PATRICIA DUARTE FREITAS
Projetos de Pesquisa
Unidades Organizacionais
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Fat mass to fat-free mass ratio and its associations with clinical characteristics in asthma(2022) RUGILA, Diery Fernandes; OLIVEIRA, Joice Mara; MACHADO, Felipe Vilaca Cavallari; CORREIA, Natielly Soares; PUZZI, Vitoria Cavalheiro; PASSOS, Natalia Febrini Piassi; FREITAS, Patricia Duarte; PITTA, Fabio; CARVALHO, Celso Ricardo Fernandes; FURLANETTO, Karina CoutoBackground: Fat mass to fat-free mass ratio (FM/FFM) assesses the combined effect of the balance between fat mass and fat-free mass. Aims: to evaluate the associations beetween FM/FFM and clinical outcomes in asthma and to compare clinical characteristics between individuals with higher and lower FM/FFM. Methods: 128 participants with asthma underwent anthropometric, spirometry and bioelectrical impedance assessments. Physical activity in daily life (PADL) was assessed by the Actigraph for 7 days. Daily dose of inhaled medication, steps of pharmacological treatment, Asthma Control Questionnaire, Asthma Quality of Life Questionnaire and Hospital Anxiety and Depression Scale were also assessed. Participants were classified into two groups according to the 50th percentile of reference values for FM/FFM. Results: Individuals with higher FM/FFM (n=75) used higher daily doses of inhaled corticosteroids, had worse lung function and fewer steps/day when compared to those with lower FM/FFM (n=53) (P <= 0.021). Associations were found between absolute values of FM/FFM with lung function (FEV1 and FVC [liters]): R-2=0.207 and 0.364;P<0.0001), and between the categories of lower or higher FM/FFM with steps of medication treatment (Cramer's V=0.218;P=0.016) and level of PADL (Cramer's V=0.236;P=0.009). The highest FM/FFM was a determining factor of physical inactivity (OR: 3.21;95%CI:1.17-8.78) and highest steps of pharmacological treatment (OR: 8.89;95%CI:1.23-64.08). Conclusion: Higher FM/FFM is significantly associated with worse clinical characteristics in individuals with asthma, such as higher doses of inhaled corticosteroids, worse lung function and fewer steps/day. Moreover, higher FM/FFM is a determining factor of physical inactivity and the highest steps of pharmacological treatment for asthma.
- An online behavior change intervention to promote physical activity in adults with asthma: study protocol for a multicenter randomized controlled trial(2022) OLIVEIRA, Joice Mara de; KARLOH, Manuela; MATIAS, Thiago Sousa; BARBOSA, Graziele Besen; FREITAS, Patricia Duarte; CARVALHO, Celso R. F.; FURLANETTO, Karina CoutoBackground: Behavior change interventions have been the focus of recent studies, and the COVID-19 pandemic highlighted the importance of online interventions. However, no previous studies have investigated behavior change techniques to improve physical activity in adults with asthma through online intervention. Methods: This double-blind clinical trial will investigate the effectiveness of an online behavior change intervention in increasing physical activity and reducing sedentary behavior in adults with asthma, as well as in improving other clinical outcomes in short and medium terms. Patients with clinically stable moderate to severe asthma, who are physically inactive and do not have cardiovascular and/or osteoneuromuscular impairments will be randomized into control or intervention groups (23 in each). Both groups will carry out an online educational program (1 h). Additionally, the intervention group will receive weekly individual online sessions for 12 weeks of motivation-based behavior change intervention to promote an increase in physical activity and reduce sedentary behavior based on both self-determination theory and transtheoretical model. The intervention group will also receive an activity monitor with specific strategies related to it. Both groups will be reassessed immediately after the intervention and 6 months after that. The primary outcomes are physical activity and sedentary behavior, which will be objectively assessed by a triaxial accelerometer (Actigraph wGT3X-BT). Secondary outcomes are Asthma Control Questionnaire, Incremental Step Test, Sit-To-Stand, Timed Up-and-Go, 4-Metre Gait Speed, Asthma Quality of Life Questionnaire, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Actiwatch 2, and the Hospital Anxiety and Depression Scale. Discussion: The intervention is unprecedented and was carefully developed to joint most characteristics and techniques of both behavioral strategies (transtheoretical model and self-determination theory). Therefore, this intervention has the potential to improve physical activity levels and asthma management and reduce sedentary behavior. As a consequence, this novel intervention will improve global health in this population and support its use in clinical practice. The intervention will be carried out online with direct weekly contact with the therapist. Consequently, it has low implementation costs, might improve patient's attendance, and has the potential to be largely offered elsewhere.
- Behavior change to increase physical activity reduces sleep disturbances in asthma: A randomized controlled trial(2022) FREITAS, P.; PASSOS, N. F.; CUKIER, A.; CARVALHO-PINTO, R.; CARVALHO, C. R. Fernandes de
- Characteristics of individuals with moderate to severe asthma who better respond to aerobic training: a cluster analysis(2022) LUNARDI, A.; FREITAS, P.; ENDRIGUE, T.; SILVA, R.; MENDES, F.; FRANCA, A.; CARVALHO-PINTO, R.; CARVALHO, R. Fernandes de