MARCOS BOULOS
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina - Docente
LIM/49 - Laboratório de Protozoologia, Hospital das Clínicas, Faculdade de Medicina
LIM/49 - Laboratório de Protozoologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Twenty years of successful academic outreach at Nucleo de Medicina Tropical (NACE-NUMETROP/USP) in Santarem, Para(2021) SAID, Renato do Carmo; ASSY, Joao Guilherme Pontes Lima; SILVA, Kamila Vieira; BRANDAO, Alisson dos Santos; PINHEIRO, Olivia Campos; ESPER, Helena Rangel; GRYSCHEK, Anna Luiza de Fatima Pinho Lins; BERTOLOZZI, Maria Rita; AMATO, Valdir Sabbaga; BOULOS, Marcos; SEGURADO, Aluisio Augusto Cotrim; GRYSCHEK, Ronaldo Cesar Borges; FRANCA, Francisco Oscar de Siqueira
- Unexpected detection of Plasmodium vivax and Plasmodium falciparum DNA in asymptomatic blood donors: fact or artifact?(2014) MENDRONE JR., Alfredo; CERUTTI JR., Crispim; LEVI, Jose Eduardo; BOULOS, Marcos; SANCHEZ, Maria Carmen Arroyo; MALAFRONTE, Rosely dos Santos; SANTI, Silvia Maria Di; ODONE JR., VicenteA study searching for Plasmodium vivax and Plasmodium falciparum DNA among blood donors from the non-endemic area in Brazil reported a rate of 7.41%. This number is at least three times higher than what has been observed in blood donors from the Amazon, an endemic area concentrating >99% of all malaria cases in Brazil. Moreover, the majority of the donors were supposedly infected by P. falciparum, a rare finding both in men and anophelines from the Atlantic forest. These findings shall be taken with caution since they disagree with several publications in the literature and possibly overestimate the actual risk of malaria transmission by blood transfusion in Sao Paulo city.
- Dr. Vicente Amato (*1927 dagger 2018) Obituary(2019) BOULOS, Marcos
- Effect of artesunate-mefloquine fixed-dose combination in malaria transmission in amazon basin communities(2012) Santelli, Ana C.; Ribeiro, Isabela; Daher, Andre; Boulos, Marcos; Marchesini, Paola B.; dos Santos, Roseli La Corte; Lucena, Marize B. F.; Magalhaes, Izanelda; Leon, Antonio P.; Junger, Washington; Ladislau, Jose L. B.Background: Studies in South-East Asia have suggested that early diagnosis and treatment with artesunate (AS) and mefloquine (MQ) combination therapy may reduce the transmission of Plasmodium falciparum malaria and the progression of MQ resistance. Methods: The effectiveness of a fixed-dose combination of AS and MQ (ASMQ) in reducing malaria transmission was tested in isolated communities of the Jurua valley in the Amazon region. Priority municipalities within the Brazilian Legal Amazon area were selected according to pre-specified criteria. Routine national malaria control programmatic procedures were followed. Existing health structures were reinforced and health care workers were trained to treat with ASMQ all confirmed falciparum malaria cases that match inclusion criteria. A local pharmacovigilance structure was implemented. Incidence of malaria and hospitalizations were recorded two years before, during, and after the fixed-dose ASMQ intervention. In total, between July 2006 and December 2008, 23,845 patients received ASMQ. Two statistical modelling approaches were applied to monthly time series of P. falciparum malaria incidence rates, P. falciparum/Plasmodium vivax infection ratio, and malaria hospital admissions rates. All the time series ranged from January 2004 to December 2008, whilst the intervention period span from July 2006 to December 2008. Results: The ASMQ intervention had a highly significant impact on the mean level of each time series, adjusted for trend and season, of 0.34 (95% CI 0.20 - 0.58) for the P. falciparum malaria incidence rates, 0.67 (95% CI 0.50 - 0.89) for the P. falciparum/P. vivax infection ratio, and 0.53 (95% CI 0.41 - 0.69) for the hospital admission rates. There was also a significant change in the seasonal (or monthly) pattern of the time series before and after intervention, with the elimination of the malaria seasonal peak in the rainy months of the years following the introduction of ASMQ. No serious adverse events relating to the use of fixed-dose ASMQ were reported. Conclusions: In the remote region of the Jurua valley, the early detection of malaria by health care workers and treatment with fixed-dose ASMQ was feasible and efficacious, and significantly reduced the incidence and morbidity of P. falciparum malaria.