SILVIA MARIA DE OLIVEIRA TITAN

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  • article 0 Citação(ões) na Scopus
    Dietary acid load and the risk of events of mortality and kidney replacement therapy in people with chronic kidney disease: the Progredir Cohort Study
    (2024) MACHADO, Alisson Diego; MARCHIONI, Dirce Maria; LOTUFO, Paulo Andrade; BENSENOR, Isabela Martins; TITAN, Silvia Maria
    Background/ObjectivesThe association between dietary acid load (DAL) and chronic kidney disease (CKD) progression remains controversial. Also, there is a gap in the literature on the association between DAL and mortality. In this study, we evaluated the association between NEAP (net endogenous acid production) and PRAL (potential renal acid load) and the risk of events of all-cause mortality and kidney replacement therapy (KRT) in people with CKD.Subjects/MethodsWe included 442 patients (250 diabetics) from the Progredir Cohort Study, based in Sao Paulo, Brazil. We estimated NEAP and PRAL from dietary intake. Events of death before KRT and KRT were ascertained after a median follow-up of 5.8 and 5.1 years, respectively. Cox proportional hazards regression, Weibull regression, and competing risk models were performed.ResultsMedian NEAP and PRAL were 49.5 and 4.8 mEq/d. There were 200 deaths and 75 KRT events. Neither NEAP nor PRAL were associated with mortality or KRT when all participants were analyzed. After stratification for diabetes, both estimates were positively related to the risk of KRT even after adjustment for age, sex, weight status, glomerular filtration rate, serum bicarbonate, and intakes of protein, phosphorus, and energy (HR 1.31; 95% CI 1.07, 1.60 for NEAP, and HR 1.27; 95% CI 1.04, 1.57 for every 10 mEq/d increments). Competing risk analyses confirmed these findings.ConclusionsDAL estimates were associated with the risk of KRT in people with CKD and diabetes but not in non-diabetics. There was no association between all-cause mortality and DAL.
  • conferenceObject
    Comparison of Insulin Glargine vs. NPH Insulin in Basal-Bolus Therapies in T2DM Patients and CKD: Preliminary Results of a Prospective, Randomized, Open-Label Trial
    (2016) BETONICO, Carolina Castro Rocha; TITAN, Silvia Maria De Oliveira; CORREA-GIANNELLA, Maria Lucia; NERY, Marcia; QUEIROZ, Marcia Silva