FERNANDO BACAL
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
18 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 18
- Heart Failure – Pathophysiology and Current Therapeutic Implications(2020) BELLO, Mariana Vieira de Oliveira; BACAL, Fernando
conferenceObject Prevalence of Cognitive Impairment in Heart Transplant Waiting-List Patients in a Developing Country(2020) OLIVEIRA, F. M. de; IKEDA, E. T.; AVILA, M.; WOZNIAK, I.; SEGURO, L.; SANTOS, M.; FELTRIM, M.; BARONE, F.; ISSA, V.; LAGE, S.; BACAL, F.; BOCCHI, E.; GAIOTTO, F.; NOMURA, C.; MARCONDES-BRAGA, F.; MANGINI, S.- Extensive Myocardial Calcification in a Heart Transplant Patient(2020) DUARTE, Sasha B. C. P.; MANGINI, Sandrigo; AVILA, Monica S.; MONTEMOR, Marcelo L.; BACAL, Fernando
- One year follow-up Assessment of Patients Included in the Brazilian Registry of Acute Coronary Syndromes (ACCEPT)(2020) SILVA, Pedro Gabriel Melo de Barros e; BERWANGER, Otavio; SANTOS, Elizabete Silva dos; SOUSA, Antonio Carlos Sobral; CAVALCANTE, Margaret Assad; ANDRADE, Pedro Beraldo de; NEUENSCHWANDER, Fernando Carvalho; VARGAS FILHO, Hugo; GUIMARAES, Jorge Ilha; ANDRADE, Jadelson; PAOLA, Angelo Amato Vincenzo de; MALACHIAS, Marcus Vinicius Bolivar; MATTOS, Luiz Alberto Piva e; PRECOMA, Dalton Bertolim; BACAL, Fernando; DUTRA, Oscar PereiraBackground: There is lack of prospective data on evolution within one year of acute coronary syndromes (ACS) in a representative population of Brazilian patients. Objectives: To assess the prescription of evidence-based therapies, the incidence of severe outcomes and the predictors for these outcomes in a multicenter Brazilian registry of ACS patients. Methods: The ACCEPT is a prospective observational study, which included patients hospitalized with a diagnostic of ACS in 47 Brazilian hospitals. The patients were followed for a 1 year and data were collected on the medical prescription and the occurrence of major cardiovascular events (cardiovascular mortality, reinfarction and cerebrovascular accident -CVA). Values of p < 0.05 were considered statistically significant. Results: A total of 5,047 patients were included in this registry from August 2010 to April 2014. The diagnosis of ACS was confirmed in 4,782 patients (94.7%) and, among those, the most frequent diagnosis was ACS with ST segment elevation (35.8%). The rate of major cardiovascular events was 13.6 % within 1 year. Adherence to prescription of evidence-based therapy at admission was of 62.1%. Age, public service, acute myocardial infarction, CVA, renal failure, diabetes and quality of therapy were associated independently with the occurrence of major cardiovascular events. Conclusions: During the one-year follow-up of the ACCEPT registry, more than 10% of the patients had major cardiovascular events and this rate ranged according with the quality of therapy. Strategies must be elaborated to improve the use of evidence-based therapies to minimize the cardiovascular events among the Brazilian population.
conferenceObject Impact of Histidine-Tryptophan-Ketoglutarate Preservation Solution in Heart Transplantation with Extended Distance(2020) GONCALVES, F. A. Rodrigues; TRINDADE, E. M.; MANGINI, S.; GAIOTTO, F.; BACAL, F.- Bone Metabolism Impairment in Heart Transplant: Results From a Prospective Cohort Study(2020) SEGURO, Luis F. B. C.; PEREIRA, Rosa M. R.; SEGURO, Luciana P. C.; CAPARBO, Valeria F.; AVILA, Monica S.; MANGINI, Sandrigo; CAMPOS, Iascara W.; GAIOTTO, Fabio A.; MARCONDES-BRAGA, Fabiana G.; BACAL, FernandoBackground. Data on the prevention of fractures after heart transplant (HTx) are controversial in the literature. Understanding the effects of HTx on bone may guide appropriate treatments in this high-risk population. Methods. Seventy adult HTx patients were followed for 12 months. Clinical and laboratory parameters, bone mineral density, microarchitecture, and vertebral fractures were assessed at baseline (after intensive care unit discharge) and at 6 and 12 months. Patients received recommendations regarding calcium intake and vitamin D supplementation after HTx. Results. At baseline, 27% of patients had osteoporosis, associated with the length of hospitalization before HTx (P = 0.001). Bone mineral density decreased in the first 6 months, with partial recovery later. Bone microarchitecture deteriorated, mainly in the trabecular bone in the first 6 months and cortical bone in the subsequent 6 months. At baseline, 92.9% of patients had vitamin D levels <30 ng/mL and 20.0% <10 ng/mL. Patients also had calcium at the lower limit of normal, high alkaline phosphatase, and high bone resorption biomarker. These abnormalities were suggestive of impaired bone mineralization and normalized at 6 months with correction of vitamin D deficiency. The majority of vertebral fractures were identified at baseline (23% of patients). After multivariate analyses, only a lower fat mass persisted as a risk factor for vertebral fractures (odds ratio, 1.23; 95% confidence interval, 1.04-1.47; P = 0.012). Conclusions. High frequencies of densitometric osteoporosis, vitamin D deficiency, bone markers abnormalities, and vertebral fractures were observed shortly after HTx. Calcium and vitamin D supplementation should be the first step in correcting bone mineralization impairment before specific osteoporosis treatment.
