PEDRO AUGUSTO ARAUJO MONTELEONE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
13 resultados
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- Human reproduction: current status(2015) IZZO, Carlos Roberto; MONTELEONE, Pedro Augusto Araujo; SERAFINI, Paulo C.The concern about the maintenance of the human species has existed since the earliest civilizations. Progress in the diagnosis and treatment of infertility has led to the development of assisted reproductive techniques (ART) which, along with the evolution of genetics and molecular biology studies, have contributed in a concrete way to the management of infertile couples. Classic in vitro fertilization was initially developed 35 years ago for the treatment of women with tubal blockage, however, it remains inaccessible to a significant proportion of infertile couples around the world. This can be explained by the lack of specialized clinics in some countries and by the high cost of the procedures. Efforts have been employed to increase the number of treatment cycles for assisted reproduction, as for example, the creation of low-cost programs. Even today, infertility remains a problem of global proportions, affecting millions of couples. The estimate of the incidence of infertility is uncertain, mainly because of the criteria used for its definition. This article aims to review the most important aspects, succinctly, regarding the incidence, etiology, and treatment options available to infertile couples.
- Vitamin D and in vitro fertilization: a systematic review(2023) ELLER, Ana Berquo Peleja; EJZENBERG, Dani; MONTELEONE, Pedro Augusto Araujo; JR, Jose Maria Soares; BARACAT, Edmund ChadaPurposeVitamin D (VD) action on calcium is well known, but its other properties, particularly in the human reproductive system, are not completely understood. This review aims at assessing the relationship between serum VD levels and IVF results.MethodsA systematic review was carried out using MEDLINE, EMBASE, LILACS, Google scholar, the CAPES journal portal, and the Cochrane Library, as well as the descriptors ""vitamin D"" and ""fertilization in vitro."" The review was conducted by two authors following the PRISMA recommendations between September 2021 and February 2022.ResultsEighteen articles were selected. Five of them showed a positive correlation between serum VD levels and IVF results, 12 lacked any association, and 1 exhibited a negative correlation. The 3 studies that assessed VD in the follicular fluid found a positive correlation between the serum and follicular levels. Non-Hispanic White patients seemed to suffer the consequence of vitamin D deficiency more than Asian patients. In one study alone in the VD-deficient group, there was a larger number of natural killer (NK) cells, B cells, a greater proportion of helper T cells/cytotoxic T cells (Th/Tc), and an association with a smaller number of mature oocytes.ConclusionThe association between serum VD levels and the post-IVF pregnancy rate is uncertain. However, VD levels might be more relevant in the White than in the Asian ethnicity and in the number of aspiration follicles, and they could act in the immune system having an impact both on embryo implantation and on pregnancy.
- Correspondence: Interpreting live birth rates following preimplantation genetic testing for aneuploidy: per embryo transferred or initiated cycle*Re: ""Live birth per embryo transfer with next generation sequencing preimplantation genetic testing: an analysis of 26,107 cycles""(2023) MONTELEONE, Pedro Augusto Araujo; BONETTI, Tatiana Carvalho de Souza
- Granulosa cells and follicular development: a brief review ( vol 69 , e20230175 , 2023)(2023) CAVALCANTI, Giovanna Santos; CARVALHO, Katia Candido; FERREIRA, Cecilia da Silva; CHEDRAUI, Peter; MONTELEONE, Pedro Augusto Araujo; BARACAT, Edmund Chada; SOARES JUNIOR, Jose Maria
- Outcomes of elective cryopreserved single or double embryo transfers following failure to conceive after fresh single embryo transfer(2016) MONTELEONE, Pedro Augusto Araujo; MIRISOLA, R. J.; GONALVES, S. P.; BARACAT, Edmund C.; SERAFINI, Paulo C.The main adverse effect of IVF is the high multiple pregnancy rate resulting from the transfer of two or more embryos. The objective was to evaluate pregnancy rates in infertile women with a good prognosis who failed to conceive in a fresh elective single embryo transfer (eSET) and had a second cycle with elective double vitrified-warmed embryo transfer (eDFET) compared with elective single vitrified-warmed embryo transfer (eSFET). A total of 142 intracytoplasmic sperm injection cycles using a conventional protocol were evaluated. Good-prognosis patients underwent eSET in a fresh cycle, and those who failed to conceive underwent a second vitrified-warmed embryo transfer: eDFET (n = 102) or eSFET (n = 40). Embryos were transferred and vitrified on day 5 of development. Patients who received eDFET had fewer implantations (30.9%) than eSFET (52.5%; P = 0.004); pregnancy rates were similar (eDFET: 35.3%, eSFET: 42.5%). Patients with the eSFET had one monozygotic twin (5.9%), and 22.2% of eDFET patients had multiple pregnancies. Patients with a good prognosis who failed to conceive in the first fresh eSET did not have an advantage when receiving eDFET in the second cycle, as pregnancy rates were similar; 22.2% of patients in the eDFET group had multiple pregnancies.
