BRYAN SAUNDERS
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
conferenceObject Optimising Sodium Bicarbonate Supplementation: Are Gastro-resistant Capsules The Answer?(2018) OLIVEIRA, Luana F.; SAUNDERS, Bryan; YAMAGUCHI, Guilherme; GUALANO, Bruno; ROSCHEL, Hamilton; ARTIOLI, Guilherme G.conferenceObject Chronic (24 weeks) Beta-alanine Supplementation Does Not Affect Muscle Taurine Or Blood Clinical Chemistry(2018) SAUNDERS, Bryan; FRANCHI, Mariana; OLIVEIRA, Luana F.; PAINELLI, Vitor S.; SILVA, Vinicius E.; SILVA, Rafael P.; COSTA, Luiz A. R.; SALE, Craig; HARRIS, Roger C.; ROSCHEL, Hamilton; ARTIOLI, Guilherme G.; GUALANO, BrunoconferenceObject Beta-Alanine Did Not Improve High-Intensity Performance Throughout Simulated Road Cycling(2021) PERIM, Pedro; GOBBI, Nathan; DUARTE, Breno; OLIVEIRA, Luana Faria de; COSTA, Luiz Augusto Riani; SALE, Craig; GUALANO, Bruno; DOLAN, Eimear; SAUNDERS, BryanconferenceObject Sex, But Not Age, Associates With Whole Muscle Carnosine Content Of Trained Men And Women(2020) DOLAN, Eimear; SWINTON, Paul A.; OLIVEIRA, Luana Farias de; REZENDE, Nathalia Saffioti; MAZZOLANI, Bruna Caruso; BESTETTI, Giulia Cazetta; SMAIRA, Fabiana Infante; DUMAS, Alina; PERIM, Pedro; RIANI, Luiz; GUALANO, Bruno; SAUNDERS, Bryan- High-Intensity Interval Training Augments Muscle Carnosine in the Absence of Dietary Beta-alanine Intake(2018) PAINELLI, Vitor De Salles; NEMEZIO, Kleiner Marcio; PINTO, Ana Jessica; FRANCHI, Mariana; ANDRADE, Isabel; RIANI, Luiz Augusto; SAUNDERS, Bryan; SALE, Craig; HARRIS, Roger Charles; GUALANO, Bruno; ARTIOLI, Guilherme GianniniPurpose Cross-sectional studies suggest that training can increase muscle carnosine (MCarn), although longitudinal studies have failed to confirm this. A lack of control for dietary -alanine intake or muscle fiber type shifting may have hampered their conclusions. The purpose of the present study was to investigate the effects of high-intensity interval training (HIIT) on MCarn. Methods Twenty vegetarian men were randomly assigned to a control (CON) (n = 10) or HIIT (n = 10) group. High-intensity interval training was performed on a cycle ergometer for 12 wk, with progressive volume (6-12 series) and intensity (140%-170% lactate threshold [LT]). Muscle carnosine was quantified in whole-muscle and individual fibers; expression of selected genes (CARNS, CNDP2, ABAT, TauT, and PAT1) and muscle buffering capacity in vitro (m(in vitro)) were also determined. Exercise tests were performed to evaluate total work done, VO2max, ventilatory thresholds (VT) and LT. Results Total work done, VT, LT, VO2max, and m(in vitro) were improved in the HIIT group (all P < 0.05), but not in CON (P > 0.05). MCarn (in mmolkg(-1) dry muscle) increased in the HIIT (15.8 5.7 to 20.6 +/- 5.3; P = 0.012) but not the CON group (14.3 +/- 5.3 to 15.0 +/- 4.9; P = 0.99). In type I fibers, MCarn increased in the HIIT (from 14.4 +/- 5.9 to 16.8 +/- 7.6; P = 0.047) but not the CON group (from 14.0 +/- 5.5 to 14.9 +/- 5.4; P = 0.99). In type IIa fibers, MCarn increased in the HIIT group (from 18.8 +/- 6.1 to 20.5 +/- 6.4; P = 0.067) but not the CON group (from 19.7 +/- 4.5 to 18.8 +/- 4.4; P = 0.37). No changes in gene expression were shown. Conclusions In the absence of any dietary intake of -alanine, HIIT increased MCarn content. The contribution of increased MCarn to the total increase in m(in vitro) appears to be small.
