CAMILA PAIXAO JORDAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Exercise training preserves vagal preganglionic neurones and restores parasympathetic tonus in heart failure(2016) ICHIGE, Marcelo H. A.; SANTOS, Carla R.; JORDAO, Camila P.; CERONI, Alexandre; NEGRAO, Carlos E.; MICHELINI, Lisete C.Exercise training is an efficient tool to attenuate sympathoexcitation, a hallmark of heart failure (HF). Although sympathetic modulation in HF is widely studied, information regarding parasympathetic control is lacking. We examined the combined effects of sympathetic and vagal tonus to the heart in sedentary (Sed) and exercise trained (ET) HF rats and the contribution of respective premotor and preganglionic neurones. Wistar rats submitted to coronary artery ligation or sham surgery were assigned to training or sedentary protocols for 6weeks. After haemodynamic, autonomic tonus (atropine and atenolol i.v.) and ventricular function determinations, brains were collected for immunoreactivity assays (choline acetyltransferase, ChATir; dopamine -hydroxylase, DBHir) and neuronal counting in the dorsal motor nucleus of vagus (DMV), nucleus ambiguus (NA) and rostroventrolateral medulla (RVLM). HF-Sed vs. SHAM-Sed exhibited decreased exercise capacity, reduced ejection fraction, increased left ventricle end diastolic pressure, smaller positive and negative dP/dt, decreased intrinsic heart rate (IHR), lower parasympathetic and higher sympathetic tonus, reduced preganglionic vagal neurones and ChATir in the DMV/NA, and increased RVLM DBHir. Training increased treadmill performance, normalized autonomic tonus and IHR, restored the number of DMV and NA neurones and corrected ChATir without affecting ventricular function. There were strong positive correlations between parasympathetic tonus and ChATir in NA and DMV. RVLM DBHir was also normalized by training, but there was no change in neurone number and no correlation with sympathetic tonus. Training-induced preservation of preganglionic vagal neurones is crucial to normalize parasympathetic activity and restore autonomic balance to the heart even in the persistence of cardiac dysfunction.
conferenceObject Obstructive sleep apnea impairs insulin resistance in metabolic syndrome patients with normal levels of glucose(2016) CEPEDA, Felipe Xerez; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson Cabral; TOSCHI-DIAS, Edgar; JORDAO, Camila Paixao; RONDON, Maria Urbana; ALVES, Maria Janieire N. N.; LORENZI-FILHO, Geraldo; TROMBETTA, Ivani CredidiobookPart Ergoespirometria(2016) AGOSTINHO, Daniela Regina; JORDãO, Camila Paixão; NEGRãO, Carlos EduardoconferenceObject Ventricular disfunction induces morphofunctional changes in adrenal glands(2016) ANDRADE, Thulio Ramos de; SILVA, Juliane; SOUZA, Leandro; JORDAO, Camila; FERRELRA, Tatiane; NEGRAO, Carlos; BRUM, Patricia; IRIGOYEN, Maria Claudia; LACCHINI, Silvia; ALVES, Maria JanieireconferenceObject Clustering and combining pattern of metabolic syndrome risk factors and its association with arterial stiffness(2016) VICENTE, Wanda Rafaela; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson C.; JORDAO, Camila P.; TOSCHI-DIAS, Edgar; HUSSID, Maria Fernanda; COSTA-HONG, Valeria; BORTOLOTTO, Luiz A.; CEPEDA, Felipe X.; TROMBETTA, Ivani Credidio