PEDRO MACUL FERREIRA DE BARROS
Projetos de Pesquisa
Unidades Organizacionais
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
conferenceObject Inhibitors of vesicular monoamine transporter type 2 (VMAT2) and the risk of anxiety and depression: meta-analysis(2022) SZEJKO, N.; CUENOD, M.; BARROS, P. Macul Ferreira de; ARTUKOGLU, B.; FLORES, J.; NASIR, M.; BLOCH, M.conferenceObject CHARACTERISTICS OF TICS IN FOLLOW-UP STUDY OF COMMUNITY-BASED HIGH RISK COHORT OF 2511 CHILDREN(2023) SZEJKO, N.; BARROS, P. Macul Ferreira de; PANCZYK, M.; PAN, P. M.; ALVARENGA, P. Gomez de; HOEXTRA, M.; TIMPANO, K.; LECKMAN, J.; MIGUEL, E.- Family accommodation mediates the impact of childhood anxiety on functional impairment(2020) BARROS, Pedro Macul Ferreira de; POLGA, Natalia; SZEJKO, Natalia; MIGUEL, Euripedes Constantino; LECKMAN, James Frederick; SILVERMAN, Wendy K.; LEBOWITZ, Eli R.Background: Anxiety disorders are the most common childhood-onset psychiatric disorders and are extensively associated with child functional impairment. Data suggest that family accommodation plays a role in the association between anxiety severity and functional impairment in children, but more empirical evidence is needed. Methods: Participants were 425 clinically anxious children (ages 6-17 years), and their mothers. We first examined associations between child anxiety symptom severity, family accommodation, and child functional impairment. Next, we investigated the hypothesized mediation pathway linking anxiety severity to child impairment through increased family accommodation using structural equation modeling. We tested two models: one using parent ratings of their child's anxiety and the other using the child's self-ratings. Finally, we estimated the effect sizes of the mediation pathway in both models. Results: Family accommodation was significantly correlated with all the study variables. Child functional impairment was significantly correlated with parent-rated and self-rated child anxiety severity. Both structural equation models provided excellent fit for the data and supported the theoretical model by which family accommodation significantly explains part of the association between anxiety symptoms and functional impairment. The indirect effect sizes indicate that family accommodation accounts for between a fifth and a half of the impairment associated with symptom severity. Conclusions: The data provide important empirical evidence that family accommodation mediates the association between child anxiety and functional impairment and accounts for up to 50 % of this association. These findings contribute to the growing understanding of the critical role of family accommodation and underscore the importance of assessing accommodation when evaluating and treating anxious children.
- Risk factors for obsessive-compulsive symptoms. Follow-up of a community-based youth cohort(2021) BARROS, Pedro Macul Ferreira de; ROSARIO, Maria Conceicao do; SZEJKO, Natalia; POLGA, Natalia; REQUENA, Guaraci de Lima; RAVAGNANI, Beatriz; FATORI, Daniel; BATISTUZZO, Marcelo Camargo; HOEXTER, Marcelo Queiroz; ROHDE, Luis Augusto; POLANCZYK, Guilherme Vanoni; LECKMAN, James Frederick; MIGUEL, Euripedes Constantino; ALVARENGA, Pedro Gomes deEnvironmental factors are at least as important as genetic factors for the development of obsessive-compulsive symptoms (OCS), but the identification of such factors remain a research priority. Our study aimed to investigate the association between a broad scope of potential risk factors and OCS in a large community cohort of children and adolescents. We evaluated 1877 participants and their caregivers at baseline and after 3 years to assess various demographic, prenatal, perinatal, childhood adversity, and psychopathological factors. Mean age at baseline was 10.2 years (SD 1.9) and mean age at follow-up was 13.4 years (SD 1.9). Reports of OCS at baseline and follow-up were analyzed using latent variable models. At preliminary regression analysis, 15 parameters were significantly associated with higher OCS scores at follow-up. At subsequent regression analysis, we found that eight of these parameters remained significantly associated with higher follow-up OCS scores while being controlled by each other and by baseline OCS scores. The significant predictors of follow-up OCS were: lower socioeconomic status (p = 0.033); lower intelligence quotient (p = 0.013); lower age (p < 0.001); higher maternal stress level during pregnancy (p = 0.028); absence of breastfeeding (p = 0.017); parental baseline OCS (p = 0.038); youth baseline anxiety disorder (p = 0.023); and youth baseline OCS scores (p < 0.001). These findings may better inform clinicians and policymakers engaged in the mental health assessment and prevention in children and adolescents.