JOAO RICARDO SATO

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LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: EURIPEDES CONSTANTINO MIGUEL FILHO ×

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Agora exibindo 1 - 10 de 23
  • article 10 Citação(ões) na Scopus
    Commentary: Functional connectome fingerprint: identifying individuals using patterns of brain connectivity
    (2017) BIAZOLI JR., Claudinei E.; SALUM, Giovanni A.; PAN, Pedro M.; ZUGMAN, Andre; AMARO JR., Edson; ROHDE, Luis A.; MIGUEL, Euripedes C.; JACKOWSKI, Andrea P.; BRESSAN, Rodrigo A.; SATO, Joao R.
  • article 16 Citação(ões) na Scopus
    An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder
    (2016) LIMA, Leandro de Araujo; FEIO-DOS-SANTOS, Ana Cecilia; BELANGERO, Sintia Iole; GADELHA, Ary; BRESSAN, Rodrigo Affonseca; SALUM, Giovanni Abrahao; PAN, Pedro Mario; MORIYAMA, Tais Silveira; GRAEFF-MARTINS, Ana Soledade; TAMANAHA, Ana Carina; ALVARENGA, Pedro; KRIEGER, Fernanda Valle; FLEITLICH-BILYK, Bacy; JACKOWSKI, Andrea Parolin; BRIETZKE, Elisa; SATO, Joao Ricardo; POLANCZYK, Guilherme Vanoni; MARI, Jair de Jesus; MANFRO, Gisele Gus; ROSARIO, Maria Conceicao do; MIGUEL, Euripedes Constantino; PUGA, Renato David; TAHIRA, Ana Carolina; SOUZA, Viviane Neri; CHILE, Thais; GOUVEIA, Gisele Rodrigues; SIMOES, Sergio Nery; CHANG, Xiao; PELLEGRINO, Renata; TIAN, Lifeng; GLESSNER, Joseph T.; HASHIMOTO, Ronaldo Fumio; ROHDE, Luis Augusto; SLEIMAN, Patrick M. A.; HAKONARSON, Hakon; BRENTANI, Helena
    Many studies have attempted to investigate the genetic susceptibility of Attention-Deficit/Hyperactivity Disorder (ADHD), but without much success. The present study aimed to analyze both single-nucleotide and copy-number variants contributing to the genetic architecture of ADHD. We generated exome data from 30 Brazilian trios with sporadic ADHD. We also analyzed a Brazilian sample of 503 children/adolescent controls from a High Risk Cohort Study for the Development of Childhood Psychiatric Disorders, and also previously published results of five CNV studies and one GWAS meta-analysis of ADHD involving children/adolescents. The results from the Brazilian trios showed that cases with de novo SNVs tend not to have de novo CNVs and vice-versa. Although the sample size is small, we could also see that various comorbidities are more frequent in cases with only inherited variants. Moreover, using only genes expressed in brain, we constructed two ""in silico"" protein-protein interaction networks, one with genes from any analysis, and other with genes with hits in two analyses. Topological and functional analyses of genes in this network uncovered genes related to synapse, cell adhesion, glutamatergic and serotoninergic pathways, both confirming findings of previous studies and capturing new genes and genetic variants in these pathways.