- Painting the History of Brazilian Cardiology(2020) LOPES, Marcelo Antonio Cartaxo Queiroga; OLIVEIRA, Glaucia Maria Moraes de; MESQUITA, Evandro Tinoco; MELO, Marcelo Dantas Tavares de; BACAL, Fernando
- Statement - Protocol for the Reconnection of Cardiology Services with Patients During the COVID-19 Pandemic-2020(2020) BITTENCOURT, Marcio Sommer; GENEROSO, Giuliano; MELO, Pedro Henrique M. Craveiro de; PEIXOTO, Driele; MIRANDA, Erique Jose Farias Peixoto de; MESQUITA, Evandro Tinoco; BRANDAO, Andrea Araujo; SARAIVA, Jose Francisco Kerr; BARBERATO, Silvio Henrique; BACAL, Fernando; LOPES, Marcelo Antonio Cartaxo Queiroga
- COVID-19 and Hypercoagulable State: A New Therapeutic Perspective(2020) NASCIMENTO, Jorge Henrique Paiter; GOMES, Bruno Ferraz de Oliveira; CARMO JUNIOR, Plinio Resende do; PETRIZ, Joao Luiz Fernandes; RIZK, Stephanie Itala; COSTA, Isabela Bispo Santos da Silva; LACERDA, Marcus Vinicius Guimaraes; BACAL, Fernando; HAJJAR, Ludhmila Abrahao; OLIVEIRA, Glaucia Maria Moraes de
- Update of the Brazilian Guidelines for Valvular Heart Disease-2020(2020) TARASOUTCHI, Flavio; MONTERA, Marcelo Westerlund; RAMOS, Auristela Isabel de Oliveira; SAMPAIO, Roney Orismar; ROSA, Vitor Emer Egypto; ACCORSI, Tarso Augusto Duenhas; SANTIS, Antonio de; FERNANDES, Joao Ricardo Cordeiro; PIRES, Lucas Jose Tachotti; SPINA, Guilherme S.; VIEIRA, Marcelo Luiz Campos; LAVITOLA, Paulo de Lara; AVILA, Walkiria Samuel; PAIXAO, Milena Ribeiro; BIGNOTO, Tiago; TOGNA, Dorival Julio Della; MESQUITA, Evandro Tinoco; ESTEVES, William Antonio de Magalhaes; ATIK, Fernando; COLAFRANCESCHI, Alexandre Siciliano; MOISES, Valdir Ambrosio; KIYOSE, Alberto Takeshi; POMERANTZEFF, Pablo M. A.; LEMOS, Pedro A.; BRITO JUNIOR, Fabio Sandoli de; WEKSLER, Clara; BRANDAO, Carlos Manuel de Almeida; POFFO, Robinson; SIMOES, Ricardo; RASSI, Salvador; LEAES, Paulo Ernesto; MOURILHE-ROCHA, Ricardo; PENA, Jose Luiz Barros; JATENE, Fabio Biscegli; BARBOSA, Marcia de Melo; ABIZAID, Alexandre; RIBEIRO, Henrique Barbosa; BACAL, Fernando; ROCHITTE, Carlos Eduardo; FONSECA, Jose Honorio de Almeida Palma; GHORAYEB, Samira Kaissar Nasr; LOPES, Marcelo Antonio Cartaxo Queiroga; SPINA, Salvador Vicente; PIGNATELLI, Ricardo H.; SARAIVA, Jose Francisco Kerr