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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/65, Hospital das Clínicas, Faculdade de Medicina

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  • article 2 Citação(ões) na Scopus
    Clinical evaluation of left ventricular function and morphology using an accelerated k-t sensitivity encoding method in cardiovascular magnetic resonance
    (2019) ASSUNCAO- JR., Antonildes Nascimento; DANTAS- JR., Roberto Nery; VAL, Renata Margarida do; GIANOTTO, Priscilla; MARIN, Angela dos Santos; GOLDEN, Mark; GUTIERREZ, Marco Antonio; PARGA, Jose Rodrigues; NOMURA, Cesar Higa
    ObjectivesTo provide clinical validation of a recent 2D SENSE-based accelerated cardiovascular magnetic resonance (CMR) sequence (accelerated k-t SENSE), investigating whether this technique accurately quantifies left ventricle (LV) volumes, function, and mass as compared to 2D cine steady-state free precession (2D-SSFP).MethodsHealthy volunteers (n=16) and consecutive heart failure patients (n=26) were scanned using a 1.5T MRI system. Two LV short axis (SA) stacks were acquired: (1) accelerated k-t SENSE (5-6 breath-holds; temporal/spatial resolution: 37ms/1.82x1.87mm; acceleration factor = 4) and (2) standard 2D-SSFP (10-12 breath-holds; temporal/spatial resolution: 49ms/1.67x1.87mm, parallel imaging). Ascending aorta phase-contrast was performed on all volunteers as a reference to compare LV stroke volumes (LVSV) and validate the sequences. An image quality score for SA images was used, with lower scores indicating better quality (from 0 to 18).ResultsThere was a high agreement between accelerated k-t SENSE and 2D-SSFP for LV measurements: bias (limits of agreement) of 2.4% (-5.4% to 10.1%), 6.9mL/m(2) (-4.7 to 18.6mL/m(2)), -1.5 (-8.3 to 5.2mL/m(2)), and -0.2g/m(2) (-11.9 to 12.3g/m(2)) for LV ejection fraction, end-diastolic volume index, end-systolic volume index, and mass index, respectively. LVSV by accelerated k-t SENSE presented good agreement with aortic flow. Interobserver and intraobserver variabilities for all LV parameters were also high.ConclusionThe accelerated k-t SENSE CMR sequence is clinically feasible and accurately quantifies LV volumes, function, and mass, with short acquisition time and good image quality.