VERA HERMINA KALIKA KOCH

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Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina - Líder

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Revista / Livro: Pediatric Nephrology ×

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  • conferenceObject
    Pediatric peritoneal dialysis in Brazil: document by the Brazilian Society of Nephrology, Brazilian Society of Pediatrics, Brazilian Association of Organ Transplantation, and the Brazilian Association of Dialysis and Transplant Centers.
    (2023) PENIDO, Maria Goretti Moreira Guimaraes; PALMA, Lilian Monteiro Pereira; BRESOLIN, Nilzete Liberato; TAVARES, Marcelo Sousa; SYLVESTRE, Lucimary Castro; ANDRADE, Olberes Vitor Braga de; BERNARDES, Rejane Paula; BANDEIRA, Maria de Fatima Santos; GARCIA, Clotilde Druck; KOCH, Vera Hermina Kalika; BELANGERO, Vera Maria Santoro; UHLMANN, Anelise; KAUFMAN, Arnauld; ANDRADE, Maria Cristina; SILVA, Roxana Almeida Roque Fontes
  • article 9 Citação(ões) na Scopus
    First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction
    (2019) KOSTIC, Dusan; BEOZZO, Glenda Priscila Neves dos Santos; COUTO, Saulo Brasil do; KATO, Andre Henrique Teruaki; LIMA, Laila; PALMEIRA, Patricia; KREBS, Vera Lucia Jornada; BUNDUKI, Victor; FRANCISCO, Rossana Pulcineli Vieira; ZUGAIB, Marcelo; CARVALHO, Werther Brunow de; KOCH, Vera Hermina Kalika
    Background Diagnosis of renal function impairment and deterioration in congenital urinary tract obstruction (UTO) continues to be extremely challenging. Use of renal biomarkers in this setting may favor early renal injury detection, allowing for a reliable choice of optimal therapeutic options and prevention or minimization of definitive renal damage. Methods This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-beta 1), retinol-binding protein (RBP), cystatin C (mu CyC), and microalbuminuria (ALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. Results All urine biomarkers showed significantly higher values at the first month of life (p <= 0.009), while NGAL (p = 0.005), TGF-beta 1 (p<0.001), and mu ALB (p<0.001) were high since birth compared to controls. Best single biomarker performances were RBP in bilateral hydronephrosis and LUTO subgroups and KIM-1 in unilateral hydronephrosis subgroup. Best biomarker combination results for all subgroups were obtained by matching RBP with TGF-beta 1 or KIM-1 and NGAL with CyC ([AUC] <= 0.934; sensitivity <= 92.4%; specificity <= 92.8%). Conclusions RBP, NGAL, KIM-1, TGF-beta 1, and CyC, alone and especially in combination, are relatively efficient in identifying surgically amenable congenital UTO and could be of practical use in indicating on-time surgery.
  • conferenceObject
    IPEX syndrome with Dent's disease manifestations - Case Report
    (2013) KOSTIC, Dusan; BRASIL, Saulo Couto; JACOB, Cristina Miuki Abe; SAMPAIO, Magda Carneiro; KOCH, Vera Hermina Kalika
    Objective: IPEX syndrome, a hereditary (X-linked) immune dysregulation with autoimmune polyendocrinopathy and enteropathy, as the basic manifestations, presents a rare and severe disease. The objective of this case report is to highlight the pleomorphism of the syndrome. Methods: The authors report the case of a male infant, with a family history of three male siblings affected by IPEX syndrome. The patients’ medical records were reviewed in order to describe the case of the youngest one. Results: During the follow-up of the youngest of three siblings, who presented eczema and intestinal manifestation, without compromised pancreatic and thyroid function, different from other two siblings, it was noticed the pattern of Dent’s disease. We registered hypophosphatemia, hypercalciuria, glycosuria, low molecular weight proteinuria and ultrasound revealed second stage bilateral nephrocalcinosis. In this child there was no apparent glomerular involvement, as it was seen in the eldest sibling. Conclusion: Dent’s disease is an X-linked renal proximal tubulopathy associated with mutations in the chloride channel gene CLCN5 (Xp11.22), which is next to FOXP3 gene on the X chromosome (Xp11.23-q13.3). It seems that in this sibling mutations occurred inexons of both of these genes. This case is to remind on pleomorphic potential of mutations that occur near the coding regions of the FOXP3 gene.
