SEISSE GABRIELA GANDOLFI SANCHES
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, Faculdade de Medicina
LIM/34 - Laboratório de Ciências da Reabilitação, Hospital das Clínicas, Faculdade de Medicina
LIM/34 - Laboratório de Ciências da Reabilitação, Hospital das Clínicas, Faculdade de Medicina
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- Mercury Exposure in a Riverside Amazon Population, Brazil: A Study of the Ototoxicity of Methylmercury(2015) HOSHINO, Ana; PACHECO-FERREIRA, Heloisa; SANCHES, Seisse Gabriela G.; CARVALLO, Renata; CARDOSO, Nathália; PEREZ, Maurício; CÂMARA, Volney de MagalhãesIntroduction Mercury poisoning causes hearing loss in humans and animals. Acute and long-term exposures produce irreversible peripheral and central auditory system damage, and mercury in its various forms of presentation in the environment is ototoxic. Objective We investigated the otoacoustic emissions responses in a riverside population exposed to environmental mercury by analyzing the inhibitory effect of the medial olivocochlear system (MOCS) on transient otoacoustic emissions (TEOAE). Methods The purpose of the research was to evaluate the entire community independently of variables of sex and age. All of the participants were born and lived in a riverside community. After otolaryngologic evaluation, participants were received tympanometry, evaluation of contralateral acoustic reflexes, pure tone audiometry, and recording of TEOAEs with nonlinear click stimulation. Hair samples were collect to measure mercury levels. Results There was no significant correlation between the inhibitory effect of the MOCS, age, and the level of mercury in the hair. Conclusions The pathophysiological effects of chronic exposure may be subtle and nonspecific and can have a long period of latency; therefore, it will be important to monitor the effects of mercury exposure in the central auditory system of the Amazon population over time. Longitudinal studies should be performed to determine whether the inhibitory effect of the MOCS on otoacoustic emissions can be an evaluation method and diagnostic tool in populations exposed to mercury.
- Ressonância da orelha média em lactentes: efeito da idade(2012) ANDRÉ, Karina Delgado; SANCHES, Seisse Gabriela Gandolfi; CARVALLO, Renata Mota MamedeINTRODUCTION: The resonant frequency is the probe frequency in which susceptance is 0 due to the neutralization of the forces of mass and stiffness components that control the middle ear. This frequency can be evaluated by multifrequency tympanometry, and the normality value for adults ranges 800-1,200 Hz. Studies about resonant frequency in children are scarce. AIM: Identify the variation of the resonant frequency in infants between the first days after birth and the third month of life. METHOD: Prospective study. Thirty newborns were evaluated at 2 different times: at the neonatal phase up to 12 days of life, and between 72 and 84 days of life. In the first evaluation, we carried out otoacoustic emissions and identified the resonant frequency, and identified the resonant frequency again in the second evaluation. RESULTS: In the first evaluation, we determined a mean resonance value of 250 Hz for both ears, while that in the second evaluation was 385 Hz. In both assessments, we found no significant differences between the ears. There was a significant difference between the first and second evaluation. CONCLUSION: The middle ear resonant frequency in infants is lower in the first days of life due to the influence of the mass component. The present study demonstrated that the resonance frequency increased in the first months of life.