GUILHERME SOBREIRA SPINA

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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Autor e Coautores FMUSP-HC Normalizados: RONEY ORISMAR SAMPAIO × search.filters.applied.f.dateIssued: 2012 ×

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  • article 1 Citação(ões) na Scopus
    Effect of Penicillin G Every Three Weeks on Oral Microflora by Penicillin Resistant Viridans Streptococci
    (2012) AGUIAR, Andre Andrade de; SAMPAIO, Roney Orismar; SAMPAIO, Jorge Luiz de Mello; SPINA, Guilherme Sobreira; NEVES, Ricardo Simoes; MOREIRA, Luiz Felipe Pinho; GRINBERG, Max
    Background: Benzathine penicillin G every 3 weeks is the standard protocol for secondary prophylaxis for recurrent rheumatic fever. Objective: Assess the effect of Benzathine penicillin G on Streptococcus sanguinis and in patients with cardiac valvular disease due to rheumatic fever receiving secondary prophylaxis. Methods: Oral streptococci were evaluated before (baseline) and 7 days (day 7) after Benzathine penicillin G in 100 patients receiving routine secondary rheumatic fever prophylaxis. Saliva samples were evaluated for colony count and presence of S. sanguinis and S. oralis. Chewing-stimulated saliva samples were serially diluted and plated onto both nonselective and selective 5% sheep blood agar containing penicillin G. The species were identified using conventional biochemical tests. Minimal inhibitory concentrations were determined with the Etest. Results: No statistical differences were found in the presence of S. sanguinis comparing baseline and day 7 (p = 0.62). However, the existing number of positive cultures of S. oralis on day 7 after Benzathine penicillin G presented a significant increase compared to baseline (p = 0.04). No statistical difference was found between baseline and day 7 concerning the number of S. sanguinis or S. oralis CFU/mL and median minimal inhibitory concentrations. Conclusion: This study showed that Benzathine penicillin G every 3 weeks did not change the colonization by S. sanguinis, but increased colonization of S. oralis on day 7 of administration. Therefore, susceptibility of Streptococcus sanguinis and Streptococcus oralis to penicillin G was not modified during the penicillin G routine secondary rheumatic fever prophylaxis. (Arq Bras Cardiol 2012;98(5):452-458)