PEDRO MACUL FERREIRA DE BARROS

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LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: MARCELO QUEIROZ HOEXTER ×

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    CHARACTERISTICS OF TICS IN FOLLOW-UP STUDY OF COMMUNITY-BASED HIGH RISK COHORT OF 2511 CHILDREN
    (2023) SZEJKO, N.; BARROS, P. Macul Ferreira de; PANCZYK, M.; PAN, P. M.; ALVARENGA, P. Gomez de; HOEXTRA, M.; TIMPANO, K.; LECKMAN, J.; MIGUEL, E.
  • article 1 Citação(ões) na Scopus
    Obsessive-Compulsive Symptoms, Polygenic Risk Score, and Thalamic Development in Children From the Brazilian High-Risk Cohort for Mental Conditions (BHRCS)
    (2021) SALTO, Ana Beatriz Ravagnani; SANTORO, Marcos L.; HOEXTER, Marcelo Q.; JACKOWSKI, Andrea Parolin; PAN, Pedro M.; ROSARIO, Maria Conceicao; I, Sintia Belangero; ALVARENGA, Pedro Gomes; DORETTO, Victoria Fogaca; FUMO, Afonso Mazine Tiago; BATISTUZZO, Marcelo C.; BARROS, Pedro Macul Ferreira de; TIMPANO, Kiara R.; OTA, Vanessa K.; ROHDE, Luis Augusto; MIGUEL, Euripedes Constantino; LECKMAN, James F.; ZUGMAN, Andre
    Background: Thalamic volume measures have been linked to obsessive-compulsive disorder (OCD) in children and adolescents. However, it is unclear if alterations in thalamic volumes occur before or after symptom onset and if there is a relation to the presence of sub-clinical obsessive-compulsive symptoms (OCS). Here, we explore the relationship between OCS and the rate of thalamic volume change in a cohort of children and youth at high risk to develop a mental disorder. A secondary aim was to determine if there is a relationship between OCS and the individual's OCD polygenic risk score (OCD-PRS) and between the rate of thalamic volume change and the OCD-PRS. Methods: The sample included 378 children enrolled in the longitudinal Brazilian High-Risk Cohort for Mental Conditions. Participants were assessed for OCS and the symmetrized percent change (SPC) of thalamic volume across two time-points separated by 3 years, along with the OCD-PRS. Zero-altered negative binomial models were used to analyze the relationship between OCS and thalamic SPC. Multiple linear regressions were used to examine the relationship between thalamic SPC and OCD-PRS. Results: A significant relationship between OCS and the right thalamus SPC (p = 0.042) was found. There was no significant relationship between changes in thalamic volume SPC and OCD-PRS. Conclusions: The findings suggest that changes in the right thalamic volume over the course of 3 years in children may be associated to OCS. Future studies are needed to confirm these results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.
  • article 6 Citação(ões) na Scopus
    Risk factors for obsessive-compulsive symptoms. Follow-up of a community-based youth cohort
    (2021) BARROS, Pedro Macul Ferreira de; ROSARIO, Maria Conceicao do; SZEJKO, Natalia; POLGA, Natalia; REQUENA, Guaraci de Lima; RAVAGNANI, Beatriz; FATORI, Daniel; BATISTUZZO, Marcelo Camargo; HOEXTER, Marcelo Queiroz; ROHDE, Luis Augusto; POLANCZYK, Guilherme Vanoni; LECKMAN, James Frederick; MIGUEL, Euripedes Constantino; ALVARENGA, Pedro Gomes de
    Environmental factors are at least as important as genetic factors for the development of obsessive-compulsive symptoms (OCS), but the identification of such factors remain a research priority. Our study aimed to investigate the association between a broad scope of potential risk factors and OCS in a large community cohort of children and adolescents. We evaluated 1877 participants and their caregivers at baseline and after 3 years to assess various demographic, prenatal, perinatal, childhood adversity, and psychopathological factors. Mean age at baseline was 10.2 years (SD 1.9) and mean age at follow-up was 13.4 years (SD 1.9). Reports of OCS at baseline and follow-up were analyzed using latent variable models. At preliminary regression analysis, 15 parameters were significantly associated with higher OCS scores at follow-up. At subsequent regression analysis, we found that eight of these parameters remained significantly associated with higher follow-up OCS scores while being controlled by each other and by baseline OCS scores. The significant predictors of follow-up OCS were: lower socioeconomic status (p = 0.033); lower intelligence quotient (p = 0.013); lower age (p < 0.001); higher maternal stress level during pregnancy (p = 0.028); absence of breastfeeding (p = 0.017); parental baseline OCS (p = 0.038); youth baseline anxiety disorder (p = 0.023); and youth baseline OCS scores (p < 0.001). These findings may better inform clinicians and policymakers engaged in the mental health assessment and prevention in children and adolescents.