LUZIA NAOKO SHINOHARA FURUKAWA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Effect of an angiotensin II type 2 receptor agonist on myocardial hypertrophy and fibrosis induced by high salt diet(2017) DOPONA, Ellen Priscila Brito; ROCHA, Veronica Favoni; OLIVEIRA, Ivone Braga de; FURUKAWA, Luzia Naoko Shinohara; HEIMANN, Joel ClaudioconferenceObject Small litter size at birth is associated with insulin resistance and low energy expenditure in adulthood(2013) TAVARES, Neuziane Kloos Amorim; AGUIAR, Fernanda de Jesus; FURUKAWA, Luzia Naoko; HEIMANN, Joel ClaudioObjective: To evaluate the effect of litter size standardization at birth on adult metabolic parameters.Methods: Female Wistar rats became pregnant at 12 weeks of age. Offspring were divided into control(C), G8(8) and G4(4 newborns/litter) groups. At 12 weeks of age, food intake (FI,g/day), glucose (G,mg/dL), insulin (I,pM), cholesterol (Chol,mg/dL), triacylglycerols (TAG,mg/dL) levels, white and brown adipose tissue (BAT) masses (g/100g) adiposity index (AI,% body weight) were determined. Conclusion: Results suggest that changes in litter size is associated with energy balance, carbohydrate and lipid disorders, insulin resistance and alterations in blood pressure in adult male and female.conferenceObject Salt intake during pregnancy influences offspring organ growth(2014) PERES, Maria; OLIVEIRA, Ivone de; FURUKAWA, Luzia; GUIMARAES, Carina; HEIMANN, JoelconferenceObject Transgenerational Effects of High Salt Diet During Gestation(2016) PERES, Maria Angelica; OLIVEIRA, Ivone Braga de; FURUKAWA, Luzia Naoko Shinohara; HEIMANN, JoelconferenceObject Mitochondria function and structure in brown adipose tissue is influenced by maternal low salt intake during the perinatal period(2012) LOPES, Karen Lucasechi; SANTOS, Elisabete Alcantara Dos; FURUKAWA, Luzia Naoko Shinohara; HEIMANN, Joel ClaudioconferenceObject Glucose metabolism and DNA methylation of offspring are altered by maternal sodium restriction(2013) SIQUEIRA, Flavia Ramos; PhuongSon Nguyen; KOBZIK, Lester; OLIVEIRA, Ivone Braga de; HEIMANN, Joel Claudio; FURUKAWA, Luzia Naoko ShinoharaObjective: To evaluate glucose metabolism of adult offspring of dams fed low sodium diet during pregnancy. Methods: Female Wistar rats (n= 6 – 8/group) were fed low (LS- 0.15%) or normal (NS-1.3% NaCl) salt diet since the 1st day of gestation until delivery or LS during 1st (LS10) or 2 nd half of gestation (LS20). Body weight (BW), circulating glucose, insulin, leptin and C-peptide levels, glucose (GTT) and insulin tolerance test (ITT) and leptin receptor (LR) methylation were measured in male (M) and female (F) offspring at 12 weeks of age Results (mean±SEM, p< 0.05): BW, at birth (g, n=14 – 27/group) (M: NS = 6.5±0.1, LS = 5.5±0.1, LS10 = 6±0.1, LS20 = 4.8±0.1, F: NS = 6±0.2, LS = 5±0.1, LS10 = 6±0.1, LS20 = 4±0.1) was lower in LS, LS10 and LS20 than in NS, while at adulthood it was not different. Glucose was higher in LS (M=115±3; F=110±4) than in the other groups (M: NS=103±1; LS10=100±2; LS20=96±2; F:NS=101±2; LS10=100±2; 108±2). C-peptide was higher in LS (M=1117±152; F=509±27) than in NS (M=375±41; F=233±63) and lower in LS20 (M=97±15; F=76±9) compared to LS10 (M=528±112; F=378±45).Glucose was higher in LS M and F at 5 minutes of the GTT compared to NS offspring. Leptin, insulin, and ITT were not different. But LR methylation was increased in LS20. Conclusion: Sodium restriction during pregnancy leads to low birth weight and to modifications of glucose metabolism and LR methylation.conferenceObject Low sodium intake is associated with low birth weight and size only when given in the second half of gestation(2012) SIQUEIRA, Flavia Ramos de; SOUZA, Regiane Machado de; OLIVEIRA, Ivone Braga de; FURUKAWA, Luzia Naoko S.; HEIMANN, Joel ClaudioThis study examined the effects of maternal low sodium intake during different periods of pregnancy on dams and male (M) and female (F) offspring. Methods: Female Wistar rats (n= 6 - 8/group) were fed low (LS - 0.15%) or normal (NS - 1.3% NaCl) sodium diet since the 1st day of gestation until delivery or LS during the 1st (LS10) or 2nd half of gestation (LS20). Results: (mean±SEM, p< 0.05): Maternal body weight (g) was lower in LS and LS20 than in NS and LS10 at the 3rd week of gestation (LS = 380±8.1; LS20 = 406±13.2; NS = 435±6.1, LS10 = 461±12.9). No difference was found in water and food intake among the groups. Also, no differences were observed in the litter size among experimental groups and no correlation betweenthe number of pups and maternal body weight at the 3rd week of gestation. At birth, body weight (g, n=14 to 27/group) (M: NS = 6.5±0.1, LS = 5.5±0.1, LS10 = 6.1±0.1, LS20 =4.8±0.1,F:NS = 6.1±0.2, LS = 5.2±0.1, LS10 = 5.6±0.1, LS20 = 4.1±0.1) and naso-anal length (cm, n=14 to 27) (M: NS = 5.1±0.02, LS = 4.9±0.03, LS10 = 5.0±0.03, LS20 = 4.6±0.03, F: NS =4.9±0.05,LS = 4.8±0.04, LS10 = 4.9±0.03, LS20 = 4.4±0.03) were lower in LS and LS20 than in NS offspring. Conclusion: Although maternal dietary intake was not influenced by dietary sodium content, maternal low sodium diet during the second half of gestation induced lower birth weight and size.