ANTONIO DE PADUA MANSUR
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
15 resultados
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conferenceObject Multiple thrombogenic and atherogenic markers were involved in premature coronary artery disease(2012) MANSUR, A. P.; TAKADA, J. Y.; STRUNZ, C. M. C.; AVAKIAN, S. D.; CESAR, L. A. M.; RAMIRES, J. A. F.Atherogenic and thrombogenic factors are implicated in the pathogenesis of coronary artery disease (CAD). Polymorphisms in the lymphotoxin-alfa (LTA) gene, a pro-inflammatory cytokine, have been also associated with susceptibility to myocardial infarction, but results in different studies are conflicting. We examined the association of atherothrombotic markers and the LTA promoter A252G polymorphism with risk of premature CAD. Methods: A case-control study was conducted in 336 patients with documented premature CAD and 189 unrelated health controls both with less than 50 years old. Clinical characteristics and laboratorial data which included thrombogenic factors (fibrinogen, protein C, protein S and antithrombin III); and atherogenic factors (fasting glucose, lipid profile; lipoprotein (a), apolipoproteins AI and B fractions) were evaluated. Genetic variability of LTA was determined by polymerase chain reaction. Results: Male, history of premature CAD, smoking status, diabetes, hypertension and dyslipidemia were significantly more prevalent in the CAD group. Compared with controls, CAD cases had significantly lower mean concentrations of apolipoprotein AI (1.34±0.21 vs 1.23±0.22 mg/dL;<0.01), HDL-cholesterol (46.4±11.9 vs 41.1±11.2 mg/dL; p<0.01) and antithrombin III(100±12.7 vs 94.2±17.8%; p=0.02), and higher plasma concentration of fasting glucose (103.3±26.9 vs 112.1±45.3 mg/dL; p<0.01) and Lipoprotein (a) levels(32.8±32.6 vs 50.1±49.2 mg/dL; p<0.01). The LTA A252G polymorphism frequency for AA, AG and GG was respectively 55.0%, 37,6%, and 7.4% for control group and 42.7%, 46.0% and 11.3% for patients group (p=0.02). A multivariable logistic regression analysis showed that hypertension (OR 2.19 95% CI 1.290-3.716), smoker (OR 2.18; 95% CI 1.455-3.277), dyslipidemia (OR 1.94; 95% CI1.233-3.072), family history (OR 7.13; 95% CI 4.383-11.606) and LTA polymorphism (OR 1.88; 95% CI 1.193-2.972) were independent risk factors for susceptibility to CAD. LTA mutant was risk marker for CAD only in male without the traditional risk factors. Conclusions: Worse traditional risk factors profile and atherothrombogenic markers were associated with susceptibility to premature CAD. LTA mutant allelic was independently associated with premature CAD in male in the absence of traditional risk factors. Premature CAD was associated with worse clinical and laboratory multimarkers.conferenceObject Biochemical markers of muscle damage in women and men treated with statins(2017) NOGUEIRA, A.; ROGGERIO, A.; STRUNZ, C. M. C.; MANSUR, A. P.conferenceObject Randomized study of 30 days of resveratrol and caloric restriction on serum levels of sirtuin-1 in healthy subjects(2015) MANSUR, A. P.; ROGGERIO, A.; GOES, M. F. S.; TAKADA, J. Y.; AVAKIAN, S. D.; STRUNZ, C. M. C.conferenceObject Effects of resveratrol and caloric restriction on serum levels of norepinephrine in healthy subjects(2015) MANSUR, A. P.; ROGGERIO, A.; GOES, M. F. S.; TAKADA, J. Y.; AVAKIAN, S. D.; STRUNZ, C. M. C.conferenceObject Lack of knowledge on acute stroke in children, adolescents and adults from public schools(2021) SALLES, I. C.; GOUVEA, G. B.; CALDERARO, M.; MONTEIRO, V. S.; CORREA, R. F.; SILVA, S. N. M. F.; SHINOHARA, H. N. I.; UMEDA, I. I. K.; AIKAWA, P.; CARVALHO, H. B.; MANSUR, A. P.; CARMONA, M. J. C.; SEMERARO, F.; BOTTIGER, B. W.; NAKAGAWA, N. K.conferenceObject Effect of caloric restriction and statins on the process of cholesterol transfer to HDL in women with premature CAD(2020) LEAL, D. P.; TAVONI, T. M.; KAWABARA, K. L.; FARIA, N. F. O.; NASCIMENTO, J. R. O.; CESAR, L. A. M.; STRUNZ, C. M. C.; MANSUR, A. D. P.- Education and lifestyle measures for awareness of syncope prodroms to prevent syncope recurrence in schoolchildren(2021) MAIR, V.; SANTOS, F. R. A.; PEREIRA, H. G.; PASTORE, C. A.; SAMESIMA, N.; DINIZ, L. J.; TAKADA, J. Y.; MANSUR, A. P.; NAKAGAWA, N. K.
conferenceObject Prognosis in 10 years of follow-up of three therapeutic strategies for chronic multivessel coronary artery disease in women (study MASS)(2013) MANSUR, A. P.; HUEB, W. A.; TAKADA, J. Y.; AVAKIAN, S. D.; REZENDE, P. C.; SEGRE, A.; SOARES, P. R.; GARZILLO, C.; RAMIRES, J. A. F.; KALIL FILHO, R.conferenceObject Mortality and predictors of death in women and men with congestive heart failure with preserved, mildly reduced, and reducedejection fraction(2022) BARRETTO, A.; CARLO, C. H. Del; RAMOS NETO, J. A.; ABREU, A. B.; SCIPIONI, A. R.; MANSUR, A. P.conferenceObject Prognosis importance of absence of angina in non-ST elevation myocardial infarction(2012) TAKADA, J. Y.; RAMOS, R. B.; AVAKIAN, S. D.; RAMIRES, J. A. F.; MANSUR, A. P.Purpose: Cardiac troponins increased myocardial infarction diagnosis in patients without specific electrocardiographic changes. Absence of angina has become common and prognostic significance remains unclear. Methods: We followed 204 consecutive patients after myocardial infarction non-ST elevation(NSTEMI) at emergency department. Outcomes were in-hospital death and follow-up death or cardiac readmission. Results: No-angina (NAG) group (n = 27, 13.2%) had more women (p = 0.001), higher blood glucose (p =0.011) and B-type natriuretic factor (p < 0.001). In-hospital (14.8% vs 4.5%,p = 0.035) and 20-months follow-up mortality (43.5% vs 12.9%, p<0.001) were higher in NAG. Combination of death and cardiac read- mission was similar (70.4%vs 53.1%, p = 0.093). Age (HR = 1.038, 95% CI 1.006 to 1.071), absence of angina at admission (HR 2.554, 95% CI 1.037 to 6.289), male gender (HR 2.706, 95% CI 1.099 to 6.667) and dyspnea (HR 3.113, 95% CI 1.417 to 6.842) were independent predictors of long-term mortality. Conclusion: The absence of chest pain in NSTEMI implies in higher in-hospitaland long-term mortality.