CAMILA PAIXAO JORDAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
10 resultados
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conferenceObject Low-intensity laser therapy on vascular reactivity and blood pressure in police officers(2020) DEMOURA, Jose Roberto; ALVES, Cleber Rene; LENOS JUNIOR, Jose Ribeiro; FONSECA, Felipe Xerez Cepeda; CORREIA, Marilia Almeida; JORDAO, Camila Paixao; DALBONI, Maria Aparecida; CHAVANTES, Maria Cristina; TROMBETTA, Ivani CredidioconferenceObject Obstructive sleep apnea impairs insulin resistance in metabolic syndrome patients with normal levels of glucose(2016) CEPEDA, Felipe Xerez; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson Cabral; TOSCHI-DIAS, Edgar; JORDAO, Camila Paixao; RONDON, Maria Urbana; ALVES, Maria Janieire N. N.; LORENZI-FILHO, Geraldo; TROMBETTA, Ivani Credidio- Arterial stiffness and its association with clustering of metabolic syndrome risk factors(2017) LOPES-VICENTE, Wanda R. P.; RODRIGUES, Sara; CEPEDA, Felipe X.; JORDAO, Camila Paixao; COSTA-HONG, Valeria; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson C.; ALVES, Maria Janieire N. N.; BORTOLOTTO, Luiz A.; TROMBETTA, Ivani C.Background: Metabolic syndrome (MetS) is associated with structural and functional vascular abnormalities, which may lead to increased arterial stiffness, more frequent cardiovascular events and higher mortality. However, the role played by clustering of risk factors and the combining pattern of MetS risk factors and their association with the arterial stiffness have yet to be fully understood. Age, hypertension and diabetes mellitus seem to be strongly associated with increased pulse wave velocity (PWV). This study aimed at determining the clustering and combining pattern of MetS risk factors and their association with the arterial stiffness in non-diabetic and non-hypertensive patients. Methods: Recently diagnosed and untreated patients with MetS (n = 64, 49 +/- 8 year, 32 +/- 4 kg/m(2)) were selected, according to ATP III criteria and compared to a control group (Control, n = 17, 49 +/- 6 year, 27 +/- 2 kg/m(2)). Arterial stiffness was evaluated by PWV in the carotid-femoral segment. Patients were categorized and analyzed according MetS risk factors clustering (3, 4 and 5 factors) and its combinations. Results: Patients with MetS had increased PWV when compared to Control (7.8 +/- 1.1 vs. 7.0 +/- 0.5 m/s, p < 0.001). In multivariate analysis, the variables that remained as predictors of PWV were age (beta = 0.450, p < 0.001), systolic blood pressure (beta = 0.211, p = 0.023) and triglycerides (beta = 0.212, p = 0.037). The increased number of risk factors reflected in a progressive increase in PWV. When adjusted to systolic blood pressure, PWV was greater in the group with 5 risk factors when compared to the group with 3 risk factors and Control (8.5 +/- 0.4 vs. 7.5 +/- 0.2, p = 0.011 and 7.2 +/- 0.3 m/s, p = 0.012). Similarly, the 4 risk factors group had higher PWV than the Control (7.9 +/- 0.2 vs. 7.2 +/- 0.3, p = 0.047). Conclusions: The number of risk factors seems to increase arterial stiffness. Notably, besides age and increased systolic blood pressure, alterations in the triglycerides worsened the stiffness of large vessels, emphasizing the importance in addressing this risk factor in MetS patients.
- Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users(2022) SOUZA, Francis Ribeiro de; SANTOS, Marcelo Rodrigues dos; ROCHITTE, Carlos Eduardo; SANTOS, Rafael Parenquine dos; JORDAO, Camila Paixao; LEITE, Ivanhoe Stuart; FONSECA, Guilherme Wesley Peixoto da; FONSECA, Rafael Almeida; OLIVEIRA, Tiago Franco de; YONAMINE, Mauricio; PEREIRA, Rosa Maria Rodrigues; NEGRAO, Carlos Eduardo; ALVES, de Nazare Nunes Maria JanieireAnabolic androgenic steroid (AAS) abuse leads to myocardial toxicity. Human studies are conflicting about the myocardial fibrosis in AAS users. We evaluated cardiac tissue characterization, left ventricle (LV) function, and cardiac structure by cardiovascular magnetic resonance (CMR). Twenty strength-trained AAS users (AASU) aged 29 +/- 5yr, 20 strength-trained AAS nonusers (AASNU), and 7 sedentary controls (SC) were enrolled. Native T1 mapping, late-gadolinium enhancement (LGE), extracellular volume (ECV), and myocardial strain were evaluated. AASU showed lower Native T1 values than AASNU (888 +/- 162 vs. 1020 +/- 179ms p=0.047). Focal myocardial fibrosis was found in 2 AASU. AASU showed lower LV radial strain (30 +/- 8 vs. 38 +/- 6%, p<0.01), LV circumferential strain (-17 +/- 3 vs. -20 +/- 2%, p<0.01), and LV global longitudinal strain (-17 +/- 3 vs. -20 +/- 3%, p<0.01) than AASNU by CMR. By echocardiography, AASU demonstrated lower 4-chamber longitudinal strain than AASNU (-15 +/- g3 vs. -18 +/- 2%, p=0.03). ECV was similar among AASU, AASNU, and SC (28 +/- 10 vs. 28 +/- 7 vs. 30 +/- 7%, p=0.93). AASU had higher LV mass index than AASNU and SC (85 +/- 14 vs. 64 +/- 8 vs. 58 +/- 5g/m(2), respectively, p<0.01). AAS abuse may be linked to decreased myocardial native T1 values, impaired myocardial contractility, and focal fibrosis. These alterations may be associated with maladaptive cardiac hypertrophy in young AAS users.
conferenceObject LOW-LEVEL LASER THERAPY REDUCED BLOOD PRESSURE RESPONSE TO MAXIMUM EXERCISE IN POLICE OFFICERS(2018) MOURA, Jose Roberto De; ALVES, Cleber Rene; LEMOS, Jose Ribeiro; JORDAO, Camila Paixao; VICENTE, Wanda Rafaela; DALBONI, Maria Aparecida; TROMBETTA, Ivani Credidio- Sacubitril/valsartan versus enalapril on exercise capacity in patients with heart failure with reduced ejection fraction: A randomized, double-blind, active-controlled study(2021) SANTOS, Marcelo Rodrigues dos; ALVES, Maria-Janieire de Nazare Nunes; JORDAO, Camila Paixao; PINTO, Caio Eduardo Novaes; CORREA, Kelly Thayane Souza; SOUZA, Francis Ribeiro de; FONSECA, Guilherme Wesley Peixoto da; TOMAZ FILHO, Joaquim; COSTA, Marcel; PEREIRA, Rosa Maria Rodrigues; NEGRAO, Carlos Eduardo; BARRETTO, Antonio Carlos PereiraBackground Sacubitril/valsar tan reduces mortality in patients with heart failure with reduced ejection fraction (HFrEF) when compared with enalapril. However, it is unknown the effect of both treatments on exercise capacity. We compared sacubitril/valsartan versus enalapril in patients with HFrEF based on peak oxygen consumption (VO2) and 6-minute walk test (6-MWT). Methods We included 52 participants with HFrEF with a left ventricular ejection fraction <40% to receive either sacu-bitril/ valsartan (target dose of 400 mg daily) or enalapril (target dose of 40 mg daily). Peak VO2 was measured by using cardiopulmonary exercise testing. Six-minute walk test was also performed. Results At 12 weeks, the sacubitril/valsartan (mean dose 382.6 +/- 57.6 mg daily) group had increased peak VO2 of 13.1% (19.35 +/- 0.99 to 21.89 +/- 1.04 mL/kg/min) and enalapril (mean dose 34.4 +/- 9.2 mg daily) 5.6% (18.58 +/- 1.19 to 19.62 +/- 1.25 mL/kg/min). However, no difference was found between groups (P = .332 interaction). At 24 weeks, peak VO2 increased 13.5% (19.35 +/- 0.99 to 21.96 +/- 0.98 mL/kg/min) and 12.0% (18.58 +/- 1.19 to 20.82 +/- 1.18 mL/kg/min) in sacubitril/valsartan (mean dose 400 +/- 0 mg daily) and enalapril (mean dose 32.7 +/- 11.0 mg daily), respectively. However, no differences were found between groups (P = .332 interaction). At 12 weeks, 6-MWT increased in both groups (sacubitril/valsartan: 459 +/- 18 to 488 +/- 17 meters [6.3%] and enalapril: 443 +/- 22 to 477 +/- 21 meters [7.7%]). At 24 weeks, sacubitril/valsartan increased 18.3% from baseline (543 +/- 26 meters) and enalapril decreased slightly to 6.8% (473 +/- 31 meters), but no differences existed between groups (P = .257 interaction). Conclusions Compared to enalapril, sacubitril/valsartan did not substantially improve peak VO2 or 6-MWT after 12 or 24 weeks in participants with HFrEF.
