ANTONIO CARLOS LOPES

(Fonte: Lattes)
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Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: Neuropsychopharmacology ×

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    Decrease in Thalamic Volumes of Refractory Patients with Obsessive-Compulsive Disorder who Were Submitted to Gamma Ventral Capsulotomy
    (2015) COSTA, Douglas; BATISTUZZO, Marcelo; DURAN, Fabio; GREENBERG, Benjamin; CANTERAS, Miguel; SHAVITT, Roseli; GENTIL, Andre; MIGUEL, Euripedes; LOPES, Antonio; HOEXTER, Marcelo
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    Myo-Inositol Reduction in Medial Prefrontal Cortex of Obsessive Compulsive Disorder: A Proton Magnetic Resonance Spectroscopy Study
    (2015) BATISTUZZO, Marcelo; HOEXTER, Marcelo; COSTA, Fabiana; SHAVITT, Roseli; LOPES, Antonio; CAPPI, Carolina; MATHIS, Alice De; NATASHA, Senc O.; HENNING, Anke; PASTORELLO, Bruno; LEITE, Claudia; MIGUEL, Euripedes; OTADUY, Maria
  • article 29 Citação(ões) na Scopus
    Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive-Compulsive Disorder Patients
    (2015) BATISTUZZO, Marcelo C.; HOEXTER, Marcelo Q.; TAUB, Anita; GENTIL, Andre F.; CESAR, Raony C. C.; JOAQUIM, Marines A.; D'ALCANTE, Carina Chaubet; MCLAUGHLIN, Nicole C.; CANTERAS, Miguel M.; SHAVITT, Roseli G.; SAVAGE, Cary R.; GREENBERG, Benjamin D.; NOREN, Georg; MIGUEL, Euripedes C.; LOPES, Antonio C.
    Gamma ventral capsulotomy (GVC) radiosurgery is intended to minimize side effects while maintaining the efficacy of traditional thermocoagulation techniques for the treatment of refractory obsessive-compulsive disorder (OCD). Neuropsychological outcomes are not clear based on previous studies and, therefore, we investigated the effects of GVC on cognitive and motor performance. A double-blind, randomized controlled trial (RCT) was conducted with 16 refractory OCD patients allocated to active treatment (n = 8) and sham (n = 8) groups. A comprehensive neuropsychological evaluation including intellectual functioning, attention, verbal and visuospatial learning and memory, visuospatial perception, inhibitory control, cognitive flexibility, and motor functioning was applied at baseline and one year after the procedure. Secondary analysis included all operated patients: eight from the active group, four from the sham group who were submitted to surgery after blind was broken, and five patients from a previous open pilot study (n = 5), totaling 17 patients. In the RCT, visuospatial memory (VSM) performance significantly improved in the active group after GVC (p = 0.008), and remained stable in the sham group. Considering all patients operated, there was no decline in cognitive or motor functioning after one year of follow-up. Our initial results after 1 year of follow-up suggests that GVC not only is a safe procedure in terms of neuropsychological functioning but in fact may actually improve certain neuropsychological domains, particularly VSM performance, in treatment refractory OCD patients.
  • article 106 Citação(ões) na Scopus
    Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial
    (2012) HOEXTER, Marcelo Queiroz; DURAN, Fabio Luis de Souza; D'ALCANTE, Carina Chaubet; DOUGHERTY, Darin Dean; SHAVITT, Roseli Gedanke; LOPES, Antonio Carlos; DINIZ, Juliana Belo; DECKERSBACH, Thilo; BATISTUZZO, Marcelo Camargo; BRESSAN, Rodrigo Affonseca; MIGUEL, Euripedes Constantino; BUSATTO, Geraldo Filho
    Serotonin reuptake inhibitors and cognitive-behavior therapy (CBT) are considered first-line treatments for obsessive-compulsive disorder (OCD). However, little is known about their modulatory effects on regional brain morphology in OCD patients. We sought to document structural brain abnormalities in treatment-naive OCD patients and to determine the effects of pharmacological and cognitive-behavioral treatments on regional brain volumes. Treatment-naive patients with OCD (n = 38) underwent structural magnetic resonance imaging scan before and after a 12-week randomized clinical trial with either fluoxetine or group CBT. Matched-healthy controls (n = 36) were also scanned at baseline. Voxel-based morphometry was used to compare regional gray matter (GM) volumes of regions of interest (ROIs) placed in the orbitofrontal, anterior cingulate and temporolimbic cortices, striatum, and thalamus. Treatment-naive OCD patients presented smaller GM volume in the left putamen, bilateral medial orbitofrontal, and left anterior cingulate cortices than did controls (p<0.05, corrected for multiple comparisons). After treatment with either fluoxetine or CBT (n = 26), GM volume abnormalities in the left putamen were no longer detectable relative to controls. ROI-based within-group comparisons revealed that GM volume in the left putamen significantly increased (p<0.012) in fluoxetine-treated patients (n = 13), whereas no significant GM volume changes were observed in CBT-treated patients (n = 13). This study supports the involvement of orbitofronto/cingulo-striatal loops in the pathophysiology of OCD and suggests that fluoxetine and CBT may have distinct neurobiological mechanisms of action. Neuropsychopharmacology (2012) 37, 734-745; doi: 10.1038/npp.2011.250; published online 26 October 2011