WERTHER BRUNOW DE CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina - Docente
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina - Líder
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Latin American Consensus on the Management of Sepsis in Children: Sociedad Latinoamericana de Cuidados Intensivos Pediatricos [Latin American Pediatric Intensive Care Society] (SLACIP) Task Force: Executive Summary(2022) FERNANDEZ-SARMIENTO, Jaime; SOUZA, Daniela Carla De; MARTINEZ, Anacaona; NIETO, Victor; LOPEZ-HERCE, Jesus; LANZIOTTI, Vanessa Soares; LOPEZ, Maria del Pilar Arias; CARVALHO, Werther Brunow De; OLIVEIRA, Claudio F.; JARAMILLO-BUSTAMANTE, Juan Camilo; DIAZ, Franco; YOCK-CORRALES, Adriana; RUVINSKY, Silvina; MUNAICO, Manuel; PAVLICICH, Viviana; IRAMAIN, Ricardo; MARQUEZ, Marta Patricia; GONZALEZ, Gustavo; YUNGE, Mauricio; TONIAL, Cristian; CRUCES, Pablo; PALACIO, Gladys; GRELA, Carolina; SLOCKER-BARRIO, Maria; CAMPOS-MINO, Santiago; GONZALEZ-DAMBRAUSKAS, Sebastian; SANCHEZ-PINTO, Nelson L.; GARCIA, Pedro Celiny; JABORNISKY, Roberto
- Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2)(2023) EMERIAUD, Guillaume; LOPEZ-FERNANDEZ, Yolanda; IYER, Narayan Prabhu; BEMBEA, Melania M.; AGULNIK, Asya; BARBARO, Ryan P.; BAUDIN, Florent; BHALLA, Anoopindar; CARVALHO, Werther Brunow de; CARROLL, Christopher L.; CHEIFETZ, Ira M.; CHISTI, Mohammod J.; CRUCES, Pablo; CURLEY, Martha A. Q.; DAHMER, Mary K.; DALTON, Heidi J.; ERICKSON, Simon J.; ESSOURI, Sandrine; FERNANDEZ, Analia; FLORI, Heidi R.; GRUNWELL, Jocelyn R.; JOUVET, Philippe; KILLIEN, Elizabeth Y.; KNEYBER, Martin C. J.; KUDCHADKAR, Sapna R.; KORANG, Steven Kwasi; LEE, Jan Hau; MACRAE, Duncan J.; MADDUX, Aline; I, Vicent M. Alapont; MORROW, Brenda M.; NADKARNI, Vinay M.; NAPOLITANO, Natalie; NEWTH, Christopher J. L.; PONS-ODENA, Marti; QUASNEY, Michael W.; RAJAPREYAR, Prakadeshwari; RAMBAUD, Jerome; RANDOLPH, Adrienne G.; RIMENSBERGER, Peter; ROWAN, Courtney M.; SANCHEZ-PINTO, L. Nelson; SAPRU, Anil; SAUTHIER, Michael; SHEIN, Steve L.; SMITH, Lincoln S.; STEFFEN, Katerine; TAKEUCHI, Muneyuki; THOMAS, Neal J.; TSE, Sze Man; VALENTINE, Stacey; WARD, Shan; WATSON, R. Scott; YEHYA, Nadir; ZIMMERMAN, Jerry J.; KHEMANI, Robinder G.OBJECTIVES:We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed. DESIGN:International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science. SETTING:Not applicable. PATIENTS:Patients with or at risk for PARDS. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations for clinical practice; 112 consensus-based statements with 18 on PARDS definition, 55 on good practice, seven on policy, and 32 on research. All recommendations and statements had agreement greater than 80%. CONCLUSIONS:PALICC-2 recommendations and consensus-based statements should facilitate the implementation and adherence to the best clinical practice in patients with PARDS. These results will also inform the development of future programs of research that are crucially needed to provide stronger evidence to guide the pediatric critical care teams managing these patients.
- A Core Outcome Set for Pediatric Critical Care*(2020) FINK, Ericka L.; MADDUX, Aline B.; PINTO, Neethi; SORENSON, Samuel; NOTTERMAN, Daniel; DEAN, J. Michael; CARCILLO, Joseph A.; BERG, Robert A.; ZUPPA, Athena; POLLACK, Murray M.; MEERT, Kathleen L.; HALL, Mark W.; SAPRU, Anil; MCQUILLEN, Patrick S.; MOURANI, Peter M.; WESSEL, David; AMEY, Deborah; ARGENT, Andrew; CARVALHO, Werther Brunow de; BUTT, Warwick; CHOONG, Karen; CURLEY, Martha A. Q.; LOPEZ, Maria del Pilar Arias; DEMIRKOL, Demet; GROSSKREUZ, Ruth; HOUTROW, Amy J.; KNOESTER, Hennie; LEE, Jan Hau; LONG, Debbie; MANNING, Joseph C.; MORROW, Brenda; SANKAR, Jhuma; SLOMINE, Beth S.; SMITH, McKenna; OLSON, Lenora M.; WATSON, R. ScottObjectives: More children are surviving critical illness but are at risk of residual or new health conditions. An evidence-informed and stakeholder-recommended core outcome set is lacking for pediatric critical care outcomes. Our objective was to create a multinational, multistakeholder-recommended pediatric critical care core outcome set for inclusion in clinical and research programs. Design: A two-round modified Delphi electronic survey was conducted with 333 invited research, clinical, and family/advocate stakeholders. Stakeholders completing the first round were invited to participate in the second. Outcomes scoring greater than 69% ""critical"" and less than 15% ""not important"" advanced to round 2 with write-in outcomes considered. The Steering Committee held a virtual consensus conference to determine the final components. Setting: Multinational survey. Patients: Stakeholder participants from six continents representing clinicians, researchers, and family/advocates. Measurements and Main Results: Overall response rates were 75% and 82% for each round. Participants voted on seven Global Domains and 45 Specific Outcomes in round 1, and six Global Domains and 30 Specific Outcomes in round 2. Using overall (three stakeholder groups combined) results, consensus was defined as outcomes scoring greater than 90% ""critical"" and less than 15% ""not important"" and were included in the final PICU core outcome set: four Global Domains (Cognitive, Emotional, Physical, and Overall Health) and four Specific Outcomes (Child Health-Related Quality of Life, Pain, Survival, and Communication). Families (n = 21) suggested additional critically important outcomes that did not meet consensus, which were included in the PICU core outcome set-extended. Conclusions: The PICU core outcome set and PICU core outcome set-extended are multistakeholder-recommended resources for clinical and research programs that seek to improve outcomes for children with critical illness and their families.