conferenceObject Flow-Mediated Dilation in Obese Adolescents: Correlation with Waist Circumference and Systolic Blood Pressure(2018) HUSSID, Maria Fernanda; JORDAO, Camila Paixao; LOPES-VICENTE, Wanda Rafaela; VIRMONDES, Leslie; CEPEDA, Felipe; KATAYAMA, Keyla; FRANCO-DE-OLIVEIRA, Luis Vicente; OLIVEIRA, Ezequiel F. de; COLOMBO, Fernanda Consolin; TROMBETTA, Ivani Credidio- Does Myocardial Injury Occur After an Acute Aerobic Exercise Session in Patients with Refractory Angina?(2022) MONTENEGRO, Carla Giuliano de Sa Pinto; DOURADO, Luciana Oliveira Cascaes; JORDAO, Camila Paixao; VIEIRA, Marcelo Luiz Campos; ASSUMPCAO, Camila Regina Alves; GOWDAK, Luis Henrique Wolff; PEREIRA, Alexandre da Costa; NEGRAO, Carlos Eduardo; MATOS, Luciana Diniz Nagem Janot deBackground: It is unclear whether exercise is safe in patients with more advanced forms of coronary artery disease, such as those with refractory angina (RA). Objective: We aimed to determine the effect of an acute aerobic exercise session (AAES) on high-sensitivity cardiac troponin T (hs-cTnT) levels in patients with RA. Methods: This was a longitudinal, non-randomized, and non-controlled clinical study. Participants were recruited from April 2015 to January 2019. On a visual pain scale from 0 to 10, pain rated up to 3 was considered as the top level allowed to continue exercising. We assessed hs-cTnT at baseline and 3 hours after the AAES. The protocol consisted of 5 minutes of warm-up, 30 minutes of continuous aerobic exercise at heart rate corresponding to the anaerobic threshold or angina threshold obtained in the cardiopulmonary exercise testing, and 5 minutes of cooling down. P values less than 0.05 were considered statistically significant. Results: Thirty-two patients with RA were included (61 +/- 9 years, 59.4% male). The baseline hs-cTnT concentration was 10.9 ng/L (95% confidence interval: 9.1 to 13.0 ng/L).The hs-cTnT collected 3 hours after the AAES was 11.1 ng/L (95% confidence interval: 9.1 to 13.5 ng/L). No difference occurred in hs-cTnT before and after AAES (p = 0.657). Conclusions: A single AAES performed at the angina threshold with corresponding visual pain scale did not alter hs-cTnT in patients with RA, suggesting that no significant myocardial injury was elicited by exercising and that this exercise protocol can be considered safe.
- In the Cardiac Rehabilitation Era, is There a ""No-Option"" Refractory Angina Patient?: A Case Report(2023) DOURADO, Luciana Oliveira Cascaes; JORDAO, Camila Paixao; ASSUMPCAO, Camila Regina Alves; MATOS, Luciana Diniz Nagem Janot deExercise-based cardiac rehabilitation, an effective and safe adjuvant treatment recommended to patients with coronary artery disease, is scarcely applied to patients with refractory angina (RA) due to difficulties related to safety, trainning prescription and their clinical management. This case report presents an instance of a ""no-option"" patient with RA, who was included in a 12-week exercise program, in sessions consisted of 40 minutes of treadmill aerobic exercise, three times a week, and intensity prescribed between ischemic/ angina threshold and ventilatory threshold 1, obtained in the cardiopulmonary exercise test; mild to moderate angina was allowed during training. Furthermore, 15 minutes of moderate-intensity resistance training (large group muscle exercises, two sets of 8 to 12 repetitions) was performed. At the end of the protocol, the patient presented an important improvement in functional performance (VO2 peak 17.0 ml/ kg/min to 27.3 ml/kg/min), angina threshold (HR 68 bpm to 95 bpm), and intensity chest pain (levels 7 to 5) with no clinical adverse events during the period. Exercise-based cardiac rehabilitation was safe, even in the occurrence of angina/ ischemia during training, according to tolerability to symptoms and other warning clinical signs.
conferenceObject PHOTOBIOMODULATION THERAPY REDUCED BLOOD PRESSURE RESPONSE TO MAXIMUM EXERCISE IN POLICE OFFICERS(2019) MOURA, Jose R. de; ALVES, Cleber R.; JUNIOR, Jose Ribeiro L.; JORDAO, Camila Paixao; VICENTE, Wanda; DALBONI, Maria; CHAVANTES, M. Cristina; TROMBETTA, Ivani