WERTHER BRUNOW DE CARVALHO

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Departamento de Pediatria, Faculdade de Medicina - Docente
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina - Líder

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Agora exibindo 1 - 10 de 26
  • article 2 Citação(ões) na Scopus
    Nutritional Assessment and Body Composition in Critically Ill Children as Prognostic Indicators
    (2019) ZAMBERLAN, P.; CARVALHO, W.B. de; DELGADO, A.F.
    Purpose of review: Malnutrition is very common in critically ill patients, mainly children and adolescents, and it increases morbidity, length of stay, medical costs, and mortality. Anthropometric and body composition assessment are basic components for monitoring nutritional status. In addition, it appears to be able to predict several clinical outcomes in these patients. This review describes studies evaluating usefulness of nutritional and prognostic assessment tools in critically ill patients. Recent findings: Although anthropometry is difficult to interpret in critically ill patients, it is very useful for classifying nutrition status, as well as for planning nutritional therapy (NT) and nutrition monitoring. Several traditional nutritional markers (zinc, selenium, prealbumin, and HDL) have been used as inflammatory and, consequently, prognostic indicators. Body composition indicators as phase angle obtained by bioelectrical impedance and arm circumference have shown a strong ability to predict outcomes in a wide variety of clinical situations, including critically ill children and adolescents. Summary: Early intervention targeting nutrition assessment can prevent or minimize the complications of undernutrition in the intensive care unit. Thus, improving the accuracy of nutritional and prognostic evaluation is of paramount importance in the clinical management of critically ill patients. © 2019, Springer Nature Switzerland AG.
  • article 13 Citação(ões) na Scopus
    Current management of occult bacteremia in infants
    (2015) MEKITARIAN FILHO, Eduardo; CARVALHO, Werther Brunow de
    Objectives: To summarize the main clinical entities associated with fever without source (FWS) in infants, as well as the clinical management of children with occult bacteremia, emphasizing laboratory tests and empirical antibiotics. Sources: A non-systematic review was conducted in the following databases - PubMed, EMBASE, and SciELO, between 2006 and 2015. Summary of the findings: The prevalence of occult bacteremia has been decreasing dramatically in the past few years, due to conjugated vaccination against Streptococcus pneumoniae and Neisseria meningitidis. Additionally, fewer requests for complete blood count and blood cultures have been made for children older than 3 months presenting with FWS. Urinary tract infection is the most prevalent bacterial infection in children with FWS. Some known algorithms, such as Boston and Rochester, can guide the initial risk stratification for occult bacteremia in febrile infants younger than 3 months. Conclusions: There is no single algorithm to estimate the risk of occult bacteremia in febrile infants, but pediatricians should strongly consider outpatient management in fully vaccinated infants older than 3 months with FWS and good general status. Updated data about the incidence of occult bacteremia in this environment after conjugated vaccination are needed.
  • article 2 Citação(ões) na Scopus
    Neonatal Hypotension: What Is the Efficacy of Each Anti-Hypotensive Intervention? A Systematic Review
    (2019) MATSUSHITA, F.Y.; KREBS, V.L.J.; CARVALHO, W.B. de
    Purpose of review: There is no consensus in the treatment of hemodynamic instability in the preterm newborn. Blood pressure is one of the few measurable objective parameters for hemodynamic evaluation in this population. However, little is known about the efficacy of anti-hypotensive treatments in newborns. The objective of this review is to identify and analyze the efficacy of a given anti-hypotensive intervention in improving the hypotensive preterm newborn. Recent findings: With the increase in survival of the preterm newborns, there was an augmentation in the interest for the treatment of hypotension in this population. However, as there are doubts regarding the efficacy in anti-hypotensive treatment, new drugs are being used to reverse the hypotensive state in preterm infants: epinephrine, norepinephrine, vasopressin, and steroids. Summary: We have identified that classically used medications in the treatment of hypotension have little evidence of efficacy in rescuing the preterm infant from the hypotensive state. New therapies are emerging with potential benefits, especially in refractory hypotension such as epinephrine and norepinephrine, but more prospective studies are needed. Literature review should be careful, considering the definition used for hypotension, the time of onset, the intravascular volume status of each patient, and if the drug was used as a first or second line of treatment. © 2019, Springer Nature Switzerland AG.