  • conferenceObject
    Treatment Response Prediction in Pediatric Patients With OCD Using Structural Neuroimaging Correlates: Simple Linear Regression Versus Support Vector Regression
    (2017) VATTIMO, Edoardo; BARROS, Vivian; BATISTUZZO, Marcelo; REQUENA, Guaraci; SATO, Joao; FATORI, Daniel; SHAVITT, Roseli; MIGUEL, Euripedes; HOEXTER, Marcelo
  • article
    Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta-and Mega-Analysis (vol , pg , 2016)
    (2017) ABE, Yoshinari; ALONSO, Pino; AMEIS, Stephanie H.; ARNOLD, Paul D.; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan C.; BOEDHOE, Premika S. W.; BOLLETTINI, Irene; BOSE, Anushree; BREM, Silvia; BUSATTO, Geraldo F.; CALVO, Anna; CALVO, Rosa; CATH, Danielle C.; CHENG, Yuqi; CHO, Kang Ik K.; DALLASPEZIA, Sara; VRIES, Froukje E. de; WIT, Stella J. de; DENYS, Damiaan; FANG, Yu; FITZGERALD, Kate D.; FONTAINE, Martine; FOUCHE, Jean-Paul; GIMENEZ, Monica; GRUNER, Patricia; HANNA, Gregory L.; HIBAR, Derrek P.; HOEXTER, Marcelo Q.; HU, Hao; HUYSER, Chaim; IKARI, Keisuke; JAHANSHAD, Neda; KATHMANN, Norbert; KAUFMANN, Christian; KHADKA, Sabin; KOCH, Kathrin; KWON, Jun Soo; LAZARO, Luisa; LIU, Yanni; LOCHNER, Christine; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MATAIX-COLS, David; MENCHON, Jose M.; MIGUEL, Euripedes C.; MINUZZI, Luciano; MORER, Astrid; NAKAMAE, Takashi; NAKAO, Tomohiro; NARAYANASWAMY, Janardhanan C.; PIRAS, Fabrizio; PIRAS, Federica; PITTENGER, Christopher; REDDY, Y. C. Janardhan; SATO, Joao R.; SIMPSON, H. Blair; SCHMAAL, Lianne; SORENI, Noam; SORIANO-MAS, Carles; SPALLETTA, Gianfranco; STEIN, Dan J.; STEVENS, Michael C.; SZESZKO, Philip R.; THOMPSON, Paul M.; TOLIN, David F.; VELTMAN, Dick J.; VENKATASUBRAMANIAN, Ganesan; HEUVEL, Odile A. van den; WERF, Ysbrand D. van der; WINGEN, Guido A. van; WALITZA, Susanne; WANG, Zhen; XU, Jian; XU, Xiufeng; YUN, Je-Yeon; ZHAO, Qing
  • article 8 Citação(ões) na Scopus
    Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems
    (2019) SATO, Joao Ricardo; JR, Claudinei Eduardo Biazoli; SALUM, Giovanni Abrahao; GADELHA, Ary; CROSSLEY, Nicolas; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; JR, Edson Amaro; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; MCGUIRE, Philip; ROHDEZ, Luis Augusto; MIGUEL, Euripedes Constantino; BRESSAN, Rodrigo Affonseca; JACKOWSKI, Andrea Parolin
    The family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous oscillatory neural activity, the fractional amplitude of low-frequency fluctuations (fALFF), is associated with the levels of children's family coherence and conflict. Moreover, we sought to further explore whether spontaneous activity in the brain areas influenced by family environment would also be associated with a mental health outcome, namely the incidence of behavioral and emotional problems. Resting-state fMRI data from 655 children and adolescents (6-15years old) were examined. The quality of the family environment was found to be positively correlated with fALFF in the left temporal pole and negatively correlated with fALFF in the right orbitofrontal cortex. Remarkably, increased fALFF in the temporal pole was associated with a lower incidence of behavioral and emotional problems, whereas increased fALFF in the orbitofrontal cortex was correlated with a higher incidence.
  • article 95 Citação(ões) na Scopus
    Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
    (2017) PAN, Pedro Mario; SATO, Joao R.; SALUM, Giovanni A.; ROHDE, Luis A.; GADELHA, Ary; ZUGMAN, Andre; MARI, Jair; JACKOWSKI, Andrea; PICON, Felipe; MIGUEL, Euripedes C.; PINE, Daniel S.; LEIBENLUFT, Ellen; BRESSAN, Rodrigo A.; STRINGARIS, Argyris
    Objective: Previous studies have implicated aberrant reward processing in the pathogenesis of adolescent depression. However, no study has used functional connectivity within a distributed reward network, assessed using resting-state functional MRI (fMRI), to predict the onset of depression in adolescents. This study used reward network-based functional connectivity at baseline to predict depressive disorder at follow-up in a community sample of adolescents. Method: A total of 637 children 6-12 years old underwent resting-state fMRI. Discovery and replication analyses tested intrinsic functional connectivity (iFC) among nodes of a putative reward network. Logistic regression tested whether striatal node strength, a measure of reward-related iFC, predicted onset of a depressive disorder at 3-year follow-up. Further analyses investigated the specificity of this prediction. Results: Increased left ventral striatum node strength predicted increased risk for future depressive disorder (odds ratio=1.54, 95% CI=1.09-2.18), even after excluding participants who had depressive disorders at baseline (odds ratio=1.52, 95% CI=1.05-2.20). Among 11 reward-network nodes, only the left ventral striatum significantly predicted depression. Striatal node strength did not predict other common adolescent psychopathology, such as anxiety, attention deficit hyperactivity disorder, and substance use. Conclusions: Aberrant ventral striatum functional connectivity specifically predicts future risk for depressive disorder. This finding further emphasizes the need to understand how brain reward networks contribute to youth depression.
