MARCELO BATISTA BONADIO

(Fonte: Lattes)
Índice h a partir de 2011
19
Lattes
ORCID
Projetos de Pesquisa
Unidades Organizacionais
PAHC, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

Colaboração internacional: Suíça ×

Resultados de Busca

Agora exibindo 1 - 1 de 1
  • article 18 Citação(ões) na Scopus
    Comparison of Fixation Techniques of 3D-Woven Poly(epsilon-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model
    (2018) FRIEDMAN, James M.; SENNETT, Mackenzie L.; BONADIO, Marcelo B.; ORJI, Kerry O.; NEUWIRTH, Alexander L.; KEAH, Niobra; CAREY, James L.; MOUTOS, Franklin T.; ESTES, Bradley T.; GUILAK, Farshid; MADRY, Henning; MAUCK, Robert L.; DODGE, George R.
    Objective. To test different fixation methods of a 3-dimensionally woven poly(epsilon-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods. Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared including total arthrotomy (traditional) and a retinaculum-sparing, minimally invasive surgery (MIS) approach. Following microfracture (MFX), scaffolds were placed without fixation or were fixed with fibrin glue, suture, or subchondral anchor. Experimental endpoints were between 1 and 6 weeks. Micro-computed tomography and histology were used to assess samples. Results. The MIS approach was superior as the traditional approach caused medial condyle cartilage wear. One of 13 (7.7%) of scaffolds without fixation, 4 of 11 (36.3%) fibrin scaffolds, 1 of 4 (25%) of sutured scaffolds, and 9 of 9 (100%) of anchor-fixed scaffolds remained in place. Histology demonstrated tissue filling with some overgrowth of PCL scaffolds. Conclusions. Of the methods tested, the MIS approach coupled with subchondral anchor fixation provided the best scaffold retention in a mini-pig chondral defect model. This finding has implications for fixation strategies in future animal studies and potential future human use.