LUCAS MELO NEVES
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Physical exercise for bipolar disorder: Time for action COMMENT(2022) LAFER, Beny; NEVES, Lucas Melo; NIERENBERG, Andrew A.
conferenceObject The impact of structured physical exercise on cognitive function of bipolar patients: A study protocol for a randomized controlled trial(2023) BELIZARIO, Gabriel; DUARTE, Cicera; NEVES, Lucas; MATHIAS, Karla; LAFER, Beny- Medical Students Show Lower Physical Activity Levels and Higher Anxiety Than Physical Education Students: A Cross-Sectional Study During the COVID-19 Pandemic(2021) SOUZA, Karla Cardoso de; MENDES, Tassia Barcelos; GOMES, Tabatah Hellen Santos; SILVA, Ariana Aline da; NALI, Luiz Henrique da Silva; BACHI, Andre Luis Lacerda; ROSSI, Fabricio Eduardo; GIL, Saulo; FRANCA, Carolina Nunes; NEVES, Lucas MeloObjective: This study aimed to compare the time in physical activity (PA) [light (LPA), moderate and vigorous (MVPA)] and sedentary behavior (SB) (weekdays, weekends, or both) between Medical (MED) and Physical Education (PE) students who underwent remote classes imposed by the COVID-19. In addition, we compared symptoms of depression and anxiety and sleep quality.Methods: A cross-sectional study (272 MED and 95 PE students). The International Physical Activity Questionnaire (IPAQ), Beck Inventory (Anxiety, Depression), and Pittsburgh Sleep Quality were used to assess PA and SB, anxiety and depression symptoms, and quality of sleep, respectively. The data are presented as median and interquartile intervals 25-75.Results: We observed statistically significant differences between MED and PE students for MVPA [MED: 165 min per week (0-360) vs. PE: 420 min per week (180-670), p < 0.001], SB Total [MED: 10 h per day (8-12) vs. PE: 7 h per day (5-10), p < 0.001)], and anxiety symptoms [MED: 13 points (5-23) vs. PE: six points (2-16), p < 0.001)].Conclusion: Together, our findings indicate that MED students spent less time in MVPA and more time in SB than PE students. MED students also presented worse mental health in the pandemic situation imposed by the COVID-19.
- Structured physical exercise for bipolar depression: an open-label, proof-of concept study(2023) LAFER, Beny; DUARTE, Cicera Claudinea; GREVE, Julia Maria D'Andrea; SILVA, Paulo Roberto dos Santos; ALMEIDA, Karla Mathias de; BELIZARIO, Gabriel Okawa; NEVES, Lucas MeloBackgroundPhysical exercise (PE) is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder. Considering the similar symptomatology of the depressive phase in patients with bipolar disorder (BD) and unipolar depressive disorder, it is reasonable to suggest that PE may also be beneficial for bipolar depression. However, there is an absence of studies evaluating the antidepressant effect of a structured PE intervention in BD.MethodsThis is an open-label, single-arm study trial. Fifteen patients with a diagnosis of BD Type I or Type II, presenting a depressive episode were included in the study. After physical and functional evaluation, patients participated in supervised training sessions with aerobics followed by strength exercises, three times per week, for 12 weeks (36 training sessions). Depressive and manic symptoms were assessed at baseline and 2, 4, 8, and 12 weeks. Additionally, quality of Life and functioning were assessed at baseline and 4, 8, and 12 weeks). Finally, we tested cardiorespiratory fitness, muscle strength and body composition at baseline and week-12.ResultsThe mean (+/- SD) Montgomery Asberg Depression Rating Scale (MADRS) score at baseline was 23.6 +/- 8.3 points and after 12 weeks of PE the mean score was 10.2 +/- 4.8 points. Nine patients (82%) presented an antidepressant response defined as a reduction of more than 50% of depressive symptoms at week 12 with five of those patients (45%) presenting criteria for full remission. A large and significant Cohen's D Effect Size (pre-post) was verified for MADRS reduction [1.98 (95% Confidence interval = 0.88 to 3.08)]. We did not detect a significant change in manic symptoms, functioning, and quality of life during the 12-week follow-up. At week-12, all patients increased their muscular strength (one repetition maximal test - 1RM) and reduced the percentage of body fat (spectral bioelectrical impedance analysis).ConclusionsThis study, using rigorous criteria and a structured intervention, provides valid pilot data, showing the feasibility of a structured PE intervention for the treatment of depressive symptoms in BD, and suggesting a potential adjunctive antidepressant effect. Moreover, PE showed a positive impact on muscle strength and body composition. This should be further verified by randomized controlled studies.
conferenceObject Diet, nutrition, and eating behaviors in bipolar disorder: A narrative review from the ISBD nutrition and exercise task force (NEXT)(2023) BRIETZKE, Elisa; KONING, Elena; ALSUWAIDAN, Mohammad; BALANZA-MARTINEZ, Vicent; BERK, Michael; FIEDOROWICZ, Jess; FRYE, Mark; GARDEA-RESENDEZ, Manuel; GOMES, Fabiano; GONZALEZ-PINTO, Ana; MANSUR, Rodrigo; MARX, Wolfgang; MILEV, Roumen; NEVES, Lucas; NIERENBERG, Andrew; OLAGUNJU, Andrew; SARAF, Gayatri; SOLMI, Marco; LAFER, Beny- Clinical and neuroimaging correlates in a pilot randomized trial of aerobic exercise for major depression(2024) MOREIRA-NETO, Acacio; NEVES, Lucas Melo; MILIATTO, Angelo; JUDAY, Valeria; MARQUESINI, Raquel; LAFER, Beny; CARDOSO, Ellison Fernando; UGRINOWITSCH, Carlos; NUCCI, Mariana Penteado; SILVA-BATISTA, CarlaBackground: Aerobic exercise (AE) combined with pharmacotherapy is known to reduce depressive symptoms; however, studies have not focused on long-term AE for volumetric changes of brain regions (amygdala, thalamus, and nucleus accumbens [NAcc]) linked to the control of affective responses and hopelessness in individuals with major depression (MD). In addition, AE with motor complexity (AEMC) would be more effective than AE in causing brain plasticity. We compared the effects of 24 weeks of AE and AEMC combined with pharmacotherapy on clinical and volumetric outcomes in individuals with MD.Methods: Forty medicated individuals with MD were randomly assigned to nonexercising control (C), AE, and AEMC groups. The training groups exercised for 60 min, twice a week for 24 weeks. Clinical and volumetric outcomes were assessed before and after the 24 weeks. Effect size (ES) and confidence interval (CI) were calculated for within-group and between-groups changes.Results: AE and AEMC reduced hopelessness (ES =-0.73 and ES =-0.62, respectively) and increased affective responses (ES = 1.24 and ES = 1.56, respectively). Only AE increased amygdala (ES = 0.27 left and ES = 0.34 right), thalamus (ES = 0.33 left and ES = 0.26 right) and left NAcc (ES = 0.54) volumes. AE was more effective than the C group in reducing hopelessness and causing brain plasticity. The changes in the right amygdala volume showed a strong trend in explaining 72 % of the changes in affective responses following AE (p = 0.06). Limitation: Lack of posttraining follow-up and small sample size.Conclusion: These preliminary data indicate that AE combined with pharmacotherapy can cause clinical improvement and brain plasticity in individuals with MD.