ANA PAULA MARTE CHACRA
Índice h a partir de 2011
9
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
Resultados de Busca
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conferenceObject PREDICTORS OF CORONARY ARTERY CALCIFICATION INCIDENCE IN SEVERE HYPERCHOLESTEROLEMIA(2023) MARTE, Ana; MINAME, Marcio Hiroshi; PARDI, Estevao Magalhaes; GANEM, Lucas; MIZUTA, Marjorie Hayashida; ROCHA, Viviane Zorzanelli; PEREIRA, Alexandre Costa; KRIEGER, Jose Eduardo; SANTOS, Raul- Update on Sitosterolemia and Atherosclerosis(2023) ROCHA, Viviane Zorzanelli; TADA, Mauricio Teruo; CHACRA, Ana Paula Marte; MINAME, Marcio Hiroshi; MIZUTA, Marjorie H. H.Purpose of ReviewThe purpose of this review was to summarize important and updated information on sitosterolemia. Sitosterolemia is an inherited lipid disorder consisting of high levels of plasma plant sterols. This sterol storage condition is caused by biallelic loss-of-function genetic variants in either ABCG5 or ABCG8, leading to increased intestinal absorption and decreased hepatic excretion of plant sterols. Clinically, patients with sitosterolemia usually exhibit xanthomatosis, high levels of plasma cholesterol, and premature atherosclerotic disease, but presentation can be highly heterogeneous. Therefore, recognition of this condition requires a high level of suspicion, with confirmation upon genetic diagnosis or through measurement of plasma phytosterols. Treatment of sitosterolemia with both a plant sterol-restricted diet and the intestinal cholesterol absorption inhibitor ezetimibe can reduce efficiently the levels of plasma plant sterols, consisting in the first-line therapy for this disease.Recent FindingsSince hypercholesterolemia is often present in individuals with sitosterolemia, it is important to search for genetic variants in ABCG5 and ABCG8 in patients with clinical criteria for familial hypercholesterolemia (FH), but no variants in FH implicated genes. Indeed, recent studies have suggested that genetic variants in ABCG5/ABCG8 can mimic FH, and even when in heterozygosis, they may potentially exacerbate the phenotype of patients with severe dyslipidemia.Sitosterolemia is a genetic lipid disorder characterized by increased circulating levels of plant sterols and clinically manifested by xanthomatosis, hematologic disorders, and early atherosclerosis. Awareness about this condition, a rare, but commonly underdiagnosed and yet treatable cause of premature atherosclerotic disease, is imperative.
conferenceObject RAPID PROGRESSION OF CORONARY ATHEROSCLEROSIS IN A PATIENT WITH AUTOSSOMAL RECESSIVE HYPERCHOLESTEROLEMIA(2023) MIZUTA, Marjorie Hayashida; AMORIM, Matheus; ROCHA, Viviane Zorzanelli; MINAME, Marcio Hiroshi; JANNES, Cinthia Elim; PEREIRA, Alexandre Costa; KRIEGER, Jose Eduardo; SANTOS, Raul; CHACRA, Ana Paula Marte- Brazilian Position Statement for Familial Chylomicronemia Syndrome-2023(2023) IZAR, Maria Cristina de Oliveira; SANTOS FILHO, Raul Dias dos; ASSAD, Marcelo Heitor Vieira; CHAGAS, Antonio Carlos Palandri; TOLEDO JUNIOR, Alceu de Oliveira; NOGUEIRA, Ana Claudia Cavalcante; SOUTO, Ana Cristina Carneiro Fernandes; LOTTENBERG, Ana Maria Pitta; CHACRA, Ana Paula Marte; FERREIRA, Carlos Eduardo dos Santos; LOURENCO, Charles Marques; VALERIO, Cynthia Melissa; CINTRA, Dennys Esper; FONSECA, Francisco Antonio Helfenstein; CAMPANA, Gustavo Aguiar; BIANCO, Henrique Tria; LIMA, Josivan Gomes de; CASTELO, Maria Helane Costa Gurgel; SCARTEZINI, Marileia; MORETTI, Miguel Antonio; BARRETO, Natasha Slhessarenko Fraife; MAIA, Rayana Elias; MONTENEGRO JUNIOR, Renan Magalhaes; ALVES, Renato Jorge; FIGUEIREDO, Roberta Marcondes Machado; FOCK, Rodrigo Ambrosio; MARTINEZ, Tania Leme da Rocha(iii) any legal person in which any of these is either a direct or indirect controlling owner, business partner, shareholder or advisory boards, investigative boards or other committees, etc. From the brazilian or international pharmaceutical, orthosis, Funding of continuing medical education activities, including travel, accommodation and registration in conferences and Any economically relevant equity interest in companies in the healthcare or education industry or in any companies competing
conferenceObject SITOSTEROLEMIA AND PREMATURE CORONARY ATHEROSCLEROSIS IN A YOUNG WOMAN: A CASE REPORT.(2023) CORSO, Mariana P. Xerfan; MARTINHAGO, Gustavo; BORGES, Kartagena; BECERE, Matheus AndraDe lazzari; CHACRA, Ana Paula Marte; MIZUTA, Marjorie Hayashida; MINAME, Marcio Hiroshi; SANTOS, Raul; ROCHA, Viviane ZorzanellibookPart Diabetes e lípides(2023) SANTOS, Raul Dias dos; CHACRA, Ana Paula