CLEUSA FUMICA HIRATA TAKAKURA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Detection of Toxoplasma gondii in two southern Wooly spider monkeys (Brachyteles arachnoides - Geoffroy, 1806) from the Rio de Janeiro primate center, Brazil(2014) SANTOS, S. V.; STREFEZZI, R. F.; PISSINATTI, A.; KANAMURA, C. T.; TAKAKURA, C. F. H.; DUARTE, M. I. S.; CATAO-DIAS, J. L.BackgroundToxoplasmosis led to the death of two Brachyteles arachnoides, an endangered atelid. MethodsThe diagnosis was established by necropsy, histopathological, immunohistochemical and ultrastructural changes. ResultsThe analysis confirms the presence of Toxoplasma gondii. ConclusionsThis report contributes to the development of protocols for health surveillance on maintenance and conservation of southern muriquis.
- Toxoplasmosis in a Guiana dolphin (Sotalia guianensis) from Parana, Brazil(2013) GONZALES-VIERA, O.; MARIGO, J.; RUOPPOLO, V.; ROSAS, F. C. W.; KANAMURA, C. T.; TAKAKURA, C.; FERNANDEZ, A.; CATAO-DIAS, J. L.This study describes toxoplasmosis in a by caught Guiana dolphin (Sotalia guinensis) from Paranagua Bay, Parana, Brazil. Interstitial pneumonia, multisystemic arteritis, multifocal adrenalitis and hepatitis were the primary lesions observed. These tissues had moderate to severe necrosis and mononuclear cells infiltration usually surrounded by tachyzoites and tissue cysts. Moderate lymphoid depletion was evident in the spleen. Toxoplasma gondii was positive by immunohistochemical and ultrastructural evaluation. Furthermore, the animal was negative for Morbillivirus by immunohistochemistry and had low levels of persistent organochlorines. There is evidence of environmental changes in the Paranagua Bay that could justify the occurrence of toxoplasmosis in Guiana dolphin. The sewage run-off from main urban areas and the presence of domestic and wild felids in areas surrounding the bay could be a source of T. gondii oocysts from land to sea. Based on its habitat, the authors recommend this dolphin species as sentinels for the health of bays and estuaries where they occur. Crown
- Yellow fever and orthotopic liver transplantation: new insights from the autopsy room for an old but re-emerging disease(2019) DUARTE-NETO, Amaro N.; CUNHA, Marielton dos P.; MARCILIO, Izabel; SONG, Alice T. W.; MARTINO, Rodrigo B. de; HO, Yeh-Li; POUR, Shahab Z.; DOLHNIKOFF, Marisa; SALDIVA, Paulo H. N.; DUARTE, Maria I. S.; TAKAKURA, Cleusa F.; LIMA, Fabiana R.; TANIGAWA, Ryan Y.; IGLEZIAS, Silvia D'A; KANAMURA, Cristina T.; SANTOS, Angela B. G. dos; PERONDI, Beatriz; ZANOTTO, Paolo M. de A.; D'ALBUQUERQUE, Luiz A. C.; ALVES, Venancio A. F.Aims The clinical spectrum of yellow fever (YF) ranges from asymptomatic to fulminant hepatitis. During the sylvatic YF epidemic in the metropolitan area of Sao Paulo, Brazil in 2018, seven orthotopic liver transplantations (OLTs) were performed in our institution to treat fulminant YF hepatitis. Three patients recovered, while four patients died following OLT. The autopsy findings of all these cases are presented herein as the first description of YF in transplanted patients. Methods and results All patients were men, aged 16-40 years, without vaccination to YF virus (YFV). All organs were examined, with tissue sampling for histopathological analysis. Detection of YF virus antigens (YFV Ag) was performed with two primary antibodies (mouse polyclonal anti-YFV antibody directed to wild strain and a goat anti-YF virus antibody), and RT-PCR assays were utilised to detect YFV-RNA. All the cases depicted typical findings of YF hepatitis in the engrafted liver. The main extrahepatic findings were cerebral oedema, pulmonary haemorrhage, pneumonia, acute tubular necrosis and ischaemic/reperfusion pancreatitis. Of the four cases, the YVF Ag was detected in the heart in one case, liver and testis in three cases, and the kidney and spleen in all four cases. All four cases had YF virus RNA detected by RT-PCR in the liver and in other organs. Conclusions Infection of the engrafted liver and other organs by YFV, possibly combined with major ischaemic systemic lesions, may have led to the death of four of the seven patients undergoing OLT.
- Respiratory syncytial virus (RSV) pneumonia in a southern muriqui (Brachyteles arachnoides)(2012) SANTOS, S. V.; STREFEZZI, R. F.; PISSINATTI, A.; TAKAKURA, C. F. H.; KANAMURA, C.; DUARTE, M. I. S.; CATAO-DIAS, J. L.Background An adult male Brachyteles arachanoides, kept in captivity since 1990, was found dead without apparent clinical evidence. Methods Necropsy report, histopathology, immunohistochemistry, and ultrastructural examination were conducted. Results Pulmonary syncytial cells were positive for respiratory syncytial virus (RSV), and ultrastructural examination revealed viral particles inside macrophages compatible with the Paramyxoviridae family. Conclusions Muriquis are susceptible to RSV pneumonia followed by respiratory distress syndrome and death.