KAROLINA GOUVEIA CESAR

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: CLAUDIA SELLITTO PORTO × Autor e Coautores FMUSP-HC Normalizados: LETICIA LESSA MANSUR × Assunto: Geriatrics & Gerontology ×

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  • article 13 Citação(ões) na Scopus
    Primary progressive aphasia: Classification of variants in 100 consecutive Brazilian cases
    (2013) SENAHA, Mirna Lie Hosogi; CARAMELLI, Paulo; BRUCKI, Sonia M.D.; SMID, Jerusa; TAKADA, Leonel T.; PORTO, Claudia S.; CÉSAR, Karolina G.; MATIOLI, Maria Niures P.; SOARES, Roger T.; MANSUR, Letícia L.; NITRINI, Ricardo
    ABSTRACT Primary progressive aphasia (PPA) is a neurodegenerative clinical syndrome characterized primarily by progressive language impairment. Recently, consensus diagnostic criteria were published for the diagnosis and classification of variants of PPA. The currently recognized variants are nonfluent/agrammatic (PPA-G), logopenic (PPA-L) and semantic (PPA-S). Objective: To analyze the demographic data and the clinical classification of 100 PPA cases. Methods: Data from 100 PPA patients who were consecutively evaluated between 1999 and 2012 were analyzed. The patients underwent neurological, cognitive and language evaluation. The cases were classified according to the proposed variants, using predominantly the guidelines proposed in the consensus diagnostic criteria from 2011. Results: The sample consisted of 57 women and 43 men, aged at onset 67.2±8.1 years (range of between 53 and 83 years). Thirty-five patients presented PPA-S, 29 PPA-G and 16 PPA-L. It was not possible to classify 20% of the cases into any one of the proposed variants. Conclusion: It was possible to classify 80% of the sample into one of the three PPA variants proposed. Perhaps the consensus classification requires some adjustments to accommodate cases that do not fit into any of the variants and to avoid overlap where cases fit more than one variant. Nonetheless, the established current guidelines are a useful tool to address the classification and diagnosis of PPA and are also of great value in standardizing terminologies to improve consistency across studies from different research centers.