS, 8-iso-PGF2 alpha, and in %Rt and %Et after Ach challenge in the SAL-S group compared to the SAL one. The OVA-S group has had an increase in %Rt and %Et after the OVA challenge, in %Et after the Ach and in IL-4, 8-iso-PGF2 alpha, and actin compared to the OVA. Adrenal weight and cortisol serum were increased in stressed animals compared to nonstressed ones, and the catecholamines were unaltered. Conclusion & clinical relevance: Repeated stress has increased distal lung constriction, which was associated with an increase of actin, IL-4, and 8-iso-PGF2 alpha levels. Stress has also induced an activation of iNOS, cytokines, and oxidative stress pathways.
conferenceObject Plant proteinase from Bauhinia bauhinioides Kallikrein inhibitor (BbKI) attenuates mechanics, inflammation and remodelling induced by elastase in mice(2012) OLIVEIRA, Bruno Martins; ALMEIDA-REIS, Rafael; THEODORO, Osmar A.; OLIVA, Leandro V.; RODRIGUES, Daniel Flisch; PINHEIRO, Nathalia; OLIVA, Maria L. V.; PRADO, Carla M.; MARTINS, Milton M.; TIBERIO, Iolanda F. L. C.- Green Areas and PM2,5 exposure could be associated with Asthma and COPD?(2023) ALMEIDA, Francine Maria; MOREIRA, Tiana Carla Lopes; OLIVEIRA, Lucas Miranda; RIGHETTI, Renato Fraga; LOPES, Fernanda Degobbi Tenorio Quirino Santos; ALENCAR, Airlane P.; GOUVEIA, Nelson; MAUAD, Thais; LOTUFO, Paulo A.; BENSENOR, Isabela; SANTOS, Itamar Souza; TIBERIO, Iolanda Fatima Lopes Calvo
- Alpha-7 nicotinic receptor stimulation reduces airway inflammation in a murine model of asthma(2016) SANTANA, Fernanda Paula Roncon; MIRANDA, Claudia Jeane Claudino de Pontes; PINHEIRO, Nathalia Montouro; PERINI, Adenir; CAPERUTO, Luciana Chagas; TIBERIO, Iolanda de Fatima Lopes Calvo; PRADO, Marco Antonio Maximo; MARTINS, Milton de Arruda; PRADO, Vania Ferreira; PRADO, Carla Maximo
- Effects of anti-IL 17 on inflammation in Asthma, COPD and Asthma-COPD models(2022) ALMEIDA, F. M.; CAMARGO, L. N.; MARTINS, N.; LOURENCO, J. D.; BEZERRA, S. K. M.; SARAIVA-ROMANHOLO, B.; LEICK, E. A.; LOPES, F. D. Q. S.; PRADO, C. M.; RIGHETTI, R. F.; TIBERIO, I. F. L. C.
- Treatment with proteinase inhibitor from Enterolobium contortisiliquum in mice with asthma-COPD(2020) BARBOSA, Jessica Anastacia Silva; SILVA, Luana Laura Sales Da; JOAO, Juliana Morelli Lopes Goncalves; SANTOS, Tabata Maruyama Dos; CAMARGO, Leandro Nascimento; CAMPOS, Elaine Cristina De; GALLI, Thiago Tafarel; SARAIVA-ROMANHOLO, Beatriz Mangueira; BEZERRA, Suellen Karoline Moreira; HAMAGUCHI, Sara Sumie Sobral; LEICK, Edna Aparecida; PRADO, Carla Maximo; MARTINS, Milton De Arruda; OLIVO, Maria Luiza Vilela; RIGHETTI, Renato Fraga; TIBERIO, Iolanda De Fatima Lopes Calvo
conferenceObject Therapeutic Effect of Melatonin on Pulmonary Inflammatory Response in Experimental Models of Asthma, COPD and Asthma-COPD Overlap(2022) SCHEFFER, V.; RIBEIRO, C.; CAMARGO, L.; FUKUZAKI, S.; RIGHETTI, R.; BEZERRA, S.; SARAIVA-ROMANHOLO, B.; ALMEIDA, F.; TIBERIO, I.; LEICK, E.conferenceObject Effect Of Proteinase Inhibitor Of Plant Origin Cratabl In An Experimental Model Of Chronic Allergic Pulmonary Inflammation(2014) SANTOS, A. S. A. Dos; RODRIGUES, A. P. D.; ARANTES-COSTA, F. M.; SARAIVA-ROMANHOLO, B. M.; FILHO, G. G. N.; LEICK, E. A.; MARTINS, M. A.; TIBERIO, I. D. F. L. C.conferenceObject The Role of Alpha 7 Nicotinic Receptor on Lung Alterations in an Experimental Model of Emphysema Induced by Elastase(2019) BANZATO, R. S.; SANTANA, F. P. R.; OLIVO, C. R.; LOPES, F. D. Q. S.; TIBERIO, I. F. L. C.; PRADO, M. A. M.; PRADO, V. F.; PRADO, C. M.