CAIO SERGIO RIZKALLAH NAHAS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
21 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 21
- Long-term follow up of abdominal rectosigmoidectomy with posterior end-to-side stapled anastomosis for Chagas megacolon(2011) NAHAS, S. C.; PINTO, R. A.; DIAS, A. R.; NAHAS, C. S. R.; ARAUJO, S. E. A.; MARQUES, C. F. S.; CECCONELLO, I.Aim Chagas' disease is an endemic parasitosis found in Latin America. The disease affects different organs, such as heart, oesophagus, colon and rectum. Megacolon is the most frequent long-term complication, caused by damage to the myoenteric and submucous plexus, ultimately leading to a functional barrier to the faeces. Patients with severe constipation are managed surgically. The study aimed to analyse the 10-year minimum functional outcome after rectosigmoidectomy with posterior end-to-side anastomosis (RPESA). Method A total of 21 of 46 patients were available for follow up. Patients underwent clinical, radiological and manometric evaluation, and the results were compared with preoperative parameters. Results Of the 21 patients evaluated, 81% (17) were female, with a mean age of 60.6 years. Good function was achieved in all patients, with significant improvement in defaecatory frequency (P < 0.0001), usage of enemas (P < 0.0001) and patient satisfaction. Barium enema also showed resolution of the colonic and rectal dilatation in 19 cases evaluated postoperatively. Conclusion Minimal 10-year follow up of RPESA showed excellent functional results, with no recurrence of constipation.
- Outcomes of surgical treatment for patients with distal rectal cancer: A retrospective review from a single university hospital(2020) NAHAS, S. C.; NAHAS, C. S. R.; BUSTAMANTE-LOPEZ, L. A.; PINTO, R. A.; MARQUES, C. F. S.; CECCONELLO, I.introduction and aim: Surgery for distal rectal cancer (DRC) can be performed with or without sphincter preservation. The aim of the present study was to analyze the outcomes of two surgical techniques in the treatment of DRC patients: low anterior resection (LAR) and abdominoperineal resection (APR). Methods: Patients with advanced DRC that underwent surgical treatment between 2002 and 2012 were evaluated. We compared the outcomes of the type of surgery (APR vs LAR) and analyzed the associations of survival and recurrence with the following factors: age, sex, tumor location, lymph nodes obtained, lymph node involvement, and rectal wall involvement. Patients with distant metastases were excluded. Results: A total of 148 patients were included, 78 of whom were females (52.7%). The mean patient age was 61.2 years. Neoadjuvant chemoradiation therapy was performed in 86.5% of the patients. APR was performed on 86 (58.1%) patients, and LAR on 62 (41.9%) patients. No differences were observed between the two groups regarding clinical and oncologic characteristics. Eighty-seven (62%) patients had pT3-4 disease, and 41 patients (27.7%) had lymph node involvement. In the multivariate analysis, only poorly differentiated tumors (P=.026) and APR (P=.009) correlated with higher recurrence rates. Mean follow-up time was 32 (16-59.9) months. Overall 5 -year survival was 58.1%. The 5 -year survival rate was worse in patients that underwent APR (46.5%) than in the patients that underwent LAR (74.2%) (P=.009). Conclusions: Patients with locally advanced DRC that underwent APR presented with a lower survival rate and a higher local recurrence rate than patients that underwent LAR. In addition, advanced T/stage, lymph node involvement, and poor tumor differentiation were associated with recurrence and a lower survival rate, regardless of the procedure. 2020 Asociacion Mexicana de Gastroenterologia.
