CAMILA PAIXAO JORDAO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
29 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 29
- Exercise training preserves vagal preganglionic neurones and restores parasympathetic tonus in heart failure(2016) ICHIGE, Marcelo H. A.; SANTOS, Carla R.; JORDAO, Camila P.; CERONI, Alexandre; NEGRAO, Carlos E.; MICHELINI, Lisete C.Exercise training is an efficient tool to attenuate sympathoexcitation, a hallmark of heart failure (HF). Although sympathetic modulation in HF is widely studied, information regarding parasympathetic control is lacking. We examined the combined effects of sympathetic and vagal tonus to the heart in sedentary (Sed) and exercise trained (ET) HF rats and the contribution of respective premotor and preganglionic neurones. Wistar rats submitted to coronary artery ligation or sham surgery were assigned to training or sedentary protocols for 6weeks. After haemodynamic, autonomic tonus (atropine and atenolol i.v.) and ventricular function determinations, brains were collected for immunoreactivity assays (choline acetyltransferase, ChATir; dopamine -hydroxylase, DBHir) and neuronal counting in the dorsal motor nucleus of vagus (DMV), nucleus ambiguus (NA) and rostroventrolateral medulla (RVLM). HF-Sed vs. SHAM-Sed exhibited decreased exercise capacity, reduced ejection fraction, increased left ventricle end diastolic pressure, smaller positive and negative dP/dt, decreased intrinsic heart rate (IHR), lower parasympathetic and higher sympathetic tonus, reduced preganglionic vagal neurones and ChATir in the DMV/NA, and increased RVLM DBHir. Training increased treadmill performance, normalized autonomic tonus and IHR, restored the number of DMV and NA neurones and corrected ChATir without affecting ventricular function. There were strong positive correlations between parasympathetic tonus and ChATir in NA and DMV. RVLM DBHir was also normalized by training, but there was no change in neurone number and no correlation with sympathetic tonus. Training-induced preservation of preganglionic vagal neurones is crucial to normalize parasympathetic activity and restore autonomic balance to the heart even in the persistence of cardiac dysfunction.
conferenceObject Low-intensity laser therapy on vascular reactivity and blood pressure in police officers(2020) DEMOURA, Jose Roberto; ALVES, Cleber Rene; LENOS JUNIOR, Jose Ribeiro; FONSECA, Felipe Xerez Cepeda; CORREIA, Marilia Almeida; JORDAO, Camila Paixao; DALBONI, Maria Aparecida; CHAVANTES, Maria Cristina; TROMBETTA, Ivani CredidioconferenceObject Cardiac rehabilitation in patients with refractory angina: preliminary results(2019) DOURADO, L.; ASSUMPCAO, C. R. A. A.; JORDAO, C. P.; VIEIRA, M. L. C.; GOWDAK, L. H. W.; CESAR, L. A. M.; MATOS, L. D. N. J.- Cardiopulmonary exercise test in patients with refractory angina: functional and ischemic evaluation(2022) ASSUMPCAO, Camila R. A. de; PRADO, Danilo M. L. do; JORDAO, Camila P.; DOURADO, Luciana O. C.; VIEIRA, Marcelo L. C.; MONTENEGRO, Carla G. de S. P.; NEGRAO, Carlos E.; GOWDAK, Luis H. W.; MATOS, Luciana D. N. J. DeObjectives: Refractory angina (RA) is a chronic condition clinically characterized by low effort tolerance; therefore, physical stress testing is not usually requested for these patients. Cardiopulmonary exercise testing (CPET) is con-sidered a gold standard examination for functional capacity evaluation, even in submaximal tests, and it has gained great prominence in detecting ischemia. The authors aimed to determine cardiorespiratory capacity by using the oxygen consumption efficiency slope (OUES) in patients with refractory angina. The authors also stud-ied the O-2 pulse response by CPET and the association of ischemic changes with contractile modifications by exer-cise stress echocardiography (ESE). Methods: Thirty-one patients of both sexes, aged 45 to 75 years, with symptomatic (Canadian Cardiovascular Soci-ety class II to IV) angina who underwent CPET on a treadmill and exercise stress echocardiography on a lower limb cycle ergometer were studied. ClinicalTrials.gov: NCT03218891. Results: The patients had low cardiorespiratory capacity (OUES of 1.74 +/- 0.4 L/min; 63.9 +/- 14.7% of predicted), and 77% of patients had a flattening or drop in O-2 pulse response. There was a direct association between Heart Rate (HR) at the onset of myocardial ischemia detected by ESE and HR at the onset of flattening or drop in oxygen pulse response detected by CPET (R = 0.48; p = 0.019). Conclusion: Patients with refractory angina demonstrate low cardiorespiratory capacity. CPET shows good sensi-tivity for detecting abnormal cardiovascular response in these patients with a significant relationship between flattening O-2 pulse response during CEPT and contractile alterations detected by exercise stress echocardiography.
