LILIAM TAKAYAMA GUERRA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- EFFECT OF SARCOPENIA, SUBCUTANEOUS ADIPOSE TISSUE AND ABDOMINAL VISCERAL FAT ON MORTALITY RISK OF COMMUNITY-DWELLING OLDER ADULTS: A POPULATION-BASED PROSPECTIVE COHORT STUDY IN BRAZIL(2017) SANTANA, F. M.; DOMICIANO, D.; GONCALVES, M.; MACHADO, L. G.; FIGUEIREDO, C. P.; LOPES, J. B.; CAPARBO, V.; TAKAYAMA, L.; PEREIRA, . M. R.
- Low bone mineral density among HIV-infected patients in Brazil(2017) CHABA, Daniela Cardeal da Silva; SOARES, Lismeia R.; PEREIRA, Rosa M. R.; RUTHERFORD, George W.; ASSONE, Tatiane; TAKAYAMA, Liliam; FONSECA, Luiz A. M.; DUARTE, Alberto J. S.; CASSEB, JorgeDecrease in bone mineral density (BMD) has been a complication among people living with HIV/AIDS. To investigate the prevalence of osteopenia/osteoporosis among HIV-infected people living in Sao Paulo city, we studied 108 HIV-infected patients (79 men and 29 women). We extracted data from patients' medical records and BMD was measured by dual-energy X-ray absorptiometry (DXA). Median age of participants was 42 years (interquartile range [IQR] 36-48 years), and the median time since HIV diagnosis was 4.01 years (IQR 2-11 years). Patients had acquired HIV primarily by the sexual route (men who have sex with men 44%, heterosexual 49%). Median age, duration of HIV infection, duration of ART and CD4 nadir were similar for men and women. Plasma viral load was undetectable for 53 patients (49%). Median CD4 T cell count was 399 cells/mu L (IQR 247 - 568). Twenty five patients (23%) had LBMD, and there was no statistically significant difference between men and women (<-1). The associated risk factors for LBMD were older age (>= 50 years old) and smoking with a RR of 3.87 and 2.80, respectively. Thus, despite the lack of statistically significant relationship between the use of ART and LBMD or between duration of ART and LBMD, these factors should be addressed in larger studies.
conferenceObject Exacerbated muscle sympathetic nerve activity and blunted vagal reactivation in patients with heart failure and sarcopenia(2017) FONSECA, G. W. P.; SANTOS, M. R. Dos; SOUZA, F. R. De; PORELLO, R. A.; COSTA, M. J. A. Da; TAKAYAMA, L.; PEREIRA, R. M. R.; NEGRAO, C. E.; ALVES, M. J. N. NunesconferenceObject ASSOCIATION BETWEEN METABOLIC SYNDROME AND BONE MINERAL DENSITY IN COMMUNITY-DWELLING OLDER WOMEN: THE SAO PAULO AGEING AND HEALTH STUDY (SPAH)(2017) MACHADO, L. G.; DOMICIANO, D. S.; FIGUEIREDO, C. P.; LOPES, J. B.; CAPARBO, V. F.; TAKAYAMA, L.; OLIVEIRA, R.; PEREIRA, R. M.- Evaluation of bone mineral density and microarchitectural parameters by DXA and HR-pQCT in 37 children and adults with X-linked hypophosphatemic rickets(2017) COLARES NETO, G. P.; PEREIRA, R. M. R.; ALVARENGA, J. C.; TAKAYAMA, L.; FUNARI, M. F. A.; MARTIN, R. M.In X-linked hypophosphatemic (XLH) rickets, dual-energy X-ray absorptiometry (DXA) measurements must be analyzed with caution. High-resolution peripheral quantitative computed tomography (HR-pQCT) analysis suggested that XLH primarily affects the cancellous compartment, with the tibia more affected than the radius. Effective treatment of XLH appears to positively affect bone mineralization, mainly in the bone cortex. The purpose of this study is to evaluate bone mineral density (BMD) and microarchitecture in 37 patients (13 children and 24 adults) with XLH confirmed by PHEX mutations from a tertiary center compared to healthy controls. Areal BMD (aBMD) was evaluated by DXA, whereas volumetric BMD (vBMD) and microarchitectural parameters were analyzed by HR-pQCT. Adult XLH patients had higher lumbar aBMD (p < 0.01) than the controls. At the radius, the vBMD was similar between XLH patients and controls. At the tibia, XLH patients had lower total vBMD (p = 0.04), likely resulting from decreased trabecular vBMD (p < 0.01), and this difference was observed in the children and adult groups. Analysis based on metabolic status showed that the adult XLH patients with non-compensated disease had lower cortical vBMD at the tibia than the compensated XLH patients (p = 0.03). The microarchitectural differences at the radius and tibia included lower trabecular number (p < 0.01), greater trabecular separation (p < 0.01), and higher trabecular network inhomogeneity (p < 0.01) in XLH patients compared to their controls. At the radius, adults exhibited greater trabecular deficits than were seen in children. In XLH patients, DXA measurements must be analyzed with caution due to the interference of anatomic and anthropometric factors. HR-pQCT analysis suggested that XLH primarily affects the cancellous compartment, with the tibia more affected than the radius. Effective treatment of XLH appears to positively affect bone mineralization, mainly in the bone cortex.
conferenceObject Risk Factors for Bone Loss in Juvenile-Onset Systemic Lupus Erythematosus: A Prospective Study(2017) SOUSA, Luiz A.; PAUPITZ, Juliane; AIKAWA, Nadia E.; TAKAYAMA, Liliam; CAPARBO, Valeria F.; PEREIRA, Rosa M. R.conferenceObject Risk Factors for Low Muscle MASS in Community-Dwelling Older Women: A Population-Based Prospective Cohort Study in Brazil. the Sao Paulo Ageing & Health Study(2017) MACHADO, Ketty; DOMICIANO, Diogo S.; MACHADO, Luana G.; LOPES, Jaqueline B.; FIGUEIREDO, Camille P.; CAPARBO, Valeria F.; TAKAYAMA, Liliam; MENEZES, Paulo; PEREIRA, Rosa M. R.conferenceObject Osteoporosis in Heart Transplant: association with pre -transplant hospitalization time(2017) SEGURO, L. F. B. C.; SEGURO, L. P. C.; MARCONDES-BRAGA, F. G.; CAPARBO, V. P.; TAKAYAMA, L.; MANGINI, S.; AVILA, M. S.; WOZNIAK, I.; GAIOTTO, F. A.; PEREIRA, R. M.; BACAL, F.conferenceObject EFFECT OF SARCOPENIA, SUBCUTANEOUS ADIPOSE TISSUE AND ABDOMINAL VISCERAL FAT ON MORTALITY RISK OF COMMUNITY-DWELLING OLDER ADULTS: A POPULATION-BASED PROSPECTIVE COHORT STUDY IN BRAZIL- THE SAO PAULO AGEING and HEALTH STUDY(2017) DOMICIANO, D. S. D.; SANTANA, F. M. S.; GONCALVES, M. A. G.; MACHADO, L. G. M.; LOPES, J. B. L.; FIGUEIREDO, C. P. F.; CAPARBO, V. C.; TAKAYAMA, L. T.; PEREIRA, R. M. R. P.