ANTONIO CARLOS LOPES
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
35 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 35
- Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder(2021) SHEPHARD, Elizabeth; STERN, Emily R.; HEUVEL, Odile A. van den; COSTA, Daniel L. C.; BATISTUZZO, Marcelo C.; GODOY, Priscilla B. G.; LOPES, Antonio C.; BRUNONI, Andre R.; HOEXTER, Marcelo Q.; SHAVITT, Roseli G.; REDDY, Y. C. Janardhan; LOCHNER, Christine; STEIN, Dan J.; SIMPSON, H. Blair; MIGUEL, Euripedes C.An important challenge in mental health research is to translate findings from cognitive neuroscience and neuroimaging research into effective treatments that target the neurobiological alterations involved in psychiatric symptoms. To address this challenge, in this review we propose a heuristic neurocircuit-based taxonomy to guide the treatment of obsessive-compulsive disorder (OCD). We do this by integrating information from several sources. First, we provide case vignettes in which patients with OCD describe their symptoms and discuss different clinical profiles in the phenotypic expression of the condition. Second, we link variations in these clinical profiles to underlying neurocircuit dysfunctions, drawing on findings from neuropsychological and neuroimaging studies in OCD. Third, we consider behavioral, pharmacological, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions. Finally, we suggest methods of testing this neurocircuit-based taxonomy as well as important limitations to this approach that should be considered in future research.
conferenceObject Associations Between Medial Prefrontal Cerebral Metabolic Features and Clinical Characteristics in Obsessive-compulsive Disorder(2016) BATISTUZZO, Marcelo C.; HOEXTER, Marcelo; COSTA, Fabiana; SHAVITT, Roseli; LOPES, Antonio C.; CAPPI, Carolina; VATTIMO, Edoardo; MATHIS, Alice de; DINIZ, Juliana B.; HENNING, Anke; PASTORELLO, Bruno; MIGUEL, Euripedes C.; OTADUY, Maria C.conferenceObject Lateral Insertion of Leads and Treatment Outcomes in Ventral Capsule/Ventral Striatum Deep Brain Stimulation for Obsessive-Compulsive Disorder(2020) LOPES, Antonio; GODINHO, Fabio; MURAKAMI, Mario; IGLESIO, Ricardo; LEEMANS, Alexander; FONOFF, Erich; MIGUEL, Euripedes; TEIXEIRA, Manoel; ARANTES, Paula- Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial (vol 71, pg 1066, 2014)(2016) LOPES, A. C.; GREENBERG, B. D.; CANTERAS, M. M.
- Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive-compulsive disorder(2013) HOEXTER, Marcelo Q.; DOUGHERTY, Darin D.; SHAVITT, Roseli G.; D'ALCANTE, Carina C.; DURAN, Fabio L. S.; LOPES, Antonio C.; DINIZ, Juliana B.; BATISTUZZO, Marcelo C.; EVANS, Karleyton C.; BRESSAN, Rodrigo A.; BUSATTO, Geraldo F.; MIGUEL, Euripedes C.Nearly one-third of patients with obsessive-compulsive disorder (OCD) fail to respond to adequate therapeutic approaches such as serotonin reuptake inhibitors and/or cognitive-behavioral therapy (CBT). This study investigated structural magnetic resonance imaging (MRI) correlates as potential pre-treatment brain markers to predict treatment response in treatment-naive OCD patients randomized between trials of fluoxetine or CBI Treatment-naive OCD patients underwent structural MRI scans before randomization to a 12-week clinical trial of either fluoxetine or group-based CBT. Voxel-based morphometry was used to identify correlations between pretreatment regional gray matter volume and changes in symptom severity on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Brain regional correlations of treatment response differed between treatment groups. Notably, symptom improvement in the fluoxetine treatment group (n=14) was significantly correlated with smaller pretreatment gray matter volume within the right middle lateral orbitofrontal cortex (OFC), whereas symptom improvement in the CBT treatment group (n=15) was significantly correlated with larger pretreatment gray matter volume within the right medial prefrontal cortex (mPFC). No significant a priori regional correlations of treatment response were identified as common between the two treatment groups when considering the entire sample (n=29). These findings suggest that pretreatment gray matter volumes of distinct brain regions within the lateral OFC and mPFC were differentially correlated to treatment response to fluoxetine versus CBT in OCD patients. This study further implicates the mPFC in the fear/anxiety extinction process and stresses the importance of lateral portions of the OFC in mediating fluoxetine's effectiveness in OCD. Clinical registration information: http://clinicaltrials.gov-NCT00680602.
conferenceObject Decrease in Thalamic Volumes of Refractory Patients with Obsessive-Compulsive Disorder who Were Submitted to Gamma Ventral Capsulotomy(2015) COSTA, Douglas; BATISTUZZO, Marcelo; DURAN, Fabio; GREENBERG, Benjamin; CANTERAS, Miguel; SHAVITT, Roseli; GENTIL, Andre; MIGUEL, Euripedes; LOPES, Antonio; HOEXTER, MarceloconferenceObject Single-Shot Gamma Ventral Capsulotomy for Obsessive Compulsive Disorder and Insufficient Response to Radiosurgery(2018) LOPES, Antonio; KASABKOJIAN, Stephanie; SALLES, Antonio de; GORGULHO, Alessandra; VATTIMO, Edoardo; BATISTUZZO, Marcelo; HOEXTER, Marcelo; MATHIS, Maria E. de; JOAQUIM, Marines; CAPPI, Carolina; MCLAUGHLIN, Nicole; GREENBERG, Benjamin; NOREN, Georg; MIGUEL, Euripedes- Effects of Providing Additional Lesions to Single-Shot Gamma Ventral Capsulotomy for Obsessive Compulsive Disorder(2019) LOPES, Antonio; KASABKOJIAN, Stephanie; SALLES, Antonio de; GORGULHO, Alessandra; BATISTUZZO, Marcelo; HOEXTER, Marcelo; JOAQUIM, Marines; COPETTI, Maria; MCLAUGHLIN, Nicole; GREENBERG, Benjamin; NOREN, Georg; MIGUEL, Euripedes
conferenceObject Structural connectivity associated with effective capsulotomy lesion volumes for refractory OCD(2018) NANDA, Pranav; BANKS, Garrett; PATHAK, Yagna; HOEXTER, Marcelo; LOPES, Antonio; GREENBERG, Benjamin; RASMUSSEN, Steven; SHEEHAN, Jason; MIGUEL, Euripedes; FOX, Michael; MCLAUGHLIN, Nicole; SHETH, SameerconferenceObject Spatial Normalization Discrepancies Between Native and MNI152 Brain Template Scans in Gamma Ventral Capsulotomy Patients(2023) GIFF, Alexis; NOREN, Georg; MAGNOTTI, John; LOPES, Antonio Carlos; BATISTUZZO, Marcelo; HOEXTER, Marcelo; GREENBERG, Benjamin; MARSLAND, Richard; MIGUEL, Euripedes; RASMUSSEN, Steven; MCLAUGHLIN, Nicole