- Nonplacebo Controls to Determine the Magnitude of Ergogenic Interventions: A Systematic Review and Meta-analysis(2021) MARTICORENA, Felipe Miguel; CARVALHO, Arthur; OLIVEIRA, Luana Farias de; DOLAN, Eimear; GUALANO, Bruno; SWINTON, Paul; SAUNDERS, BryanIntroduction Placebos are used as a control treatment that is meant to be indistinguishable from the active intervention. However, where substantive placebo effects may occur, studies that do not include a nonplacebo control arm may underestimate the overall effect of the intervention (active plus placebo components). This study aimed to determine the relative magnitude of the placebo effect associated with nutritional supplements (caffeine and extracellular buffers) by meta-analyzing data from studies containing both placebo and nonplacebo control sessions. Methods Bayesian multilevel meta-analysis models were used to estimate pooled effects and express the placebo effect as a percentage of the overall intervention effect. Results Thirty-four studies were included, with the median pooled effect size (ES0.5) indicating a very small (ES0.5 = 0.09 (95% credible interval (CrI), 0.01-0.17)) improvement in the performance of placebo compared with control. There was no moderating effect of exercise type (capacity or performance), exercise duration, or training status. The comparison between active intervention and control indicated a small to medium effect (ES0.5 = 0.37 (95% CrI, 0.20-0.56)). Expressed in relative terms, the placebo effect was equivalent to 25% (75% CrI, 16%-35%) and 59% (75% CrI, 34%-94%) of the total intervention effect for buffers and caffeine. Conclusions These results demonstrate a very small but potentially important placebo effect with nutritional supplementation studies. A substantive proportion of supplement effects may be due to placebo effects, with the relative proportion influenced by the magnitude of the overall ergogenic effect. Where feasible, intervention studies should use nonplacebo control-arm comparators to identify the proportion of the effect estimated to come from placebo effects and avoid underestimating the overall benefits that the physiological plus psychobiological aspects associated with an intervention provide in the real world.
- beta-alanine Supplementation To Improve Exercise Capacity And Performance: A Systematic Review And Meta-analysis(2017) DOLAN, Eimear; ELLIOTT-SALE, Kirsty; ARTIOLI, Guilherme G.; SWINTON, Paul A.; ROSCHEL, Hamilton; SALE, Craig; GUALANO, Bruno; SAUNDERS, Bryan
- Twenty-four Weeks Of Beta-alanine Supplementation Increases Muscle Carnosine Content Despite Downregulation Of Beta-alanine Transporter Expression(2017) SAUNDERS, Bryan; PAINELLI, Vitor de Salles; OLIVEIRA, Luana Farias de; SILVA, Vinicius da Eira; SILVA, Rafael Pires da; RIANI, Luiz; FRANCHI, Mariana; GONCALVES, Livia de Souza; HARRIS, Roger Charles; ROSCHEL, Hamilton; ARTIOLI, Guilherme Giannini; SALE, Craig; GUALANO, Bruno
conferenceObject Individual Data Meta-analysis Provides No Evidence Of Individual Response Variation For Individuals Supplementing With Beta-alanine(2021) ESTEVES, Gabriel Perri; SWINTON, Paul; SALE, Craig; JAMES, Ruth; ARTIOLI, Guilherme Giannini; ROSCHEL, Hamilton; GUALANO, Bruno; SAUNDERS, Bryan; DOLAN, Eimear- Is Individualization of Sodium Bicarbonate Ingestion Based on Time to Peak Necessary?(2020) OLIVEIRA, Luana Farias De; SAUNDERS, Bryan; YAMAGUCHI, Guilherme; SWINTON, Paul; ARTIOLI, Guilherme GianniniPurpose To describe the reliability of blood bicarbonate pharmacokinetics in response to sodium bicarbonate (SB) supplementation across multiple occasions and assess, using putative thresholds, whether individual variation indicated a need for individualized ingestion timings. Methods Thirteen men (age 27 +/- 5 yr; body mass [BM], 77.4 +/- 10.5 kg; height, 1.75 +/- 0.06 m) ingested 0.3 g center dot kg(-1)BM SB in gelatine capsules on three occasions. One hour after a standardized meal, venous blood was obtained before and every 10 min after ingestion for 3 h, then every 20 min for a further hour. Time to peak (T-max), absolute peak (C-max), absolute peak change ( increment C-max), and area under the curve were analyzed using mixed models, intraclass correlation coefficient, coefficient of variation and typical error. Individual variation in pharmacokinetic responses was assessed using Bayesian simulation with multilevel models with random intercepts. Results No significant differences between sessions were shown for blood bicarbonate regardingC(max), increment C(max)or area under the curve (P> 0.05), althoughT(max)occurred earlier in SB2 (127 +/- 36 min) than in SB1 (169 +/- 54 min,P= 0.0088) and SB3 (159 +/- 42 min,P= 0.05). Intraclass correlation coefficient, coefficient of variation, and typical error showed moderate to poor reliability. Bayesian modeling estimated that >80% of individuals from the population experience elevated blood bicarbonate levels above +5 mmol center dot L(-1)between 75 and 240 min after ingestion, and between 90 and 225 min above +6 mmol center dot L-1. Conclusions Assessing SB supplementation using discrete values showed only moderate reliability at the group level, and poor reliability at the individual level, whereasT(max)was not reproducible. However, when analyzed as modeled curves, a 0.3-g center dot kg(-1)BM dose was shown to create a long-lasting window of ergogenic potential, challenging the notion that SB ingestion individualized to time-to-peak is a necessary strategy, at least when SB is ingested in capsules.