PEDRO AUGUSTO ARAUJO MONTELEONE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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- Vitamin D and in vitro fertilization: a systematic review(2023) ELLER, Ana Berquo Peleja; EJZENBERG, Dani; MONTELEONE, Pedro Augusto Araujo; JR, Jose Maria Soares; BARACAT, Edmund ChadaPurposeVitamin D (VD) action on calcium is well known, but its other properties, particularly in the human reproductive system, are not completely understood. This review aims at assessing the relationship between serum VD levels and IVF results.MethodsA systematic review was carried out using MEDLINE, EMBASE, LILACS, Google scholar, the CAPES journal portal, and the Cochrane Library, as well as the descriptors ""vitamin D"" and ""fertilization in vitro."" The review was conducted by two authors following the PRISMA recommendations between September 2021 and February 2022.ResultsEighteen articles were selected. Five of them showed a positive correlation between serum VD levels and IVF results, 12 lacked any association, and 1 exhibited a negative correlation. The 3 studies that assessed VD in the follicular fluid found a positive correlation between the serum and follicular levels. Non-Hispanic White patients seemed to suffer the consequence of vitamin D deficiency more than Asian patients. In one study alone in the VD-deficient group, there was a larger number of natural killer (NK) cells, B cells, a greater proportion of helper T cells/cytotoxic T cells (Th/Tc), and an association with a smaller number of mature oocytes.ConclusionThe association between serum VD levels and the post-IVF pregnancy rate is uncertain. However, VD levels might be more relevant in the White than in the Asian ethnicity and in the number of aspiration follicles, and they could act in the immune system having an impact both on embryo implantation and on pregnancy.
conferenceObject Women's age is the best success predictor in a cohort of poor responders: A retrospective analysis according to POSEIDON criteria(2022) AMARAL, M. E.; MONTELEONE, P. A. A.; EJZENBERG, D.; BARACAT, E. C.- Prognostic factors for pregnancy after intrauterine insemination(2019) EJZENBERG, Dani; GOMES, Tiago J. O.; MONTELEONE, Pedro A. A.; SERAFINI, Paulo C.; SOARES- JR., Jose M.; BARACAT, Edmund C.Objective To evaluate prognostic factors for pregnancy after intrauterine insemination (IUI). Methods A retrospective study was conducted among couples who underwent IUI at Universidade de Sao Paulo, Brazil, between January 31, 2008, and April 30, 2016. The main outcome was a positive beta human chorionic gonadotropin (beta-hCG) test result after IUI. Univariate analyses were used to determine predictors of pregnancy. Selected numerical variables were categorized to maximize the area under the receiver operating characteristic (ROC) curve. Logistic regression was performed using the backward method. The quality of the model was evaluated using the R-2 (Nagelkerke) and Hosmer-Lemeshow tests. Results Of 355 insemination cycles, 56 (15.8%) resulted in a positive beta-hCG test result. The predictors and cutoff values that maximized the area under the ROC curve were as follows: follicle-stimulating hormone (mIU/mL; P<0.001); duration of infertility (P<0.001); number of follicles greater than or equal to 14 mm (>1 follicle; P<0.001); baseline spermatozoa concentration (>52.0 million/mL; P=0.007); total ejaculate (>123.7 million; P=0.003); and grade B motility (>35%; P=0.013). These factors were able to predict 50.4% of the positive test results (R-2). Conclusion Prognostic factors for pregnancy identified approximately half of all successful outcomes after IUI.
bookPart Infertilidade por fator uterino(2016) KRöGER, Gustavo Burcovschi; EJZENBERG, Dani; MONTELEONE, Pedro Augusto Araujo; SERAFINI, Paulo CésarconferenceObject SOCIODEMNIGRAPHIC AND ECONOMIC CHARACTERISTICS OF INFERTILE PATIENTS REFERRED TO A PUBLIC UNIVERSITY CENTER IN BRAZIL FOR ASSISTED REPRODUCTION THERAPY(2022) MAGALHAES, Bruna Lopes de; BELTRAMI, Natalia; PATATAS, Olivia; NAKANO, Mayra Satiko Lemos; EJZENBERG, Dani; MONTELEONE, Pedro AA.; BARACAT, Edmund Chada- Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review(2019) AMARAL, Maria Eduarda Bonavides; EJZENBERG, Dani; WAJMAN, Denis Schapira; MONTELEONE, Pedro Augusto Araujo; SERAFINI, Paulo; SOARES JR., Jose Maria; BARACAT, Edmund ChadaPurposeControlled ovarian stimulation is a fundamental part of a successful assisted reproduction treatment, and recognizing patients at risk of a poor response allows the development of targeted research to propose new treatment strategies for this specific group. The objective of this systematic review was to determine risk factors for poor ovarian response (POR) to controlled stimulation in assisted reproduction cycles described in the literature.MethodsThe primary databases MEDLINE, Cochrane, LILACS, and SciELO were consulted, using specific terms with a restriction for articles in English or Portuguese published in the last 10years.Results and conclusionOur data suggest that environmental endocrine disruptors, tobacco, genetic mutations, endometriomas, ovarian surgery, chemotherapy, and short menstrual cycles are factors that influence stimulation in assisted reproduction cycles. Further studies are necessary for characterizing patients with prior risk factors.