  • article 217 Citação(ões) na Scopus
    Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
    (2014) WIT, Stella J. de; ALONSO, Pino; SCHWEREN, Lizanne; MATAIX-COLS, David; LOCHNER, Christine; MENCHON, Jose M.; STEIN, Dan J.; FOUCHE, Jean-Paul; SORIANO-MAS, Caries; SATO, Joao R.; HOEXTER, Marcelo Q.; DENYS, Damiaan; NAKAMAE, Takashi; NISHIDA, Seiji; KWON, Jun Soo; JANG, Joon Hwan; BUSATTO, Geraldo F.; CARDONER, Narcis; CATH, Danielle C.; FUKUI, Kenji; JUNG, Wi Hoon; KIM, Sung Nyun; MIGUEL, Euripides C.; NARUMOTO, Jin; PHILLIPS, Mary L.; PUJOL, Jesus; REMIJNSE, Peter L.; SAKAI, Yuki; SHIN, Na Young; YAMADA, Kei; VELTMAN, Dick J.; HEUVEL, Odile A. van den
    Objective: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables. Method: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T str.uctural T-1-weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects. Results: Relative to healthy comparison subjects, OCD patients had significantly smaller volumes of frontal gray and white matter bilaterally, including the dorsomedial prefrontal cortex, the anterior cingulate cortex, and the inferior frontal gyrus extending to the anterior insula. Patients also showed greater cerebellar gray matter volume bilaterally compared with healthy subjects. Group differences in frontal gray and white matter volume were significant after correction for multiple comparisons. Additionally, group-by-age interactions were observed in the putamen, insula, and orbitofrontal cortex (indicating relative preservation of volume in patients compared with healthy subjects with increasing age) and in the temporal cortex bilaterally (indicating a relative loss of volume in patients compared. with healthy subjects with increasing age). Conclusions: These findings partially support the prevailing fronto-striatal models of OCD and offer additional insights into the neuroanatomy of the disorder that were not apparent from previous smaller studies. The group-by-age interaction effects. in orbitofrontal-striatal and (para)limbic brain regions may be the result of altered neuroplasticity associated with chronic compulsive behaviors, anxiety, or compensatory processes related to cognitive dysfunction.
  • article 22 Citação(ões) na Scopus
    Temporal Stability of Network Centrality in Control and Default Mode Networks: Specific Associations with Externalizing Psychopathology in Children and Adolescents
    (2015) SATO, Joao Ricardo; BIAZOLI JR., Claudinei Eduardo; SALUM, Giovanni Abrahao; GADELHA, Ary; CROSSLEY, Nicolas; SATTERTHWAITE, Theodore D.; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; AMARO JR., Edson; MCGUIRE, Philip; LACERDA, Acioly L. T.; ROHDE, Luis Augusto; MIGUEL, Euripedes Constantino; JACKOWSKI, Andrea Parolin; BRESSAN, Rodrigo Affonseca
    Abnormal connectivity patterns have frequently been reported as involved in pathological mental states. However, most studies focus on ""static,"" stationary patterns of connectivity, which may miss crucial biological information. Recent methodological advances have allowed the investigation of dynamic functional connectivity patterns that describe non-stationary properties of brain networks. Here, we introduce a novel graphical measure of dynamic connectivity, called time-varying eigenvector centrality (tv-EVC). In a sample 655 children and adolescents (7-15 years old) from the Brazilian ""High Risk Cohort Study for Psychiatric Disorders"" who were imaged using resting-state fMRI, we used this measure to investigate age effects in the temporal in control and default-mode networks (CN/DMN). Using support vector regression, we propose a network maturation index based on the temporal stability of tv-EVC. Moreover, we investigated whether the network maturation is associated with the overall presence of behavioral and emotional problems with the Child Behavior Checklist. As hypothesized, we found that the tv-EVC at each node of CN/DMN become more stable with increasing age (P < 0.001 for all nodes). In addition, the maturity index for this particular network is indeed associated with general psychopathology in children assessed by the total score of Child Behavior Checklist (P = 0.027). Moreover, immaturity of the network was mainly correlated with externalizing behavior dimensions. Taken together, these results suggest that changes in functional network dynamics during neurodevelopment may provide unique insights regarding pathophysiology. (C) 2015 Wiley Periodicals, Inc.
