EGBERTO REIS BARBOSA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
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article 4 Citação(ões) na Scopus Americo Negrette and Huntington's disease(2011) MOSCOVICH, Mariana; MUNHOZ, Renato P.; BECKER, Nilson; BARBOSA, Egberto Reis; ESPAY, Alberto J.; WEISER, Roberto; TEIVE, Hello A. G.The authors present a historical review of the seminal clinical contribution of Professor Americo Negrette, a Venezuelan neurologist, to the evolution of scientific knowledge about Huntington's disease.- Copper deficiency in Wilson's disease: An avoidable complication of treatment(2011) SILVA-JUNIOR, Francisco Pereira da; LUCATO, Leandro Tavares; MACHADO, Alexandre Aluizio Costa; BARBOSA, Egberto Reis
- ATP13A2-Related Neurodegeneration (PARK9) Without Evidence of Brain Iron Accumulation(2011) CHIEN, Hsin Fen; BONIFATI, Vincenzo; BARBOSA, Egberto Reis
article 3 Citação(ões) na Scopus Cross-cultural adaptation of the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) to Brazilian Portuguese(2011) SEKEFF-SALLEM, Flavio Augusto; CARAMELLI, Paulo; BARBOSA, Egberto ReisCervical dystonia (CD) is a prevalent and incapacitating movement disorder which needs a thorough clinical evaluation of every patient to better tailor treatment strategies. In Brazil, there are no validated CD scales that measure the burden of dystonia. The aim of our study was to translate and adapt the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) to Brazilian Portuguese. After translation and back-translation according to international methods, a pre-test was carried out with 30 patients. Patients under 8 years of formal schooling had severe difficulty in understanding the whole scale. The scale went through a remodeling process, without loss of its conceptual and semantic properties. The new scale was tested in 15 patients, with good understanding scores. We are now in the process of validation of the adapted scale.article 25 Citação(ões) na Scopus COPPER DEFICIENCY MYELONEUROPATHY IN A PATIENT WITH WILSON DISEASE(2011) SILVA-JUNIOR, F. P. da; MACHADO, A. A. C.; LUCATO, L. T.; CANCADO, E. L. R.; BARBOSA, E. R.article 14 Citação(ões) na Scopus Quality of life in individuals with cervical dystonia before botulinum toxin injection in a Brazilian tertiary care hospital(2011) QUEIROZ, Mariana Ribeiro; CHIEN, Hsin Fen; BARBOSA, Egberto ReisObjective: The purpose of this study was to evaluate quality of life (QoL) in a Brazilian population of individuals with cervical dystonia (CD) without effect of botulinum toxin (BTx) or with only residual effect of BTx, and identify possible physical and social aspects that affect their QoL. Method: Sixty five out of sixty seven consecutive patients with CD were assessed with two instruments: Short-form Health Survey with 36 questions (SF-36) and Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Results: Severity of CD (TWSTRS) correlated moderately with two SF-36 subscale: role-physical (r=-0.42) and body pain (r=-0.43). Women also scored worse in two subscale of SF-36: vitality (p<0.05) and mental-health (p<0.005). Conclusion: Severity of CD and gender (female) were the main factors related to a worse QoL perception. These findings may help health professionals to predict which characteristics could lead to worse QoL, and therefore, better target their interventions to lessen the burden caused by CD.- Wilson's disease in southern Brazil: a 40-year follow-up study(2011) BEM, Ricardo Schmitt de; MUZZILLO, Dominique Araujo; DEGUTI, Marta Mitiko; BARBOSA, Egberto Reis; WERNECK, Lineu Cesar; TEIVE, Helio Afonso GhizoniBACKGROUND: Long-term data on the clinical follow-up and the treatment effectiveness of Wilson's disease are limited because of the low disease frequency. This study evaluated a retrospective cohort of Wilson's disease patients from southern Brazil during a 40-year follow-up period. METHODS: Thirty-six Wilson's disease patients, diagnosed from 1971 to 2010, were retrospectively evaluated according to their clinical presentation, epidemiological and social features, response to therapy and outcome. RESULTS: Examining the patients' continental origins showed that 74.5% had a European ancestor. The mean age at the initial symptom presentation was 23.3 +/- 9.3 years, with a delay of 27.5 +/- 41.9 months until definitive diagnosis. At presentation, hepatic symptoms were predominant (38.9%), followed by mixed symptoms (hepatic and neuropsychiatric) (30.6%) and neuropsychiatric symptoms (25%). Kayser-Fleischer rings were identified in 55.6% of patients, with a higher frequency among those patients with neuropsychiatric symptoms (77.8%). Eighteen patients developed neuropsychiatric features, most commonly cerebellar syndrome. Neuroradiological imaging abnormalities were observed in 72.2% of these patients. Chronic liver disease was detected in 68% of the patients with hepatic symptoms. 94.2% of all the patients were treated with D-penicillamine for a mean time of 129.9 +/- 108.3 months. Other treatments included zinc salts, combined therapy and liver transplantation. After initiating therapy, 78.8% of the patients had a stable or improved outcome, and the overall survival rate was 90.1%. CONCLUSION: This study is the first retrospective description of a population of Wilson's disease patients of mainly European continental origin who live in southern Brazil. Wilson's disease is treatable if correctly diagnosed, and an adequate quality of life can be achieved, resulting in a long overall survival.