- One Plus One is Better than Two: An Approach Towards a Single Blastocyst Transfer Policy for All IVF Patients(2022) PEREGRINO, Pedro Felipe Magalhaes; BONETTI, Tatiana Carvalho de Souza; GOMES, Alecsandra Prado; MARTIN, Hamilton de; SOARES JUNIOR, Jose Maria; BARACAT, Edmund Chada; MONTELEONE, Pedro Augusto AraujoObjective It is known that the single embryo transfer (SET) is the best choice to reduce multiples and associated risks. The practice of cryopreserving all embryos for posterior transfer has been increasingly performed for in vitro fertilization (IVF) patients at the risk of ovarian hyperstimulation syndrome or preimplantation genetic testing for aneuploidy. However, its widespread practice is still controverse. The aim of this study was to evaluate how effective is the transfer of two sequential SET procedures compared with a double embryo transfer (DET) in freeze-only cycles. Methods This retrospective study reviewed 5,156 IVF cycles performed between 2011 and 2019, and 506 cycles using own oocytes and freeze-only policy with subsequent elective frozen-thawed embryo transfers (eFET) were selected for this study. Cycles having elective SET (eSET, n = 209) comprised our study group and as control group we included cycles performed with elective DET (eDET, n = 291). In the eSET group, 57 couples who had failed in the 1 (st) eSET had a 2 (nd) eFET, and the estimated cumulative ongoing pregnancy rate was calculated and compared with eDET. Results After the 1 (st) eFET, the ongoing pregnancy rates were similar between groups (eSET: 35.4% versus eDET: 38.5%; p = 0.497), but the estimated cumulative ongoing pregnancy rate after a 2 (nd) eFET in the eSET group (eSET + SET) was significantly higher (48.8%) than in the eDET group ( p < 0.001). Additionally, the eSET + SET group had a 2.7% rate of multiple gestations, which is significantly lower than the eDET group, with a 30.4% rate ( p < 0.001). Conclusion Our study showed the association of freeze-only strategy with until up to two consecutive frozen-thawed eSETs resulted in higher success rates than a frozen-thawed DET, while drastically reducing the rate of multiple pregnancies.
- Granulosa cells and follicular development: a brief review(2023) CAVALCANTI, Giovanna Santos; CARVALHO, Katia Candido; FERREIRA, Cecilia da Silva; ALVAREZ, Peter Andre Chedraui; MONTELEONE, Pedro Augusto Araujo; BARACAT, Edmund Chada; JR, Jose Maria Soares
bookPart Infertilidade por fator uterino(2016) KRöGER, Gustavo Burcovschi; EJZENBERG, Dani; MONTELEONE, Pedro Augusto Araujo; SERAFINI, Paulo CésarbookPart Endometriose e infertilidade(2016) BIANCHI, Paulo Homem de Mello; MONTELEONE, Pedro Augusto Araujo; SERAFINI, Paulo CésarbookPart Infertilidade feminina(2014) SERAFINI, Paulo; ROCHA, André Monteiro da; MONTELEONE, Pedro Augusto Araujo; BARACAT, Edmund Chada