conferenceObject Swimming training improves arterial vasomotor function in spontaneously hypertensive rats: role of reactive oxygen species and nitrogen(2014) JORDAO, C. P.; FERNANDES, T.; TANAKA, L.; OLIVEIRA, L. G.; BECHARA, L. G.; OLIVIERA, E. M.; RAMIRES, P. R.conferenceObject Early findings in patients with noncompaction cardiomyopathy and normal ejection fraction: a cardiopulmonary exercise test, echocardiographic and biomarkers study(2019) AOKI, A. F.; SANTOS, M. R. Dos; ANDRETTA, C. R. L.; YEU, S. P.; MELO, M. D. Tavares De; JORDAO, C. P.; GUIMARAES, G. V.; STRUNZ, C. M. C.; BOCCHI, E. A.; SALEMI, V. M. C.conferenceObject Obstructive sleep apnea impairs insulin resistance in metabolic syndrome patients with normal levels of glucose(2016) CEPEDA, Felipe Xerez; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson Cabral; TOSCHI-DIAS, Edgar; JORDAO, Camila Paixao; RONDON, Maria Urbana; ALVES, Maria Janieire N. N.; LORENZI-FILHO, Geraldo; TROMBETTA, Ivani Credidio- Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users(2022) SOUZA, Francis Ribeiro de; SANTOS, Marcelo Rodrigues dos; ROCHITTE, Carlos Eduardo; SANTOS, Rafael Parenquine dos; JORDAO, Camila Paixao; LEITE, Ivanhoe Stuart; FONSECA, Guilherme Wesley Peixoto da; FONSECA, Rafael Almeida; OLIVEIRA, Tiago Franco de; YONAMINE, Mauricio; PEREIRA, Rosa Maria Rodrigues; NEGRAO, Carlos Eduardo; ALVES, de Nazare Nunes Maria JanieireAnabolic androgenic steroid (AAS) abuse leads to myocardial toxicity. Human studies are conflicting about the myocardial fibrosis in AAS users. We evaluated cardiac tissue characterization, left ventricle (LV) function, and cardiac structure by cardiovascular magnetic resonance (CMR). Twenty strength-trained AAS users (AASU) aged 29 +/- 5yr, 20 strength-trained AAS nonusers (AASNU), and 7 sedentary controls (SC) were enrolled. Native T1 mapping, late-gadolinium enhancement (LGE), extracellular volume (ECV), and myocardial strain were evaluated. AASU showed lower Native T1 values than AASNU (888 +/- 162 vs. 1020 +/- 179ms p=0.047). Focal myocardial fibrosis was found in 2 AASU. AASU showed lower LV radial strain (30 +/- 8 vs. 38 +/- 6%, p<0.01), LV circumferential strain (-17 +/- 3 vs. -20 +/- 2%, p<0.01), and LV global longitudinal strain (-17 +/- 3 vs. -20 +/- 3%, p<0.01) than AASNU by CMR. By echocardiography, AASU demonstrated lower 4-chamber longitudinal strain than AASNU (-15 +/- g3 vs. -18 +/- 2%, p=0.03). ECV was similar among AASU, AASNU, and SC (28 +/- 10 vs. 28 +/- 7 vs. 30 +/- 7%, p=0.93). AASU had higher LV mass index than AASNU and SC (85 +/- 14 vs. 64 +/- 8 vs. 58 +/- 5g/m(2), respectively, p<0.01). AAS abuse may be linked to decreased myocardial native T1 values, impaired myocardial contractility, and focal fibrosis. These alterations may be associated with maladaptive cardiac hypertrophy in young AAS users.
