MAYARA LONGUI CABRINI
Projetos de Pesquisa
Unidades Organizacionais
LIM/63, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Obstructive sleep apnea and hypertension-mediated organ damage in nonresistant and resistant hypertension(2023) CABRINI, Mayara L.; MACEDO, Thiago A.; CASTRO, Emerson; BARROS, Silvana de; AZAM, Indira; PIO-ABREU, Andrea; SILVA, Giovanio V.; LORENZI-FILHO, Geraldo; BORTOLOTTO, Luiz A.; DRAGER, Luciano F.The potential role of obstructive sleep apnea (OSA) in hypertension-mediated organ damage (HMOD) may be influenced by the presence of resistant hypertension (RH). Herein, we enrolled patients with hypertension from a tertiary center for clinical evaluation and performed a sleep study to identify OSA (apnea-hypopnea index >= 15 events/h) and a blinded analysis of four standard HMOD parameters (left ventricular hypertrophy [LVH], increased arterial stiffness [>= 10 m/s], presence of retinopathy, and nephropathy). RH was diagnosed based on uncontrolled blood pressure (BP) (>= 140/90 mmHg) despite concurrent use of at least three antihypertensive drug classes or controlled BP with concurrent use of >= 4 antihypertensive drug classes at optimal doses. To avoid the white-coat effect, ambulatory BP monitoring was performed to confirm RH diagnosis. One-hundred patients were included in the analysis (mean age: 54 +/- 8 years, 65% females, body mass index: 30.4 +/- 4.5 kg/m(2)). OSA was detected in 52% of patients. Among patients with non-RH (n = 53), the presence of OSA (52.8%) was not associated with an increased frequency of HMOD. Conversely, among patients with RH, OSA (51.1%) was associated with a higher incidence of LVH (RH-OSA,61%; RH + OSA,87%; p = 0.049). Logistic regression analysis using the total sample revealed that RH (OR:7.89; 95% CI:2.18-28.52; p = 0.002), systolic BP (OR:1.04; 95% CI:1.00-1.07; p = 0.042) and OSA (OR:4.31; 95% CI:1.14-16.34; p = 0.032) were independently associated with LVH. No significant association was observed between OSA and arterial stiffness, retinopathy, or nephropathy. In conclusion, OSA is independently associated with LVH in RH, suggesting a potential role of OSA in RH prognosis.
conferenceObject Obstructive sleep apnea is associated with higher left ventricle hypertrophy frequency in patients with resistant hypertension(2020) CABRINI, Mayara Longui; MACEDO, Thiago A.; DEBARROS, Silvana; AZAM, Indira F. B.; PIO-ABREU, Andrea; SILVA, Giovanio V.; BORTOLOTTO, Luiz A.; LUCIANO, Luciano F.conferenceObject OBSTRUCTIVE SLEEP APNEA IS ASSOCIATED WITH HIGHER LEFT VENTRICLE HYPERTROPHY FREQUENCY IN PATIENTS WITH RESISTANT HYPERTENSION(2019) CABRINI, M. L.; MACEDO, T. A.; BARROS, S. de; AZAM, I. F. B.; PIO-ABREU, A.; SILVA, G. V.; LORENZI-FILHO, G.; BORTOLOTTO, L. A.; DRAGER, L. F.