conferenceObject POSTOPERATIVE TEM COMPLICATIONS FOR THE TREATMENT OF RECTAL NEOPLASIA ARE FREQUENT BUT MILD. RISK FACTORS AND TIME BEHAVIOR STUDY(2014) MARQUES, C.; NAHAS, C.; RIBEIRO, U.; BUSTAMANTE, L.; PINTO, R.; MORY, E.; CECCONELLO, I.; NAHAS, S.conferenceObject LAPAROSCOPIC RIGHT COLECTOMY WITH EXTRACORPOREAL ANASTOMOSIS HAS HIGHER MORBIDITY COMPARED TO INTRACORPOREAL ANASTOMOSIS?(2017) PINTO, R.; GERBASI, L.; CAMARGO, M.; KIMURA, C.; SOARES, D.; BUSTAMANTE-LOPEZ, L.; NAHAS, C.; CAMPOS, F.; CECCONELLO, I.; NAHAS, S.- Understanding the factors associated with reduction in the number of lymph nodes in rectal cancer patients treated by neoadjuvant treatment(2017) BUSTAMANTE-LOPEZ, L.; NAHAS, C. S.; NAHAS, S. C.; RIBEIRO JR., U.; MARQUES, C. F.; COTTI, G.; ROCCO, A.; CECCONELLO, I.Introduction Rectal cancer patients frequently present with locally advanced disease for which the standard of care includes neoadjuvant chemoradiotherapy followed by total mesorectal excision. Positive lymph nodes are one of the most powerful risk factors for recurrence and survival in colorectal cancer. In the absence of specific rectal guidelines, the literature recommends to the pathologist to optimize the number of rectal lymph nodes (LN) retrieved. We made a literature review in order to identify factors that could potentially affect the number of LN retrieved in specimens of patients with rectal cancer treated by chemoradiotherapy (CRT) followed by total mesorectal excision (TME). Results Age did not have a significant effect on LN yield. The effect of sex on LN number is not consistent in the literature. Most of the papers did not find a relationship between lower LN obtained and gender. Laparoscopy for primary rectal cancer is associated with a greater number of LN as well as shortterm benefits. Tumors in the upper rectum are associated with a higher number of LN than those in the mid and lower rectum. The type of surgery had no effect on lymph node yield either. Tumors with complete or almost complete pathologic regression were exactly the ones with lower number of lymph nodes detected. Approximately one-third of patients with neoadjuvant treatment had less than 12 LN yield. Conclusion The tumor regression grade is the most important factor for the decrease in the number of lymph nodes.
conferenceObject EFFICACY OF TRIDIMENSIONAL ENDORECTAL ULTRASOUND IN COMPARISON TO HISTOPATHOLOGY FOR EVALUATION EXTRA PERITONEAL RECTAL NEOPLASMS.(2015) PINTO, R.; CORREA NETO, I.; NAHAS, S.; NAHAS, C.; MARQUES, C.; RIBEIRO JUNIOR, U.; BUSTAMANTE-LOPEZ, L.; SOARES, D.; CECCONELLO, I.conferenceObject OUTCOMES OF NONSURGICAL TREATMENT IN PATIENTS WITH CLINICAL COMPLETE RESPONSE AFTER NEOADJUVANT THERAPY FOR RECTAL CANCER.(2016) COTTI, G.; NAHAS, C.; MARQUES, C.; IMPERIALE, A.; RIBEIRO JUNIOR, U.; NAHAS, S.; CECCONELLO, I.; HOFF, P.conferenceObject OBSERVATION VERSUS SURGICAL RESECTION IN PATIENTS WITH RECTAL CANCER WHO ACHIEVED COMPLETE CLINICAL RESPONSE AFTER NEOADJUVANT CHEMORADIOTHERAPY: PRELIMINARY RESULTS OF A RANDOMIZED TRIAL (NCT02052921).(2015) NAHAS, S.; NAHAS, C.; RIBEIRO JUNIOR, U.; MARQUES, C. Sparapan; COTTI, G. C.; IMPERIALE, A.; ORTEGA, C.; AZAMBUJA, R.; CHEN, A.; HOFF, P.; CECCONELLO, I.article 0 Citação(ões) na Scopus Rectal gist resection following neoadjuvant therapy. Reporting two cases from a single institute [Resección del gist rectal tras la terapia neo-adyuvante. Relato de dos casos de un único instituto](2020) PANDINI, R.V.; JúNIOR, S.S.; PINTO, R.A.; NAHAS, C.S.R.; TUSTUMI, F.; PINHEIRO, R.B.B.; JúNIOR, U.R.; NAHAS, S.C.; CECCONELLO, I.Gastrointestinal stromal tumours (GIST) are the most common neoplasms arising from the mesenchymal cells of the gastrointestinal tract. Although GIST can arise in any gastrointestinal site, the most common are stomach and small bowel. Less than 5% of all GIST are located in rectum. Surgery is the main treatment option for resectable GIST. Current-ly, local excision has been increasingly employed thanks to neoadjuvant therapy. This paper reports two cases of rectal GIST treated with Imatinib neoadjuvant therapy followed by trans anal local resection. © 2020, Sociedad Argentina de Gastroenterologia. All rights reserved.conferenceObject ANALYSIS OF RISK FACTORS FOR POSTOPERATIVE COMPLICATIONS IN PATIENTS WHO UNDERWENT CLOSURE OF ILEOSTOMY AFTER COLORECTAL CANCER RESECTION.(2016) SOARES, D.; NAHAS, C.; CAMARGO, M.; PINTO, R.; MARQUES, C.; RIBEIRO JUNIOR, U.; NAHAS, S.; CECCONELLO, I.
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