  • conferenceObject
    Quality of life of patients with MNE and the perception of their caregivers
    (2016) FAGUNDES, S. N.; LEBL, A. S.; SOSTER, L. M.; KOCH, V. H.
  • conferenceObject
    The postural alignment in enuretic children and teenagers
    (2013) PEREIRA, Rita Pavione Rodrigues; KOCH, Vera HerminaKalika; FAGUNDES, Simone Nascimento; KARIYA, Larissa Tiaki; ARAJO, Talita Souza de; SAKIMA, Thaisa Mayumi; TANAKA, Clarice
  • article 35 Citação(ões) na Scopus
    Health-related quality of life of children and adolescents with CKD stages 4-5 and their caregivers
    (2014) LOPES, Marcos; FERRARO, Alexandre; KOCH, Vera H.
    Renal replacement therapies may affect the quality of life of patients and their primary caregivers (PC). This study describes the perception of health-related quality of life (HRQoL) of children/adolescents with CKD stages 4-5, as well as of their PC (n = 64), in comparison to healthy peers and their PC (n = 129), respectively, based on the Peds QL (TM) 4.0 and Short Form-36 (SF-36) questionnaires and selected biomarkers. Patients reported a deleterious impact on physical capacity and on social and school activities. A negative influence on emotional aspects was reported by older patients, but not by their PC. Hemodialysis, followed by peritoneal dialysis, had a more negative impact on patients' physical functioning domain. PC HRQol proxy reports differed from those of their children, especially in older patients. PC of both groups presented similar SF-36 scores. An association was demonstrated between the magnitude of treatment target inadequacies, lower specific dominion scores in the patients/PC proxy reports and PC SF-36 general health scores. The HRQoL of patients with CKD stages 4-5 is negatively affected to different degrees depending on age and treatment modality. The results suggest an association between worsening HRQoL parameters and inadequate control of recognized therapeutic CKD treatment targets.
  • conferenceObject
    COLLABORATIVE BRAZILIAN PEDIATRIC RENAL TRANSPLANT REGISTRY (COBRAZPED-RTX): A REPORT FROM 2004-2014
    (2015) GARCIA, Clotilde; PESTANA, Jose Medina; MARTINS, Suelen; NOGUEIRA, Paulo; BITTENCOURT, Viviane; ROHDE, Roberta; CAMARGO, Maria; CAMARGO, Maria; FELTRAN, Luciana; ESMERALDO, Ronaldo; CARVALHO, Rebeca; SCHVARTSMAN, Benita; VAISBICH, Maria; KOCH, Vera; WATANABE, Andrea; CUNHA, Mariana; MENESES, Rejane; PRATES, Liliane; BELANGERO, Vera; PALMA, Lilian; CARVALHO, Deise; MATUK, Teresa; BENINI, Vanda; LARANJO, Simone; ABBUD FILHO, Mario; FERNANDES, Ida; RAMALHO, Horacio; LIMA, Eleonora; PENIDO, Jose; ANDRADE, Claudia; GESTEIRA, Maria; TAVARES, Marcelo; PENIDO, Mariana; SOUZA, Vandrea De; WAGNER, Mario
  • conferenceObject
    The hip and spine mobility is diminished in enuretic children and teenagers
    (2013) PEREIRA, Rita Pavione Rodrigues; KOCH, Vera Herminakalika; GONCALVES, Monica Maria Ribeiro; MILHORATTI, Thais de Souza; PACHECO, Daniela Castro; TANAKA, Clarice
  • conferenceObject
    PATIENTS WITH ENURESIS MAY HAVE BALANCE DISORDERS
    (2015) PAVIONE, Rita; PEREIRA, Rodrigues; MACHADO, Marcos Giannetti; FAGUNDES, Simone Nascimento; LEBL, Adriene; AZEVEDO, Leticia; KOCK, Vera Hermina; TANAKA, Clarice
  • conferenceObject
    POSTURE AND MOBILITY CHANGES IN PATIENTS WITH NOCTURNAL ENURESIS
    (2015) PEREIRA, Rita Pavione Rodrigues; MACHADO, Marcos Giannetti; FAGUNDES, Simone Nascimento; LEBL, Adriene; AZEVEDO, Leticia; KOCK, Vera Hermina; TANAKA, Clarice