LILIAM TAKAYAMA GUERRA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
38 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 38
- EFFECT OF SARCOPENIA, SUBCUTANEOUS ADIPOSE TISSUE AND ABDOMINAL VISCERAL FAT ON MORTALITY RISK OF COMMUNITY-DWELLING OLDER ADULTS: A POPULATION-BASED PROSPECTIVE COHORT STUDY IN BRAZIL(2017) SANTANA, F. M.; DOMICIANO, D.; GONCALVES, M.; MACHADO, L. G.; FIGUEIREDO, C. P.; LOPES, J. B.; CAPARBO, V.; TAKAYAMA, L.; PEREIRA, . M. R.
conferenceObject PREVALENCE OF SARCOPENIA AND ASSOCIATED RISK FACTORS BY TWO DIAGNOSTIC CRITERIA IN COMMUNITY-DWELLING OLDER WOMEN: THE SAO PAULO AGEING & HEALTH STUDY (SPAH)(2016) DOMICIANO, D. S.; FIGUEIREDO, C. P.; LOPES, J. B.; CAPARBO, V. F.; TAKAYAMA, L.; MENEZES, P. R.; PEREIRA, R. M.conferenceObject Discriminating sarcopenia in male patients with heart failure: the influence of body mass index(2018) SANTOS, M. R. Dos; FONSECA, G. W. P.; SOUZA, F. R.; CASTRO, V. M.; TAKAYAMA, L.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. N.- HIGH INCIDENCE OF HIP FRACTURE AND NON-VERTEBRAL OSTEOPOROTIC FRACTURE IN LOW INCOME COMMUNITY-DWELLING ELDERLY: A POPULATION-BASED PROSPECTIVE COHORT STUDY IN BRAZIL. THE SAO PAULO AGEING & HEALTH (SPAH) STUDY(2014) DOMICIANO, D. S.; MACHADO, L. G.; LOPES, J.; FIGUEIREDO, C.; MENEZES, P.; CAPARBO, V.; TAKAYAMA, L.; PEREIRA, R. M. R.
conferenceObject DISCRIMINATING SARCOPENIA IN COMMUNITY-DWELLING OLDER WOMEN WITH HIGH FREQUENCY OF OVERWEIGHT/OBESITY: PREVALENCE AND ASSOCIATED RISK FACTORS - THE SAO PAULO AGEING & HEALTH STUDY (SPAH)(2012) DOMICIANO, D.; LOPES, J. B.; FIGUEIREDO, C. P.; CAPARBO, V.; TAKAYAMA, L.; BONFA, E.; PEREIRA, R. M. R.conferenceObject Low bone mineral density and muscle mass in common variable immunodeficiency patients: Association with CD4+T cells and B cells(2019) BARROS, M. Toledo; MELO, D. Barreto De; PEREIRA, R. M. Rodrigues; SINI, B.; COUTINHO, E. M.; TAKAYAMA, L.; KOKRON, C. M.; MARINHO, A. K.; GRECCO, O.; KALIL, J.; ANTILA, H. G.conferenceObject Impact of exercise training and testosterone replacement on skeletal muscle atrophy and muscle sympathetic nerve activity in heart failure patients with hypogonadism(2014) SANTOS, M. R. Dos; SAYEGH, A. L.; BACURAU, A. V. N.; ARAP, M. A.; PEREIRA, R. M. R.; BRUM, P. C.; TAKAYAMA, L.; PEREIRA, A. C.; ALVES, M. J. N. N.conferenceObject BONE MINERAL DENSITY AND PARATHYROID HORMONE AS INDEPENDENT RISK FACTORS FOR MORTALITY IN COMMUNITY-DWELLING OLDER ADULTS: A POPULATION-BASED PROSPECTIVE COHORT STUDY IN BRAZIL. THE SAO PAULO AGEING & HEALTH (SPAH) STUDY(2016) DOMICIANO, D.; MACHADO, L.; LOPES, J.; FIGUEIREDO, C.; CAPARBO, V.; TAKAYAMA, L.; OLIVEIRA, R.; SCAZUFCA, M.; MCCLUNG, M.; PEREIRA, R.conferenceObject VERTEBRAL FRACTURE ASSESSMENT (VFA): A VALID TOOL TO DETECT VERTEBRAL FRACTURES IN COMMUNITY-DWELLING OLDER INDIVIDUALS - THE SAO PAULO AGEING & HEALTH STUDY (SPAH)(2012) DOMICIANO, D.; LOPES, J. B.; FIGUEIREDO, C. P.; CAPARBO, V.; TAKAYAMA, L.; BONFA, E.; PEREIRA, R. M. R.Aims: Vertebral fractures (VFx) are associated with higher morbidity and mortality in the general population. Since 70 % of the VFx are clinically silent, radiologic image of spine has to be acquired for the diagnosis. Vertebral Fracture Assessment (VFA) has emerged as possible alternative for the gold standard radiologic image to detect prevalent VFx. Previous studies evaluating this method are hampered by the limited sample size, selection of women with specific indication for spine X-ray and inclusion of patients under 70 years. Thus, the aim of this study was to compare the performance of VFA with X-ray to identify VFx in healthy community-dwelling older men and women. Methods: 429 noninstitutionalized subjects (60 % women), aged