  • article 3 Citação(ões) na Scopus
    Beyond ventilatory support: challenges in general practice and in the treatment of critically Ill children and adolescents with SARS-CoV-2 infection
    (2020) FERRANTI, Juliana Ferreira; RODRIGUEZ, Isadora Souza; MOTT, Emiliana; JOHNSTON, Cintia; CARVALHO, Werther Brunow de B.; DELGADO, Artur Figueiredo
    Severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2 infection) is a new challenge for all countries, and children are predisposed to acquire this disease. Some studies have demonstrated more severe diseases in adults, but critically ill pediatric patients have been described in all ages. Pulmonary involvement is the major feature, and ventilatory support is common in critical cases. Nevertheless, other very important therapeutic approaches must be considered. In this article, we reviewed extensively all recent medical literature to point out the main clinical attitudes to support these pediatric patients during their period in respiratory support. Radiologic findings, fluid therapy, hemodynamic support, use of inotropic/vasopressors, nutritional therapy, antiviral therapy, corticosteroids, antithrombotic therapy, and immunoglobulins are analyzed to guide all professionals during hospitalization. We emphasize the importance of a multi-professional approach for adequate recovery.
  • article 4 Citação(ões) na Scopus
    Ventilatory support recommendations in children with Sars-CoV-2
    (2020) CARVALHO, Werther Brunow de; RODRIGUEZ, Isadora Souza; MOTTO, Emiliana Holzhausen Goncolves da; DELGADO, Artur Figueiredo
  • article 14 Citação(ões) na Scopus
    Expert recommendations for the care of newborns of mothers with COVID-19
    (2020) CARVALHO, Werther Brunow de; GIBELLI, Maria Augusta Bento Ciceroni; KREBS, Vera Lucia Jornada; CALIL, Valdenise Martins Laurindo Tuma; JOHNSTON, Cintia
    This article presents expert recommendations for assisting newborn children of mothers with suspected or diagnosed coronavirus disease 2019 (COVID-19). The consensus was developed by five experts with an average of 20 years of experience in neonatal intensive care working at a reference university hospital in Brazil for the care of pregnant women and newborns with suspected or confirmed COVID-19. Despite the lack of scientific evidence regarding the potential for viral transmission to their fetus in pregnant mothers diagnosed with or suspected of COVID-19, it is important to elaborate the lines of care by specialists from hospitals caring for suspected and confirmed COVID-19 cases to guide multidisciplinary teams and families diagnosed with the disease or involved in the care of pregnant women and newborns in this context. Multidisciplinary teams must be attentive to the signs and symptoms of COVID-19 so that decision-making is oriented and assertive for the management of the mother and newborn in both the hospital setting and at hospital discharge.
  • article 11 Citação(ões) na Scopus
    COVID-19 and Liver Damage: Narrative Review and Proposed Clinical Protocol for Critically ill Pediatric Patients
    (2020) LUGLIO, Michele; TANNURI, Uenis; CARVALHO, Werther Brunow de; BASTOS, Karina Lucio de Medeiros; RODRIGUEZ, Isadora Souza; JOHNSTON, Cintia; DELGADO, Artur Figueiredo
    SARS-CoV-2 shares nearly 80% of its' genomic sequence with SARS-CoV and MERS-CoV, both viruses known to cause respiratory symptoms and liver impairment. The emergence of pediatric cases of multisystem inflammatory syndrome related to the SARS-CoV-2 infection (PIM-TS) has raised concerns over the issue of hepatic damage and liver enzyme elevation in the critically ill pediatric population with COVID-19. Some retrospective cohorts and case series have shown various degrees of ALT/AST elevation in SARS-CoV-2 infections. A limited number of liver histopathological studies are available that show focal hepatic periportal necrosis. This liver damage was associated with higher levels of inflammatory markers, C-reactive protein (CRP), and pro-calcitonin. Proposed pathophysiological mechanisms include an uncontrolled exacerbated inflammatory response, drug-induced liver injury, direct viral infection and damage to cholangiocytes, hypoxic-ischemic lesions, and micro-thrombosis in the liver. Based on the physiopathological characteristics described, our group proposes a clinical protocol for the surveillance, evaluation, management, and follow-up of critically ill pediatric COVID-19 patients with liver damage.
