ANDREA SCHMITT
Projetos de Pesquisa
Unidades Organizacionais
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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- Failed regeneration and inflammation in schizophrenia: two sides of the same coin?(2022) FALKAI, Peter; SCHMITT, AndreaMore than 100 years after its conceptual definition as 'Dementia Praecox' by Emil Kraepelin, which was changed to schizophrenia by Eugen Bleuler, this is still a serious and debilitating psychiatric illness. The neurodevelopmental hypothesis of schizophrenia, introduced more than 30 years ago, states that schizophrenia is a consequence of failed neurodevelopmental processes leading to a dysfunctional neuronal network forming the basis for a psychosis proneness. Subsequently, significant research efforts were made to prove the neurodevelopmental or the neurodegenerative perspective. This review summarizes key arguments speaking for or against the two hypotheses leading to a concept with both aspects position side by side.
- Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health(2022) FALKAI, Peter; KOUTSOULERIS, Nikolaos; BERTSCH, Katja; BIALAS, Mirko; BINDER, Elisabeth; BUEHNER, Markus; BUYX, Alena; CAI, Na; CAPPELLO, Silvia; EHRING, Thomas; GENSICHEN, Jochen; HAMANN, Johannes; HASAN, Alkomiet; HENNINGSEN, Peter; LEUCHT, Stefan; MOEHRMANN, Karl Heinz; NAGELSTUTZ, Elisabeth; PADBERG, Frank; PETERS, Annette; PFAEFFEL, Lea; REICH-ERKELENZ, Daniela; RIEDL, Valentin; RUECKERT, Daniel; SCHMITT, Andrea; SCHULTE-KOERNE, Gerd; SCHEURING, Elfriede; SCHULZE, Thomas G.; STARZENGRUBER, Rudolf; STIER, Susanne; THEIS, Fabian J.; WINKELMANN, Juliane; WURST, Wolfgang; PRILLER, JosefThe Federal Ministry of Education and Research (BMBF) issued a call for a new nationwide research network on mental disorders, the German Center of Mental Health (DZPG). The Munich/Augsburg consortium was selected to participate as one of six partner sites with its concept ""Precision in Mental Health (PriMe): Understanding, predicting, and preventing chronicity."" PriMe bundles interdisciplinary research from the Ludwig-Maximilians-University (LMU), Technical University of Munich (TUM), University of Augsburg (UniA), Helmholtz Center Munich (HMGU), and Max Planck Institute of Psychiatry (MPIP) and has a focus on schizophrenia (SZ), bipolar disorder (BPD), and major depressive disorder (MDD). PriMe takes a longitudinal perspective on these three disorders from the at-risk stage to the first-episode, relapsing, and chronic stages. These disorders pose a major health burden because in up to 50% of patients they cause untreatable residual symptoms, which lead to early social and vocational disability, comorbidities, and excess mortality. PriMe aims at reducing mortality on different levels, e.g., reducing death by psychiatric and somatic comorbidities, and will approach this goal by addressing interdisciplinary and cross-sector approaches across the lifespan. PriMe aims to add a precision medicine framework to the DZPG that will propel deeper understanding, more accurate prediction, and personalized prevention to prevent disease chronicity and mortality across mental illnesses. This framework is structured along the translational chain and will be used by PriMe to innovate the preventive and therapeutic management of SZ, BPD, and MDD from rural to urban areas and from patients in early disease stages to patients with long-term disease courses. Research will build on platforms that include one on model systems, one on the identification and validation of predictive markers, one on the development of novel multimodal treatments, one on the regulation and strengthening of the uptake and dissemination of personalized treatments, and finally one on testing of the clinical effectiveness, utility, and scalability of such personalized treatments. In accordance with the translational chain, PriMe's expertise includes the ability to integrate understanding of bio-behavioral processes based on innovative models, to translate this knowledge into clinical practice and to promote user participation in mental health research and care.
- Aerobic exercise in severe mental illness: requirements from the perspective of sports medicine(2022) FALKAI, Peter; SCHMITT, Andrea; ROSENBEIGER, Christian P.; MAURUS, Isabel; HATTENKOFER, Lisa; HASAN, Alkomiet; MALCHOW, Berend; HEIM-OHMAYER, Pascale; HALLE, Martin; HEITKAMP, MelanieMajor depression, bipolar disorder, and schizophrenia are severe mental illnesses. Despite receiving psychopharmacological and psychosocial treatments, about half of patients develop a chronic course with residual cognitive and negative symptoms and have a high risk for cardiovascular disease and reduced life expectancy. Therefore, add-on innovative treatment approaches are needed to improve outcome. Aerobic exercise interventions have been shown to improve global functioning, cognition, and negative and depressive symptoms in these patients. The basic mechanism of these exercise-related changes has been reported to be improved brain plasticity, e.g., increased volume of disease-related brain regions such as the hippocampus. The optimal type, duration, and frequency of exercise have not yet been determined and need to be addressed in supervised physical exercise studies. Because of the low physical activity levels, lack of drive related to negative and depressive symptoms, and high prevalence of cardiovascular comorbidities in patients with severe mental illness, besides aiming to improve symptoms of mental illness, exercise interventions should also aim to increase cardiorespiratory fitness, which they should comprehensively assess by direct measurements of maximal oxygen uptake. Based on the recommendations for developing cardiorespiratory fitness by the American College of Sports Medicine, 150 min moderate-intensity training per week or vigorous-intensity exercise training for 75 min per week are appropriate. Most studies have had relatively short intervention periods, so future studies should focus on long-term adherence to exercise by implementing motivational strategies supported by telemedicine and by identifying and targeting typical barriers to exercise in this patient population.