- Sympathetic Neural Overdrive, Aortic Stiffening, Endothelial Dysfunction, and Impaired Exercise Capacity in Severe COVID-19 Survivors: A Mid-Term Study of Cardiovascular Sequelae(2023) FARIA, Diego; MOLL-BERNARDES, Renata J.; TESTA, Laura; MONIZ, Camila M. V.; RODRIGUES, Erika C.; RODRIGUES, Amanda G.; ARAUJO, Amanda; ALVES, Maria J. N. N.; ONO, Bruna E.; IZAIAS, Joao E.; SALEMI, Vera M. C.; JORDAO, Camila P.; AMARO-VICENTE, Graziela; RONDON, Maria U. P. B.; LUDWIG, Katelyn R.; CRAIGHEAD, Daniel H.; ROSSMAN, Matthew J.; CONSOLIM-COLOMBO, Fernanda M.; ANGELIS, Katia De; IRIGOYEN, Maria C. C.; SEALS, Douglas R.; NEGRAO, Carlos E.; SALES, Allan R. K.Background:COVID-19 has become a dramatic health problem during this century. In addition to high mortality rate, COVID-19 survivors are at increased risk for cardiovascular diseases 1-year after infection. Explanations for these manifestations are still unclear but can involve a constellation of biological alterations. We hypothesized that COVID-19 survivors compared with controls exhibit sympathetic overdrive, vascular dysfunction, cardiac morpho-functional changes, impaired exercise capacity, and increased oxidative stress. Methods:Nineteen severe COVID-19 survivors and 19 well-matched controls completed the study. Muscle sympathetic nerve activity (microneurography), brachial artery flow-mediated dilation and blood flow (Doppler-Ultrasound), carotid-femoral pulse wave velocity (Complior), cardiac morpho-functional parameters (echocardiography), peak oxygen uptake (cardiopulmonary exercise testing), and oxidative stress were measured similar to 3 months after hospital discharge. Complementary experiments were conducted on human umbilical vein endothelial cells cultured with plasma samples from subjects. Results:Muscle sympathetic nerve activity and carotid-femoral pulse wave velocity were greater and brachial artery flow-mediated dilation, brachial artery blood flow, E/e ' ratio, and peak oxygen uptake were lower in COVID-19 survivors than in controls. COVID-19 survivors had lower circulating antioxidant markers compared with controls, but there were no differences in plasma-treated human umbilical vein endothelial cells nitric oxide production and reactive oxygen species bioactivity. Diminished peak oxygen uptake was associated with sympathetic overdrive, vascular dysfunction, and reduced diastolic function in COVID-19 survivors. Conclusions:Our study revealed that COVID-19 survivors have sympathetic overactivation, vascular dysfunction, cardiac morpho-functional changes, and reduced exercise capacity. These findings indicate the need for further investigation to determine whether these manifestations are persistent longer-term and their impact on the cardiovascular health of COVID-19 survivors.
- Exercise Training on Anginal Threshold Does Not Improve Endothelial Function in Refractory Angina Patients(2023) JORDA, Camila P.; DOURADO, Luciana O. C.; ASSUMPCAO, Camila R. A. de; VIEIRA, Marcelo L. C.; MONTENEGRO, Carla G. De S. P.; NEGRAO, Carlos E.; MATOS, Luciana D. N. J. DeRefractory angina (RA) is a chronic condition of coronary artery disease (CAD). Endothelial function (EF) measured by flow-mediated dilation (FMD) is an important prognostic marker in CAD. Exercise training is a stimulus that improves EF in CAD. However, exercise training effects on EF in RA are unknown. Therefore, we aimed to verify the effects of exercise training on EF in RA. This was a longitudinal, non-randomized clinical study, involving patients with patients limited by angina, aged 45 to 75 years. Patients were prospectively allocated by convenience to either exercise trained (ET) or control group (C). Laboratory analysis, cardiopulmonary exercise test (CPET), and FMD were implemented at inclusion and after 12 weeks of exercise training or clinical treatment period. Exercise training included 60 minutes per session, 3 times a week, including 40 minutes of aerobic exercise on anginal threshold heart rate obtained on the CPET, 15 minutes of resistance training, and 5 minutes of stretching. A total of 38 patients were included (mean age 60 9 years, 22 men); 21 were allocated to the ET and 17 to the C group. Baseline measures showed no differences between groups. After 12 weeks glycated hemoglobin and systolic blood pressure were lower in ET before than ET after (p = 0.004, and p = 0.05, respectively), and exercise time of the CPET was lower in ET before than ET after (p = 0.002). Exercise training did not change FMD. In conclusion, exercise training performed on anginal threshold increases exercise tolerance but causes no changes in EF in patients with RA. & COPY; 2023 Published by Elsevier Inc. (Am J Cardiol 2023;204:352 -359)
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