  • article 20 Citação(ões) na Scopus
    Gastrointestinal manifestations and nutritional therapy during COVID-19 pandemic: a practical guide for pediatricians
    (2020) OBA, Jane; CARVALHO, Werther Brunow de; SILVA, Clovis Artur; DELGADO, Artur Figueiredo
    Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has spread globally in pandemic proportions. Accumulative evidence suggests SARS-CoV-2 can be transmitted through the digestive system, the so-called fecal-oral route of transmission, and may induce several gastrointestinal manifestations. MEDLINE (R) and Embase databases were extensively searched for major clinical manifestations of gastrointestinal involvement in children and adolescents with COVID-19 reported in medical literature, and for nutritional therapy-related data. Findings and recommendations were pragmatically described to facilitate overall pediatric approach. A total of 196 studies addressing gastrointestinal or nutritional aspects associated with the global COVID-19 pandemic were found. Of these, only 17 focused specifically on pediatric patients with regard to aforementioned gastrointestinal or nutritional aspects. Most articles were descriptive and six addressed guidelines, established protocols, or expert opinions. Children and adolescents with gastrointestinal symptoms, such as nausea, vomiting and diarrhea, should be seriously suspected of COVID-19. Gastrointestinal signs and symptoms may occur in 3% to 79% of children, adolescents and adults with COVID-19, and are more common in severe cases. These include diarrhea (2% to 50%), anorexia (40% to 50%), vomiting (4% to 67%), nausea (1% to 30%), abdominal pain (2% to 6%) and gastrointestinal bleeding (4% to 14%). Patients with inflammatory bowel disease or chronic liver disease are not at greater risk of infection by SARS-CoV-2 relative to the general population. Nutritional support plays an important role in treatment of pediatric patients, particularly those with severe or critical forms of the disease. The digestive system may be a potential route of COVID-19 transmission. Further research is needed to determine whether the fecal-oral route may be involved in viral spread. Nutritional therapy is vital to prevent malnutrition and sarcopenia in severe cases.
  • article 2 Citação(ões) na Scopus
    Revisão sistemática das escalas utilizadas para avaliação funcional na doença de Pompe
    (2012) SAVEGNAGO, Alana Karla; SILVA, Rosângela Maria da; JONHSTON, Cíntia; MARTINS, Ana Maria; MELO, Ana Paula L. de; CARVALHO, Werther Brunow de
    OBJECTIVE: To identify functional assessment scales used in Pompe disease (PD) and to describe their levels of evidence and grades of recommendation. DATA SOURCE: Systematic review of the functional assessment scales used in PD. Review conducted in the databases Medline, Lilacs, Cochrane Central Register of Controlled Trials (CCTR), and SciELO including articles (except review articles) published between 2000 and 2010. The key-words used in Portuguese and English were: glycogen storage disease type II, activities of daily living, assessment. The articles were classified according to their level of evidence and grade of recommendations. DATA SYNTHESIS: 14 studies assessing patients ranging from newborns to adults were included in the present review (total sample=449). The scales found in the literature were: Pediatric Evaluation of Disability Inventory (PEDI) and its adapted version for PD (Pompe-PEDI), Alberta Infant Motor Scale (AIMS), Rotterdam Handicap Scale (RHS), Functional Independence Measure (FIM), Gross Motor Function Measure (GMFM), and Peabody Developmental Motor Scales (PDMS-II). Most studies had level of evidence III because they were non-randomized studies. The grades of recommendation of the scales were C for AIMS and Pompe-PEDI, D for GMFM and PDMS-II; and E for RHS and FIM. CONCLUSIONS: Most functional assessment scales used in PD show low level of evidence and grade of recommendation. The scales showing the highest grade of recommendation (C) were the AIMS and Pompe-PEDI used in Pediatrics.
  • article 1 Citação(ões) na Scopus
    Early Mobilization in PICU: Are We on Time?
    (2019) JOHNSTON, C.; KREBS, V.L.J.; CARVALHO, W.B. de; CARNEIRO-SAMPAIO, M.
    Purpose of review: Elements based on specific literature to assist in the elaboration of an early mobilization (EM) protocol for severely ill children in a pediatric intensive care unit or in an inpatient care unit. Recent findings: Recent findings have shown that immobility during critical periods of the disease may cause physical, neuromusculoskeletal, metabolic, cognitive, and psychological sequelae that may extend throughout life. Prolonged bed rest is associated with thromboembolic events, decreased protein synthesis and muscle mass, and increased risk of death. Children surviving from serious illnesses have an increased risk of delay in overall recovery, resulting in poor quality of life and increased costs of post-discharge health services in the short, medium, and long term. Summary: Further research is needed to delineate protocols for specific populations in PICU as well as to find associations between interventions in PICU with EM, and with outcome times spent in PICU and hospital, need for care after hospital discharge, death and quality of life, among others. © 2019, Springer Nature Switzerland AG.