  • article 5 Citação(ões) na Scopus
    Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus
    (2020) JR, Claudinei Eduardo Biazoli; SALUM, Giovanni Abrahao; GADELHA, Ary; REBELLO, Keila; MOURA, Luciana Monteiro; PAN, Pedro Mario; BRIETZKE, Elisa; MIGUEL, Euripedes Constantino; ROHDE, Luis Augusto; BRESSAN, Rodrigo Affonseca; JACKOWSKI, Andrea Parolin; SATO, Joao Ricardo
    Socioeconomic status (SES) during childhood is a well-documented life-course health determinant. Despite recent advances on characterizing brain structural variance associated with SES during development, how it influences brain's functional organization remains elusive. Associations between SES, an fMRI feature of regional spontaneous activity (fractional amplitude of low frequencies fluctuation, fALFF), and behavioral/emotional problems were investigated in a school-based sample of 655 Brazilian children. A voxel-by-voxel approach was applied in order to map brain regions where fALFF was correlated with SES. Based on compelling previous evidence, we hypothesized that fALFF should be associated with SES in areas involved in language processing or cognitive control. Further, we tested if the spontaneous activity in these mapped areas would also correlated with general, internalizing and externalizing problems. SES of children was found to be positively correlated with spontaneous activity in right superior temporal gyrus. In the exploratory analysis, the fALFF of this area was negatively correlated with the expression of internalizing problems. Extending previous behavioral and structural neuroimaging findings, we report an association between SES and the spontaneous activity of a brain area enrolled in the extended language network. This finding is consistent with the hypothesis that the variability on linguistic environment according to SES lead to different developmental trajectories of functional networks instantiating language.
  • article 24 Citação(ões) na Scopus
    White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group
    (2021) PIRAS, Fabrizio; PIRAS, Federica; ABE, Yoshinari; AGARWAL, Sri Mahavir; ANTICEVIC, Alan; AMEIS, Stephanie; ARNOLD, Paul; BANAJ, Nerisa; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan-Carl; BOEDHOE, Premika S. W.; BOLLETTINI, Irene; BREM, Silvia; CALVO, Anna; CHO, Kang Ik Kevin; CIULLO, Valentina; DALLASPEZIA, Sara; DICKIE, Erin; ELY, Benjamin Adam; FAN, Siyan; FOUCHE, Jean-Paul; GRUNER, Patricia; GUERSEL, Deniz A.; HAUSER, Tobias; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; IORIO, Mariangela; JAMES, Anthony; REDDY, Y. C. Janardhan; KAUFMANN, Christian; KOCH, Kathrin; KOCHUNOV, Peter; KWON, Jun Soo; LAZARO, Luisa; LOCHNER, Christine; MARSH, Rachel; NAKAGAWA, Akiko; NAKAMAE, Takashi; NARAYANASWAMY, Janardhanan C.; SAKAI, Yuki; SHIMIZU, Eiji; SIMON, Daniela; SIMPSON, Helen Blair; SORENI, Noam; STAEMPFLI, Philipp; STERN, Emily R.; SZESZKO, Philip; TAKAHASHI, Jumpei; VENKATASUBRAMANIAN, Ganesan; WANG, Zhen; YUN, Je-Yeon; STEIN, Dan J.; JAHANSHAD, Neda; THOMPSON, Paul M.; HEUVEL, Odile A. van den; SPALLETTA, Gianfranco; ASSOGNA, Francesca; CALVO, Rosa; WIT, Stella J. de; HOUGH, Morgan; KUNO, Masaru; MIGUEL, Euripedes C.; MORER, Astrid; PITTENGER, Christopher; POLETTI, Sara; SMERALDI, Enrico; SATO, Joao R.; TSUCHIYAGAITO, Aki; WALITZA, Susanne; WERF, Ysbrand D. van der; VECCHIO, Daniela; ZAREI, Mojtaba
    Microstructural alterations in cortico-subcortical connections are thought to be present in obsessive-compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities. Here we investigated microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date. We analyzed diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA OCD Working Group, in a cross-sectional case-control magnetic resonance study. We extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen's d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics. Adult OCD patients showed significant FA reduction in the sagittal stratum (d=-0.21, z=-3.21, p=0.001) and posterior thalamic radiation (d=-0.26, z=-4.57, p<0.0001). In the sagittal stratum, lower FA was associated with a younger age of onset (z=2.71, p=0.006), longer duration of illness (z=-2.086, p=0.036), and a higher percentage of medicated patients in the cohorts studied (z=-1.98, p=0.047). No significant association with symptom severity was found. Pediatric OCD patients did not show any detectable microstructural abnormalities compared to controls. Our findings of microstructural alterations in projection and association fibers to posterior brain regions in OCD are consistent with models emphasizing deficits in connectivity as an important feature of this disorder.