ANA PAULA MARTE CHACRA
Índice h a partir de 2011
9
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- The Importance of Identifying Risk Factors in Childhood and Adolescence(2019) CHACRA, Ana Paula Marte
- Update on genetics and molecular biology(2019) SANTOS, Raul D.; CHACRA, Ana P.
- Case report: The efficacy and safety of lomitapide in a homozygous familial hypercholesterolemic child(2019) CHACRA, Ana Paula M.; FERRARI, Michael C.; ROCHA, Viviane Z.; SANTOS, Raul D.We report for the first time the efficiency and safety of a 49-month compassionate use of the microsomal transfer protein inhibitor lomitapide in a child with homozygous familial hypercholester-olemia. On average, 20 mg of lomitapide caused a 37% reduction in low-density lipoprotein cholesterol levels on top of ezetimibe and atorvastatin. The drug was well tolerated with no changes in liver enzymes and occurrence of steatosis on hepatic ultrasound. The patient presented adequate growth and sexual maturation. Nonetheless, there was progression in either subclinical atherosclerotic carotid or aortic valve diseases. Further studies are necessary to test the impact and safety of lomitapide in children with homozygous familial hypercholesterolemia.