over 65 years, from community, were enrolled in this cohort. VFA by DXA measurements was evaluated by two expert rheumatologists by consensus and spine X-ray (T4 to L4) were analyzed according to semiquantitative method (Genant HK, 1993) by an expert radiologist. The correlation between VFA and spine X-ray to identify VFx was analyzed by kappa ( κ ) scores. P<0.05 was set as significant. Results: The average age ofsubjects was 73.1±5.1 years.The prevalence of VFx in VFA and X-ray were 29.7 and 28.6 % in women (p= 0.69), and 28.2 and 30.6 % in men (p=0.50), respectively. The frequency of unavailable vertebrae was significantly lower in spine X-ray than VFA (0.9 % and 5.6 %, respectively, p<0.001), particularly along with T4-T6. According to VFA, 5013 (96 %) vertebrae were identified as normal, 144 (2.7 %) had grade 1 fractures, 58 (1.1 %) grade 2 fractures and 12 (0.2) grade 3 fractures. The sensitivity of VFA was 72.93 % and the specificity was 99.1 % to identify VFx. The sensitivity increased to 92 % and specificity to 99.9 % excluding deformities grade 1. A good correlation between VFA and X-ray (κ=0.74) was observed and the exclusion of grade 1 resulted in an even better agreement(κ=0.84). The correlation vertebrae by vertebrae between VFA and spine X-ray was lower for T4-T7 (0.61-0.67). Correlations between the two methods were comparable in both gender (κ=0.73 in men,κ=0.75 in women). Conclusion: In elderly community, VFA and X-ray had comparable performances to identify VFx, particularly if mild deformities are excluded. Thus, this methodology is an easy and feasible promising alternative to improve the identification and management of patients with high risk of osteoporotic fractures.- Risk factors for bone loss in juvenile-onset systemic lupus erythematosus: a prospective study(2019) SOUSA, L. F. A. de; PAUPITZ, J. A.; AIKAWA, N. E.; TAKAYAMA, L.; CAPARBO, V. F.; PEREIRA, R. M. R.Objective Juvenile-onset systemic lupus erythematosus (JoSLE) is associated with low bone mass for age and fractures; nevertheless, risk factors for bone impairment are poorly understood. The aim of this study was to evaluate risk factors for bone mass loss in JoSLE patients. Methods Forty-nine female JoSLE patients were evaluated at baseline and after a 3.5-year follow-up regarding clinical, laboratory (including bone turnover markers), areal bone mineral density (aBMD) and bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT). Based on the difference between final and baseline aBMD value, the patients were divided into three groups: aBMD gain (BG), aBMD loss (BL) and aBMD no change (NC). Results The mean patient age was 18.7 +/- 3.3 years. Sixty-one percent of patients presented with aBMD gain, 18.4% aBMD loss, and 20.4% remained stable during this follow-up period. Comparing the BL with the BG group, there was a higher frequency of alcohol consumption (p = 0.009), a higher frequency of inadequate calcium intake (p = 0.047) and lower levels of baseline procollagen type 1 amino-terminal propeptide (P1NP) (p = 0.036) in the BL group. Moreover, worsening of HR-pQCT parameters trabecular volumetric density (p = 0.003) and cortical thickness (p = 0.009) was observed in the BL group. In addition, a higher frequency of renal activity was observed comparing the BL + NC with the BG group (p = 0.036). Conclusions This is the first longitudinal study that has analyzed the risk factors of bone loss in JoSLE patients. The authors emphasize the importance of evaluating lifestyle habits and renal disease activity in these young women. Furthermore, this study suggests that trabecular and cortical compartments deteriorated, and low levels of P1NP may be a predictor of bone impairment in JoSLE.