PEDRO AUGUSTO ARAUJO MONTELEONE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject EVALUATION OF DUAL TRIGGER EFFICACY FOR FINAL OOCYTE MATURATION IN HIGH COMPLEXITY ASSISTED REPRODUCTION TECHNIQUES: A SYSTEMATIC REVIEW AND META-ANALISYS.(2020) DELAMUTA, Luciana Carvalho; LOBEL, Alexandre L. S.; MONTELEONE, Pedro A. A.; SOARES JR., Jose Maria; BARACAT, Edmund ChadabookPart Infertilidade Femina(2016) IZZO, Carlos Roberto; MONTELEONE, Pedro Augusto Araújo; SERAFINI, Paulo Cesar; BARACAT, Edmund Chada- Vitamin D and in vitro fertilization: a systematic review(2023) ELLER, Ana Berquo Peleja; EJZENBERG, Dani; MONTELEONE, Pedro Augusto Araujo; JR, Jose Maria Soares; BARACAT, Edmund ChadaPurposeVitamin D (VD) action on calcium is well known, but its other properties, particularly in the human reproductive system, are not completely understood. This review aims at assessing the relationship between serum VD levels and IVF results.MethodsA systematic review was carried out using MEDLINE, EMBASE, LILACS, Google scholar, the CAPES journal portal, and the Cochrane Library, as well as the descriptors ""vitamin D"" and ""fertilization in vitro."" The review was conducted by two authors following the PRISMA recommendations between September 2021 and February 2022.ResultsEighteen articles were selected. Five of them showed a positive correlation between serum VD levels and IVF results, 12 lacked any association, and 1 exhibited a negative correlation. The 3 studies that assessed VD in the follicular fluid found a positive correlation between the serum and follicular levels. Non-Hispanic White patients seemed to suffer the consequence of vitamin D deficiency more than Asian patients. In one study alone in the VD-deficient group, there was a larger number of natural killer (NK) cells, B cells, a greater proportion of helper T cells/cytotoxic T cells (Th/Tc), and an association with a smaller number of mature oocytes.ConclusionThe association between serum VD levels and the post-IVF pregnancy rate is uncertain. However, VD levels might be more relevant in the White than in the Asian ethnicity and in the number of aspiration follicles, and they could act in the immune system having an impact both on embryo implantation and on pregnancy.
- Granulosa cells and follicular development: a brief review ( vol 69 , e20230175 , 2023)(2023) CAVALCANTI, Giovanna Santos; CARVALHO, Katia Candido; FERREIRA, Cecilia da Silva; CHEDRAUI, Peter; MONTELEONE, Pedro Augusto Araujo; BARACAT, Edmund Chada; SOARES JUNIOR, Jose Maria
- One Plus One is Better than Two: An Approach Towards a Single Blastocyst Transfer Policy for All IVF Patients(2022) PEREGRINO, Pedro Felipe Magalhaes; BONETTI, Tatiana Carvalho de Souza; GOMES, Alecsandra Prado; MARTIN, Hamilton de; SOARES JUNIOR, Jose Maria; BARACAT, Edmund Chada; MONTELEONE, Pedro Augusto AraujoObjective It is known that the single embryo transfer (SET) is the best choice to reduce multiples and associated risks. The practice of cryopreserving all embryos for posterior transfer has been increasingly performed for in vitro fertilization (IVF) patients at the risk of ovarian hyperstimulation syndrome or preimplantation genetic testing for aneuploidy. However, its widespread practice is still controverse. The aim of this study was to evaluate how effective is the transfer of two sequential SET procedures compared with a double embryo transfer (DET) in freeze-only cycles. Methods This retrospective study reviewed 5,156 IVF cycles performed between 2011 and 2019, and 506 cycles using own oocytes and freeze-only policy with subsequent elective frozen-thawed embryo transfers (eFET) were selected for this study. Cycles having elective SET (eSET, n = 209) comprised our study group and as control group we included cycles performed with elective DET (eDET, n = 291). In the eSET group, 57 couples who had failed in the 1 (st) eSET had a 2 (nd) eFET, and the estimated cumulative ongoing pregnancy rate was calculated and compared with eDET. Results After the 1 (st) eFET, the ongoing pregnancy rates were similar between groups (eSET: 35.4% versus eDET: 38.5%; p = 0.497), but the estimated cumulative ongoing pregnancy rate after a 2 (nd) eFET in the eSET group (eSET + SET) was significantly higher (48.8%) than in the eDET group ( p < 0.001). Additionally, the eSET + SET group had a 2.7% rate of multiple gestations, which is significantly lower than the eDET group, with a 30.4% rate ( p < 0.001). Conclusion Our study showed the association of freeze-only strategy with until up to two consecutive frozen-thawed eSETs resulted in higher success rates than a frozen-thawed DET, while drastically reducing the rate of multiple pregnancies.
- Granulosa cells and follicular development: a brief review(2023) CAVALCANTI, Giovanna Santos; CARVALHO, Katia Candido; FERREIRA, Cecilia da Silva; ALVAREZ, Peter Andre Chedraui; MONTELEONE, Pedro Augusto Araujo; BARACAT, Edmund Chada; JR, Jose Maria Soares
bookPart Prognóstico reprodutivo de adolescentes com malformações Müllerianas(2021) MONTELEONE, Pedro Augusto Araújo; OLIVEIRA, Vanessa Heinrich Barbosa de; SERAFINI, Paulo Cesar; BARACAT, Edmund ChadabookPart Infertilidade feminina(2014) SERAFINI, Paulo; ROCHA, André Monteiro da; MONTELEONE, Pedro Augusto Araujo; BARACAT, Edmund ChadaconferenceObject SOCIODEMNIGRAPHIC AND ECONOMIC CHARACTERISTICS OF INFERTILE PATIENTS REFERRED TO A PUBLIC UNIVERSITY CENTER IN BRAZIL FOR ASSISTED REPRODUCTION THERAPY(2022) MAGALHAES, Bruna Lopes de; BELTRAMI, Natalia; PATATAS, Olivia; NAKANO, Mayra Satiko Lemos; EJZENBERG, Dani; MONTELEONE, Pedro AA.; BARACAT, Edmund Chada- Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review(2019) AMARAL, Maria Eduarda Bonavides; EJZENBERG, Dani; WAJMAN, Denis Schapira; MONTELEONE, Pedro Augusto Araujo; SERAFINI, Paulo; SOARES JR., Jose Maria; BARACAT, Edmund ChadaPurposeControlled ovarian stimulation is a fundamental part of a successful assisted reproduction treatment, and recognizing patients at risk of a poor response allows the development of targeted research to propose new treatment strategies for this specific group. The objective of this systematic review was to determine risk factors for poor ovarian response (POR) to controlled stimulation in assisted reproduction cycles described in the literature.MethodsThe primary databases MEDLINE, Cochrane, LILACS, and SciELO were consulted, using specific terms with a restriction for articles in English or Portuguese published in the last 10years.Results and conclusionOur data suggest that environmental endocrine disruptors, tobacco, genetic mutations, endometriomas, ovarian surgery, chemotherapy, and short menstrual cycles are factors that influence stimulation in assisted reproduction cycles. Further studies are necessary for characterizing patients with prior risk factors.