ANGELITA HABR GAMA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Gastroenterologia, Faculdade de Medicina - Docente
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
bookPart Tratamento da deiscência anastomótica colorretal(2017) JULIãO, Guilherme Pagin São; VAILATI, Bruna Borba; PEREZ, Rodrigo Oliva; HABR-GAMA, AngelitabookPart Angelita Habr-Gama - vida no tempo presente(2020) HABR-GAMA, Angelita- Selective non-operative management of distal rectal cancer: The Watch & Wait Protocol(2012) HABR-GAMA, A.; PEREZ, R. O.; LYNN, P. B.; JULIãO, G. P. São; RODRIGUES, J. J. GamaThe observation of improved local disease control with the use of preoperative chemoradiation (CRT) for locally advanced rectal cancer established this treatment strategy as one the preferred initial approaches for this disease. Interestingly, the benefits of preoperative CRT were not restricted to local recurrence rates but also included reduced toxicity rates compared to postoperative CRT, significant tumor downstaging and downsizing, greater rates of sphincter preservation, and better functional results [1, 2]. © 2012 Springer-Verlag/Wien. All rights reserved.
bookPart Avanço de Retalho Cutâneo/Mucoso na Fissura Anal. Aspectos Técnicos e Critérios para Indicação(2013) JACOB, Carlos Eduardo; HABR-GAMA, Angelita; LYNN, Patrício; GAMA-RODRIGUES, Joaquim- Role of radiation in rectal cancers(2015) HABR-GAMA, A.; JORGE, J. M. N.; BUSTAMANTE-LOPEZ, L. A.The management of rectal cancer has dramatically improved during the last two decades and therapeutic decisions should now be individualized and based on a multidisciplinary approach, involving radiation oncologists, medical oncologists, diagnostic radiologists, surgeons, pathologists, and primary care physicians. The benefits of preoperative chemoradiotherapy include downsizing, downstaging, improved sphincter-preservation rates, and reduced local recurrence. In addition, complete pathological response is possible in a significant percentage of patients. The combination of neoadjuvant radiotherapy and total mesorectal excision may result in significant long-term adverse effects, including sexual and anorectal sphincter dysfunction. This should be taken into account during selection of patients for radiotherapy. In addition, ongoing trials are addressing quality of life issues with modern radiation techniques and newer chemotherapeutic agents. © Springer Science+Business Media, LLC 2015.
- Local excision of rectal cancer(2015) HABR-GAMA, A.; FIGUEIREDO, M. N.; JULIãO, G. P. São; PEREZ, R. O.Transanal Local Excision has become a very useful surgical tool for the management of selected cases of rectal cancer due to its low postoperative morbidity and minimal functional consequences. However, the considerably high local recurrence rates led to the introduction of preoperative therapies. Neoadjuvant chemoradiation therapy has been considered the preferred alternative in this setting and may result in significant rates of tumor regression allowing the procedure to be offered to a significant proportion of cases. On the other hand, this multimodality approach may also determine increased postoperative morbidity. In addition, completion or salvage total mesorectal excision in the case of local recurrence or the presence of unfavorable pathological features may also be a challenging task. Finally, accurate selection criteria for this minimally invasive approach are still lacking and may be influenced by baseline staging, post-treatment staging and final pathology information. Ultimately, selection of patients for this treatment modality remains a significant challenge for colorectal surgeons. In the present chapter, the rationale, surgical technique and outcomes of transanal local excision are detailed both after surgery alone or in the setting of multimodality therapy. © Springer-Verlag London 2015.
- The approach to the rectal cancer patient with a suspected complete clinical response: Selection of patients to the watch and wait strategy(2014) PEREZ, R. O.; HABR-GAMA, A.
- Effects of radiation therapy for rectal cancer on anorectal function(2015) JORGE, J. M. N.; HABR-GAMA, A.; BUSTAMANTE-LOPEZ, L. A.Regardless of whether adjuvant or neoadjuvant radiotherapy is used, pelvic irradiation adversely affects anorectal function. Although survival remains the primary goal in treatment, maintaining adequate anal continence is necessary for good quality of life. Radiation damages to the internal anal sphincter and the myenteric cells are frequently seen. Other mechanisms of continence affected by radiotherapy include decreased stool consistency, impaired rectal capacity, and decreased anorectal sensation. These adverse effects are associated with an increasing indication of sphincter-preserving operations, and demand for improved radiation techniques and more favorable postoperative functional results. Symptoms of urgency and fecal incontinence are common after anterior resection with or without neoadjuvant chemoradiotherapy, but generally resolve within the first 2 years after surgery. In patients with persistent symptoms of fecal incontinence, conservative therapy including biofeedback should be offered. © Springer Science+Business Media, LLC 2015.
- The proper treatment for the complete responder after neoadjuvant therapy(2018) HABR-GAMA, A.; BRUZZI, M. S.; MORICI, M. L.; JULIãO, G. P. São; PEREZ, R. O.The incorporation of new treatment modalities has significantly increased the complexity of decision-making for patients with locally advanced rectal cancer. Neoadjuvant chemoradiation (CRT) is considered one of the preferred treatment strategies for these patients. In addition, this treatment strategy may lead to significant tumor regression, ultimately leading to complete pathological response in up to 42% of patients. The assessment of tumor response following CRT and prior to radical surgery may identify patients with complete clinical response that could be managed nonoperatively with strict follow-up (watch and wait strategy) and thus avoiding unnecessary postoperative morbidity, including long-term urinary, sexual, and fecal continence dysfunctions and the frequent need for temporary or definitive stomas. Avoiding immediate surgery for patients with complete clinical response may provide good long-term oncological outcomes and excellent functional results. In addition, close surveillance may allow early detection of local recurrences with salvage options avoiding any oncological compromise. This chapter deals with critical issues in appropriate selection of patients, details in follow-up, and management of local recurrences following a nonoperative approach to a patient with complete clinical response following neoadjuvant CRT. © Springer Japan 2018.
bookPart 1 Citação(ões) na Scopus Rectal prolapse: Perineal approach(2012) HABR-GAMA, A.; JACOB, C. E.; PEREZ, R. O.; PROSCURSHIM, I.