JOSE RODRIGUES PARGA FILHO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/65, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina
6 resultados
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conferenceObject A decrease in glycolytic metabolism in noncompaction cardiomyopathy - Insights into pathophysiological mechanisms(2016) MELO, M. Dantas Tavares De; GIORGI, M. Clementina; DANTAS JUNIOR, R. Nery; LIMA, C. Rocon De; PARGA FILHO, J. Roberto; SOARES JUNIOR, J.; MENEGHETTI, J. Claudio; BIERRENBACH, A. Luiza; BOCCHI, E. Alcides; SALEMI, V. M. C.conferenceObject BIOMARKERS AND CMR WITH LATE GADOLINIUM ENHANCEMENT FOR DIAGNOSIS OF PROCEDURE-RELATED MYOCARDIAL NECROSIS: A PROSPECTIVE TRIAL USING THE THIRD UNIVERSAL DEFINITION OF MYOCARDIAL INFARCTION(2013) HUEB, Whady; NOMURA, Cesar; VILLA, Alexandre V.; PARGA, Jose; COSTA, Leandro; MELO, Rodrigo M. V.; OIKAWA, Fernando T. C.; STRUNZ, Celia; REZENDE, Paulo; LIMA, Eduardo; GARZILLO, Cibele L.; RIBEIRO, Expedito E.; HUEB, Alexandre; SERRANO, Carlos; RAMIRES, Jose; KALIL-FILHO, RobertoBackground: The elevation of cardiac biomarkers after percutaneous or surgical myocardial revascularization procedures is common. However, the correlation between the release and the diagnosis of procedure-related myocardial infarction (Ml) remains unknown. In this study we aim to compare the release of cardiac biomarkers after mechanical interventions with the presence of late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR). Methods: In this prospective study, we evaluated 64 stable multivessel coronary artery disease patients with preserved ventricular function and formal indication to revascularization. The release of troponin and CKMB for diagnosis of procedure-related Ml was defined as the third universal definition of Ml. CMR with LGE was performed in all patients before and after interventions. Measurements of cardiac biomarkers were performed before and after the procedure, every 6 hours until 48h after PCI and 72h after CABG. Results: Of 64 patients, 44 (68.8%) underwent CABG and 20 (31.2%) underwent PCI; 46 (72%) were male, 45 (70%) had 3-vessel disease, 33 (52%) had diabetes and 23 (36%) had class Ill/IV of angina. For CABG patients, injury occurred in 95.5% (troponin) and 25% (CKMB); for PCI patients injury occurred in 70% (troponin) and 5% (CKMB). From the initial 64 patients, 14 (21.9%) had new LGE on post-procedure CMR, 13 after CABG and 1 after PCI. From these 14 patients, 7 (50%) presented elevation of CKMB above the cutoffs and troponin was elevated in all patients. From the 50 patients with no new LGE on CMR, 5 (10%) presented CKMB elevation and 42 (84%) presented troponin elevation above the 99th percentile. Based on current cutoffs, troponin had a sensitivity of 100% and specificity of 16% (positive predictive value of 25% and negative predictive value of 100%). CKMB had a sensitivity of 50% and specificity of 90% (positive predictive value of 58% and negative predictive value of 87%). Conclusion: In this study, cardiac biomarkers had a low accuracy for the diagnosis of procedure-related myocardial infarction based on LGE CMR.conferenceObject Computed Tomography Evaluation of Adamkiewicz Artery in Patients With and Without Aortic Disease(2016) AMATO, Alexandre C. M.; PARGA FILHO, Jose R.; STOLF, Noedir A. G.conferenceObject Clinical, electrocardiographic, echocardiographic and cardiac magnetic resonance imaging follow-up in patients with non-compaction cardiomyopathy in isolation or in association with other diseases(2018) ROCON, C.; MELO, M. D. Tavares De; ARAUJO FILHO, J. A.; PARGA FILHO, J. R.; HAJJAR, L. A.; KALIL FILHO, R.; BOCCHI, E. A.; SALEMI, V. M.conferenceObject Biventricular imaging markers to predict outcome in non-compaction cardiomyopathy: a machine learning study(2018) ROCON, C.; TABASSIAN, M.; MELO, M. D. Tavares De; ARAUJO FILHO, J. A.; PARGA FILHO, J. R.; HAJJAR, L. A.; KALIL FILHO, R.; BOCCHI, E. A.; D'HOOGE, J.; SALEMI, V. M. C.conferenceObject HIGH SENSITIVITY CARDIAC TROPONIN I CHANGES RELATED WITH T1 MAPPING IN PATIENTS WITH CHRONIC ISCHAEMIC HEART DISEASE WITHOUT LATE ENHANCEMENT GADOLINIUM BY CRM(2015) SEGRE, Carlos; ASSUNCAO JUNIOR, Antonildes Nascimento; NOMURA, Cesar; VILLA, Alexandre; STRUNZ, Celia; REZENDE, Paulo; PARGA, Jose; TAKIUTI, Myrthes Emy; HUEB, Whady; RAMIRES, Jose; KALIL-FILHO, Roberto