GUILHERME SOBREIRA SPINA

(Fonte: Lattes)
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • article 1 Citação(ões) na Scopus
    Effect of Penicillin G Every Three Weeks on Oral Microflora by Penicillin Resistant Viridans Streptococci
    (2012) AGUIAR, Andre Andrade de; SAMPAIO, Roney Orismar; SAMPAIO, Jorge Luiz de Mello; SPINA, Guilherme Sobreira; NEVES, Ricardo Simoes; MOREIRA, Luiz Felipe Pinho; GRINBERG, Max
    Background: Benzathine penicillin G every 3 weeks is the standard protocol for secondary prophylaxis for recurrent rheumatic fever. Objective: Assess the effect of Benzathine penicillin G on Streptococcus sanguinis and in patients with cardiac valvular disease due to rheumatic fever receiving secondary prophylaxis. Methods: Oral streptococci were evaluated before (baseline) and 7 days (day 7) after Benzathine penicillin G in 100 patients receiving routine secondary rheumatic fever prophylaxis. Saliva samples were evaluated for colony count and presence of S. sanguinis and S. oralis. Chewing-stimulated saliva samples were serially diluted and plated onto both nonselective and selective 5% sheep blood agar containing penicillin G. The species were identified using conventional biochemical tests. Minimal inhibitory concentrations were determined with the Etest. Results: No statistical differences were found in the presence of S. sanguinis comparing baseline and day 7 (p = 0.62). However, the existing number of positive cultures of S. oralis on day 7 after Benzathine penicillin G presented a significant increase compared to baseline (p = 0.04). No statistical difference was found between baseline and day 7 concerning the number of S. sanguinis or S. oralis CFU/mL and median minimal inhibitory concentrations. Conclusion: This study showed that Benzathine penicillin G every 3 weeks did not change the colonization by S. sanguinis, but increased colonization of S. oralis on day 7 of administration. Therefore, susceptibility of Streptococcus sanguinis and Streptococcus oralis to penicillin G was not modified during the penicillin G routine secondary rheumatic fever prophylaxis. (Arq Bras Cardiol 2012;98(5):452-458)
  • article 5 Citação(ões) na Scopus
    Association between Immunological Diseases and their Similar Clinical Manifestations
    (2012) SOEIRO, Alexandre de Matos; ALMEIDA, Maria Carolina Feres de; ACCORSI, Tarso Augusto Duenhas; SPINA, Guilherme Sobreira; SERRANO JR., Carlos Vicente; TARASOUTCHI, Flavio
    We report on a 30-year-old female patient, with biological mitral valve prosthesis due to symptomatic mitral stenosis and a history of acute myocardial infarction and generalized tonic-clonic seizure episodes, visual hallucinations, cerebral thromboembolic events and, at present, chorea and acute carditis. The patient was diagnosed with active rheumatic fever (RF), systemic lupus erythematosus (SLE) and Antiphospholipid syndrome (APS). The combination of three unusual diagnoses in the same patient makes this a unique case, modifying patient treatment and prognosis.