MAGALI TAINO SCHMIDT
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- Index of alpha/theta ratio of the electroencephalogram: a new marker for Alzheimer's disease(2013) SCHMIDT, Magali T.; KANDA, Paulo A. M.; BASILE, Luis F. H.; LOPES, Helder Frederico da Silva; BARATHO, Regina; DEMARIO, Jose L. C.; JORGE, Mario S.; NARDI, Antonio E.; MACHADO, Sergio; IANOF, Jessica N.; NITRINI, Ricardo; ANGHINAH, RenatoObjective: We evaluated quantitative EEG measures to determine a screening index to discriminate Alzheimers disease (AD) patients from normal individuals. Methods: Two groups of individuals older than 50 years, comprising a control group of 57 normal volunteers and a study group of 50 patients with probable AD, were compared. EEG recordings were obtained from subjects in a wake state with eyes closed at rest for 30 min. Logistic regression analysis was conducted. Results: Spectral potentials of the alpha and theta bands were computed for all electrodes and the alpha/theta ratio calculated. Logistic regression of alpha/theta of the mean potential of the C3 and O1 electrodes was carried out. A formula was calculated to aid the diagnosis of AD yielding 76.4% sensitivity and 84.6% specificity for AD with an area under the ROC curve of 0.92. Conclusion: Logistic regression of alpha/theta of the spectrum of the mean potential of EEG represents a good marker discriminating AD patients from normal controls.
- BPSD following traumatic brain injury(2013) ANGHINAH, Renato; FREIRE, Fabio Rios; COELHO, Fernanda; LACERDA, Juliana Rhein; SCHMIDT, Magali Taino; CALADO, Vanessa Tomé Gonçalves; IANOF, Jéssica Natuline; MACHADO, Sergio; VELASQUES, Bruna; RIBEIRO, Pedro; BASILE, Luis Fernando Hindi; PAIVA, Wellingson Silva; AMORIM, Robson LuisABSTRACT Annually, 700,000 people are hospitalized with brain injury acquired after traumatic brain injury (TBI) in Brazil. Objective: We aim to review the basic concepts related to TBI, and the most common Behavioral and Psychological Symptoms of Dementia (BPSD) findings in moderate and severe TBI survivors. We also discussed our strategies used to manage such patients in the post-acute period. Methods: Fifteen TBI outpatients followed at the Center for Cognitive Rehabilitation Post-TBI of the Clinicas Hospital of the University of São Paulo were submitted to a neurological, neuropsychological, speech and occupational therapy evaluation, including the Mini-Mental State Examination. Rehabilitation strategies will then be developed, together with the interdisciplinary team, for each patient individually. Where necessary, the pharmacological approach will be adopted. Results: Our study will discuss options of pharmacologic treatment choices for cognitive, behavioral, or affective disorders following TBI, providing relevant information related to a structured cognitive rehabilitation service and certainly will offer an alternative for patients and families afflicted by TBI. Conclusion: Traumatic brain injury can cause a variety of potentially disabling psychiatric symptoms and syndromes. Combined behavioral and pharmacological strategies, in the treatment of a set of highly challenging behavioral problems, appears to be essential for good patient recovery.
- Sport-related concussions(2014) IANOF, Jéssica Natuline; FREIRE, Fabio Rios; CALADO, Vanessa Tomé Gonçalves; LACERDA, Juliana Rhein; COELHO, Fernanda; VEITZMAN, Silvia; SCHMIDT, Magali Taino; MACHADO, Sergio; VELASQUES, Bruna; RIBEIRO, Pedro; BASILE, Luis Fernando Hindi; PAIVA, Wellingson Silva; AMORIM, Robson; ANGHINAH, RenatoABSTRACT Traumatic brain injury (TBI) is a major cause of lifelong disability and death worldwide. Sport-related traumatic brain injury is an important public health concern. The purpose of this review was to highlight the importance of sport-related concussions. Concussion refers to a transient alteration in consciousness induced by external biomechanical forces transmitted directly or indirectly to the brain. It is a common, although most likely underreported, condition. Contact sports such as American football, rugby, soccer, boxing, basketball and hockey are associated with a relatively high prevalence of concussion. Various factors may be associated with a greater risk of sport-related concussion, such as age, sex, sport played, level of sport played and equipment used. Physical complaints (headache, fatigue, dizziness), behavioral changes (depression, anxiety, irritability) and cognitive impairment are very common after a concussion. The risk of premature return to activities includes the prolongation of post-concussive symptoms and increased risk of concussion recurrence.